Longitudinal stability of the diurnal rhythm of intraocular pressure in subjects with healthy eyes, ocular hypertension and pigment dispersion syndrome

Hdl Handle:
http://hdl.handle.net/10147/333816
Title:
Longitudinal stability of the diurnal rhythm of intraocular pressure in subjects with healthy eyes, ocular hypertension and pigment dispersion syndrome
Authors:
Huchzermeyer, Cord; Reulbach, Udo; Horn, Folkert; Lämmer, Robert; Mardin, Christian Y; Jünemann, Anselm GM
Citation:
BMC Ophthalmology. 2014 Oct 15;14(1):122
Issue Date:
15-Oct-2014
URI:
http://dx.doi.org/10.1186/1471-2415-14-122; http://hdl.handle.net/10147/333816
Abstract:
Abstract Background The diurnal fluctuation of intraocular pressure may be relevant in glaucoma. The aim of this study was to find out whether the timing of diurnal fluctuation is stable over the years. Methods Long-term IOP data from the Erlangen Glaucoma Registry, consisting of several annual extended diurnal IOP profiles for each patient, was retrospectively analyzed. Normal subjects, patients with ocular hypertension and with pigment dispersion syndrome were included because these subjects had not been treated with antiglaucomatous medications at the time of data acquisition. A cosine curve was fitted to the IOP data and the stability of individual rhythms over the years was tested using the Rayleigh test. To compare the peak times among groups, means were calculated only from subjects with a significant Rayleigh test. Results Of the fifty-two eligible subjects, a total of 364 extended diurnal IOP profiles measured in a sitting position had been collected over a period of 114 ± 39 months. The Rayleigh test indicated intraindividual stability of phase timing only in 19 subjects (36%). In subjects with pigment dispersions syndrome, peak IOP occurred on average two hours and seven minutes later during the day compared with subjects without this condition (p = 0.05). Conclusions Fitting of cosine curves to the clinical IOP profiles was generally feasible, although careful interpretation is warranted due to lack of measurements in supine position and between midnight and 7 am. The interesting observation of a phase lag in eyes with pigment dispersion syndrome warrants confirmation and exploration in future prospective studies. The analysis of the IOP data showed no stable individual rhythm in the long term in a majority of patients.
Item Type:
Article
Language:
en
Local subject classification:
OPHTHALMOLOGY

Full metadata record

DC FieldValue Language
dc.contributor.authorHuchzermeyer, Corden_GB
dc.contributor.authorReulbach, Udoen_GB
dc.contributor.authorHorn, Folkerten_GB
dc.contributor.authorLämmer, Roberten_GB
dc.contributor.authorMardin, Christian Yen_GB
dc.contributor.authorJünemann, Anselm GMen_GB
dc.date.accessioned2014-11-07T12:29:57Z-
dc.date.available2014-11-07T12:29:57Z-
dc.date.issued2014-10-15-
dc.identifier.citationBMC Ophthalmology. 2014 Oct 15;14(1):122en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2415-14-122-
dc.identifier.urihttp://hdl.handle.net/10147/333816-
dc.description.abstractAbstract Background The diurnal fluctuation of intraocular pressure may be relevant in glaucoma. The aim of this study was to find out whether the timing of diurnal fluctuation is stable over the years. Methods Long-term IOP data from the Erlangen Glaucoma Registry, consisting of several annual extended diurnal IOP profiles for each patient, was retrospectively analyzed. Normal subjects, patients with ocular hypertension and with pigment dispersion syndrome were included because these subjects had not been treated with antiglaucomatous medications at the time of data acquisition. A cosine curve was fitted to the IOP data and the stability of individual rhythms over the years was tested using the Rayleigh test. To compare the peak times among groups, means were calculated only from subjects with a significant Rayleigh test. Results Of the fifty-two eligible subjects, a total of 364 extended diurnal IOP profiles measured in a sitting position had been collected over a period of 114 ± 39 months. The Rayleigh test indicated intraindividual stability of phase timing only in 19 subjects (36%). In subjects with pigment dispersions syndrome, peak IOP occurred on average two hours and seven minutes later during the day compared with subjects without this condition (p = 0.05). Conclusions Fitting of cosine curves to the clinical IOP profiles was generally feasible, although careful interpretation is warranted due to lack of measurements in supine position and between midnight and 7 am. The interesting observation of a phase lag in eyes with pigment dispersion syndrome warrants confirmation and exploration in future prospective studies. The analysis of the IOP data showed no stable individual rhythm in the long term in a majority of patients.-
dc.language.isoenen
dc.subject.otherOPHTHALMOLOGYen_GB
dc.titleLongitudinal stability of the diurnal rhythm of intraocular pressure in subjects with healthy eyes, ocular hypertension and pigment dispersion syndromeen_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderCord Huchzermeyer et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2014-10-23T15:03:25Z-
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