Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD).

Hdl Handle:
http://hdl.handle.net/10147/332799
Title:
Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD).
Authors:
O'Dwyer, David N; Armstrong, Michelle E; Cooke, Gordon; Dodd, Jonathan D; Veale, Douglas J; Donnelly, Seamas C
Affiliation:
School of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland; National Pulmonary Fibrosis Referral Centre at St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Citation:
O'Dwyer, DN et al. Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD). Eur. J. Intern. Med. 2013, 24 (7):597-603
Journal:
European journal of internal medicine
Issue Date:
Oct-2013
URI:
http://hdl.handle.net/10147/332799
DOI:
10.1016/j.ejim.2013.07.004
PubMed ID:
23916467
Abstract:
Rheumatoid Arthritis (RA) is the most common Connective Tissue Disease (CTD) and represents an increasing burden on global health resources. Interstitial lung disease (ILD) has been recognised as a complication of RA but its potential for mortality and morbidity has arguably been under appreciated for decades. New studies have underscored a significant lifetime risk of ILD development in RA. Contemporary work has identified an increased risk of mortality associated with the Usual Interstitial Pneumonia (UIP) pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary Fibrosis (IPF). In this paper, we discuss recent studies highlighting the associated increase in mortality in RA-UIP. We explore associations between radiological and histopathological features of RA-ILD and the prognostic implications of same. We emphasise the need for translational research in this area given the growing burden of RA-ILD. We highlight the importance of the respiratory physician as a key stakeholder in the multidisciplinary management of this disorder. RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this extra articular manifestation. This may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease. We also discuss some of the more challenging and novel aspects of therapy for RA-ILD.
Item Type:
Article
Language:
en
Keywords:
RESPIRATORY DISORDER
Local subject classification:
RHEUMATOID ARTHRITIS; INTERSTITIAL LUNG DISEASE
MeSH:
Arthritis, Rheumatoid; Humans; Lung Diseases, Interstitial; Pulmonary Fibrosis; Risk Factors
ISSN:
1879-0828

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Dwyer, David Nen_GB
dc.contributor.authorArmstrong, Michelle Een_GB
dc.contributor.authorCooke, Gordonen_GB
dc.contributor.authorDodd, Jonathan Den_GB
dc.contributor.authorVeale, Douglas Jen_GB
dc.contributor.authorDonnelly, Seamas Cen_GB
dc.date.accessioned2014-10-16T11:40:21Z-
dc.date.available2014-10-16T11:40:21Z-
dc.date.issued2013-10-
dc.identifier.citationO'Dwyer, DN et al. Rheumatoid Arthritis (RA) associated interstitial lung disease (ILD). Eur. J. Intern. Med. 2013, 24 (7):597-603en_GB
dc.identifier.issn1879-0828-
dc.identifier.pmid23916467-
dc.identifier.doi10.1016/j.ejim.2013.07.004-
dc.identifier.urihttp://hdl.handle.net/10147/332799-
dc.description.abstractRheumatoid Arthritis (RA) is the most common Connective Tissue Disease (CTD) and represents an increasing burden on global health resources. Interstitial lung disease (ILD) has been recognised as a complication of RA but its potential for mortality and morbidity has arguably been under appreciated for decades. New studies have underscored a significant lifetime risk of ILD development in RA. Contemporary work has identified an increased risk of mortality associated with the Usual Interstitial Pneumonia (UIP) pattern which shares similarity with the most devastating of the interstitial pulmonary diseases, namely Idiopathic Pulmonary Fibrosis (IPF). In this paper, we discuss recent studies highlighting the associated increase in mortality in RA-UIP. We explore associations between radiological and histopathological features of RA-ILD and the prognostic implications of same. We emphasise the need for translational research in this area given the growing burden of RA-ILD. We highlight the importance of the respiratory physician as a key stakeholder in the multidisciplinary management of this disorder. RA-ILD focused research offers the opportunity to identify early asymptomatic disease and define the natural history of this extra articular manifestation. This may provide a unique opportunity to define key regulatory fibrotic events driving progressive disease. We also discuss some of the more challenging and novel aspects of therapy for RA-ILD.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to European journal of internal medicineen_GB
dc.subjectRESPIRATORY DISORDERen_GB
dc.subject.meshArthritis, Rheumatoid-
dc.subject.meshHumans-
dc.subject.meshLung Diseases, Interstitial-
dc.subject.meshPulmonary Fibrosis-
dc.subject.meshRisk Factors-
dc.subject.otherRHEUMATOID ARTHRITISen_GB
dc.subject.otherINTERSTITIAL LUNG DISEASEen_GB
dc.titleRheumatoid Arthritis (RA) associated interstitial lung disease (ILD).en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Medicine and Medical Science, College of Life Sciences, UCD Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland; National Pulmonary Fibrosis Referral Centre at St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.en_GB
dc.identifier.journalEuropean journal of internal medicineen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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