Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine.

Hdl Handle:
http://hdl.handle.net/10147/336291
Title:
Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine.
Authors:
Judge, Eoin P; Hughes, J M Lynne; Egan, Jim J; Maguire, Michael; Molloy, Emer L; O'Dea, Shirley
Affiliation:
1 Irish National Lung and Heart Transplant Program, Mater Misericordiae University Hospital, Dublin, Ireland.
Citation:
Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine. 2014, 51 (3):334-43 Am. J. Respir. Cell Mol. Biol.
Journal:
American journal of respiratory cell and molecular biology
Issue Date:
Sep-2014
URI:
http://hdl.handle.net/10147/336291
DOI:
10.1165/rcmb.2013-0453TR
PubMed ID:
24828366
Abstract:
The porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model particularly beneficial for translational research in areas such as medical device development, therapeutics and xenotransplantation. In recent years, a major limitation with the porcine model was overcome with the successful generation of gene-targeted pigs and the publication of the pig genome. As a result, the role of this model is likely to become even more important. For the respiratory medicine field, the similarities between pig and human lungs give the porcine model particular potential for advancing translational medicine. An increasing number of lung conditions are being studied and modeled in the pig. Genetically modified porcine models of cystic fibrosis have been generated that, unlike mouse models, develop lung disease similar to human cystic fibrosis. However, the scientific literature relating specifically to porcine lung anatomy and airway histology is limited and is largely restricted to veterinary literature and textbooks. Furthermore, methods for in vivo lung procedures in the pig are rarely described. The aims of this review are to collate the disparate literature on porcine lung anatomy, histology, and microbiology; to provide a comparison with the human lung; and to describe appropriate bronchoscopy procedures for the pig lungs to aid clinical researchers working in the area of translational respiratory medicine using the porcine model.
Item Type:
Article
Language:
en
Keywords:
RESPIRATORY DISORDER
Local subject classification:
LUNG CONDITIONS; HISTOLOGY
MeSH:
Animals; Biomedical Research; Biopsy; Bronchi; Bronchoscopy; Cartilage; Disease Models, Animal; Genome; Humans; Inflammation; Lung; Respiration; Swine; Translational Medical Research; Transplantation, Heterologous
ISSN:
1535-4989

Full metadata record

DC FieldValue Language
dc.contributor.authorJudge, Eoin Pen_GB
dc.contributor.authorHughes, J M Lynneen_GB
dc.contributor.authorEgan, Jim Jen_GB
dc.contributor.authorMaguire, Michaelen_GB
dc.contributor.authorMolloy, Emer Len_GB
dc.contributor.authorO'Dea, Shirleyen_GB
dc.date.accessioned2014-11-27T16:36:46Z-
dc.date.available2014-11-27T16:36:46Z-
dc.date.issued2014-09-
dc.identifier.citationAnatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine. 2014, 51 (3):334-43 Am. J. Respir. Cell Mol. Biol.en_GB
dc.identifier.issn1535-4989-
dc.identifier.pmid24828366-
dc.identifier.doi10.1165/rcmb.2013-0453TR-
dc.identifier.urihttp://hdl.handle.net/10147/336291-
dc.description.abstractThe porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model particularly beneficial for translational research in areas such as medical device development, therapeutics and xenotransplantation. In recent years, a major limitation with the porcine model was overcome with the successful generation of gene-targeted pigs and the publication of the pig genome. As a result, the role of this model is likely to become even more important. For the respiratory medicine field, the similarities between pig and human lungs give the porcine model particular potential for advancing translational medicine. An increasing number of lung conditions are being studied and modeled in the pig. Genetically modified porcine models of cystic fibrosis have been generated that, unlike mouse models, develop lung disease similar to human cystic fibrosis. However, the scientific literature relating specifically to porcine lung anatomy and airway histology is limited and is largely restricted to veterinary literature and textbooks. Furthermore, methods for in vivo lung procedures in the pig are rarely described. The aims of this review are to collate the disparate literature on porcine lung anatomy, histology, and microbiology; to provide a comparison with the human lung; and to describe appropriate bronchoscopy procedures for the pig lungs to aid clinical researchers working in the area of translational respiratory medicine using the porcine model.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to American journal of respiratory cell and molecular biologyen_GB
dc.subjectRESPIRATORY DISORDERen_GB
dc.subject.meshAnimals-
dc.subject.meshBiomedical Research-
dc.subject.meshBiopsy-
dc.subject.meshBronchi-
dc.subject.meshBronchoscopy-
dc.subject.meshCartilage-
dc.subject.meshDisease Models, Animal-
dc.subject.meshGenome-
dc.subject.meshHumans-
dc.subject.meshInflammation-
dc.subject.meshLung-
dc.subject.meshRespiration-
dc.subject.meshSwine-
dc.subject.meshTranslational Medical Research-
dc.subject.meshTransplantation, Heterologous-
dc.subject.otherLUNG CONDITIONSen_GB
dc.subject.otherHISTOLOGYen_GB
dc.titleAnatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine.en_GB
dc.typeArticleen
dc.contributor.department1 Irish National Lung and Heart Transplant Program, Mater Misericordiae University Hospital, Dublin, Ireland.en_GB
dc.identifier.journalAmerican journal of respiratory cell and molecular biologyen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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