The association between TNF-α and insulin resistance in euglycemic women.

Hdl Handle:
http://hdl.handle.net/10147/333015
Title:
The association between TNF-α and insulin resistance in euglycemic women.
Authors:
Walsh, Jennifer M; McGowan, Ciara A; Byrne, Jacinta A; Rath, Ann; McAuliffe, Fionnuala M
Affiliation:
UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, Ireland; National Maternity Hospital, Dublin, Ireland. Electronic address: msjenniferwalsh@gmail.com.
Citation:
Walsh, J.M. et al., 2013. The association between TNF-α and insulin resistance in euglycemic women. Cytokine, 64 (1), pp 208-12.
Journal:
Cytokine
Issue Date:
Oct-2013
URI:
http://hdl.handle.net/10147/333015
DOI:
10.1016/j.cyto.2013.07.001
PubMed ID:
23953853
Abstract:
Chronic low levels of inflammation have links to obesity, diabetes and insulin resistance. We sought to assess the relationship between cytokine tumor necrosis factor (TNF-α) and insulin resistance in a healthy, euglycemic population. This is a prospective study of 574 non-diabetic mother and infant pairs. Maternal body mass index (BMI), TNF-α, glucose and insulin were measured in early pregnancy and at 28 weeks. Insulin resistance was calculated by HOMA index. At delivery birthweight was recorded and cord blood analysed for fetal C-peptide and TNF-α. In a multivariate model, maternal TNF-α in early pregnancy was predicted by maternal insulin resistance at the same time-point, (β=0.54, p<0.01), and maternal TNF-α at 28 weeks was predicted by maternal insulin resistance in early pregnancy (β=0.24, p<0.01) and at 28 weeks (β=0.39, p<0.01). These results, in a large cohort of healthy, non-diabetic women have shown that insulin resistance, even at levels below those diagnostic of gestational diabetes, is associated with maternal and fetal inflammatory response. These findings have important implications for defining the pathways of fetal programming of later metabolic syndrome and childhood obesity.
Item Type:
Article
Language:
en
Keywords:
MOTHER; INFANT; OBESITY
Local subject classification:
METABOLIC RESPONSE
MeSH:
Adult; Blood Glucose; Body Mass Index; Female; Humans; Infant; Infant, Newborn; Inflammation; Insulin; Insulin Resistance; Pregnancy; Prospective Studies; Tumor Necrosis Factor-alpha
ISSN:
1096-0023

Full metadata record

DC FieldValue Language
dc.contributor.authorWalsh, Jennifer Men_GB
dc.contributor.authorMcGowan, Ciara Aen_GB
dc.contributor.authorByrne, Jacinta Aen_GB
dc.contributor.authorRath, Annen_GB
dc.contributor.authorMcAuliffe, Fionnuala Men_GB
dc.date.accessioned2014-10-21T15:31:00Z-
dc.date.available2014-10-21T15:31:00Z-
dc.date.issued2013-10-
dc.identifier.citationWalsh, J.M. et al., 2013. The association between TNF-α and insulin resistance in euglycemic women. Cytokine, 64 (1), pp 208-12.en_GB
dc.identifier.issn1096-0023-
dc.identifier.pmid23953853-
dc.identifier.doi10.1016/j.cyto.2013.07.001-
dc.identifier.urihttp://hdl.handle.net/10147/333015-
dc.description.abstractChronic low levels of inflammation have links to obesity, diabetes and insulin resistance. We sought to assess the relationship between cytokine tumor necrosis factor (TNF-α) and insulin resistance in a healthy, euglycemic population. This is a prospective study of 574 non-diabetic mother and infant pairs. Maternal body mass index (BMI), TNF-α, glucose and insulin were measured in early pregnancy and at 28 weeks. Insulin resistance was calculated by HOMA index. At delivery birthweight was recorded and cord blood analysed for fetal C-peptide and TNF-α. In a multivariate model, maternal TNF-α in early pregnancy was predicted by maternal insulin resistance at the same time-point, (β=0.54, p<0.01), and maternal TNF-α at 28 weeks was predicted by maternal insulin resistance in early pregnancy (β=0.24, p<0.01) and at 28 weeks (β=0.39, p<0.01). These results, in a large cohort of healthy, non-diabetic women have shown that insulin resistance, even at levels below those diagnostic of gestational diabetes, is associated with maternal and fetal inflammatory response. These findings have important implications for defining the pathways of fetal programming of later metabolic syndrome and childhood obesity.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Cytokineen_GB
dc.subjectMOTHERen_GB
dc.subjectINFANTen_GB
dc.subjectOBESITYen_GB
dc.subject.meshAdult-
dc.subject.meshBlood Glucose-
dc.subject.meshBody Mass Index-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshInfant-
dc.subject.meshInfant, Newborn-
dc.subject.meshInflammation-
dc.subject.meshInsulin-
dc.subject.meshInsulin Resistance-
dc.subject.meshPregnancy-
dc.subject.meshProspective Studies-
dc.subject.meshTumor Necrosis Factor-alpha-
dc.subject.otherMETABOLIC RESPONSEen_GB
dc.titleThe association between TNF-α and insulin resistance in euglycemic women.en_GB
dc.typeArticleen
dc.contributor.departmentUCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, Ireland; National Maternity Hospital, Dublin, Ireland. Electronic address: msjenniferwalsh@gmail.com.en_GB
dc.identifier.journalCytokineen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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