Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine.
Affiliation
1 Irish National Lung and Heart Transplant Program, Mater Misericordiae University Hospital, Dublin, Ireland.Issue Date
2014-09Keywords
RESPIRATORY DISORDERLocal subject classification
LUNG CONDITIONSHISTOLOGY
MeSH
AnimalsBiomedical Research
Biopsy
Bronchi
Bronchoscopy
Cartilage
Disease Models, Animal
Genome
Humans
Inflammation
Lung
Respiration
Swine
Translational Medical Research
Transplantation, Heterologous
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Anatomy and bronchoscopy of the porcine lung. A model for translational respiratory medicine. 2014, 51 (3):334-43 Am. J. Respir. Cell Mol. Biol.Journal
American journal of respiratory cell and molecular biologyDOI
10.1165/rcmb.2013-0453TRPubMed ID
24828366Abstract
The porcine model has contributed significantly to biomedical research over many decades. The similar size and anatomy of pig and human organs make this model particularly beneficial for translational research in areas such as medical device development, therapeutics and xenotransplantation. In recent years, a major limitation with the porcine model was overcome with the successful generation of gene-targeted pigs and the publication of the pig genome. As a result, the role of this model is likely to become even more important. For the respiratory medicine field, the similarities between pig and human lungs give the porcine model particular potential for advancing translational medicine. An increasing number of lung conditions are being studied and modeled in the pig. Genetically modified porcine models of cystic fibrosis have been generated that, unlike mouse models, develop lung disease similar to human cystic fibrosis. However, the scientific literature relating specifically to porcine lung anatomy and airway histology is limited and is largely restricted to veterinary literature and textbooks. Furthermore, methods for in vivo lung procedures in the pig are rarely described. The aims of this review are to collate the disparate literature on porcine lung anatomy, histology, and microbiology; to provide a comparison with the human lung; and to describe appropriate bronchoscopy procedures for the pig lungs to aid clinical researchers working in the area of translational respiratory medicine using the porcine model.Item Type
ArticleLanguage
enISSN
1535-4989ae974a485f413a2113503eed53cd6c53
10.1165/rcmb.2013-0453TR
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