The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence.

Hdl Handle:
http://hdl.handle.net/10147/326349
Title:
The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence.
Authors:
Corcoran, Deirdre; Murphy, Deirdre; Donnelly, Jennifer C; Ainle, Fionnuala Ni
Affiliation:
Department of Laboratory Medicine, Rotunda Hospital, Dublin, Ireland.
Citation:
Corcoran D et al. The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence. Blood Transfus. 2014:1-5
Journal:
Blood Transfusion = Trasfusione del sangue
Issue Date:
12-Jun-2014
URI:
http://hdl.handle.net/10147/326349
DOI:
10.2450/2014.0297-13
PubMed ID:
24960639
Abstract:
Acid elution (AE) is used to estimate foeto-maternal haemorrhage (FMH). However AE cannot differentiate between cells containing foetal or adult haemoglobin F (F cells), potentially leading to false positive results or an overestimate of the amount of FMH. The prevalence of F cells in pregnant populations remains poorly characterised. The purpose of this study was to ascertain the incidence of HbF-containing red cells in our pregnant population using anti-HbF-fluorescein isothiocyanate flow cytometry (anti-HbF FC) and to assess whether its presence leads to a significant overestimate of FMH.
Item Type:
Article
Language:
en
Keywords:
PREGNANCY
Local subject classification:
FOETO-MATERNAL HAEMORRHAGE
ISSN:
1723-2007

Full metadata record

DC FieldValue Language
dc.contributor.authorCorcoran, Deirdreen_GB
dc.contributor.authorMurphy, Deirdreen_GB
dc.contributor.authorDonnelly, Jennifer Cen_GB
dc.contributor.authorAinle, Fionnuala Nien_GB
dc.date.accessioned2014-09-22T09:13:01Z-
dc.date.available2014-09-22T09:13:01Z-
dc.date.issued2014-06-12-
dc.identifier.citationCorcoran D et al. The prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence. Blood Transfus. 2014:1-5en_GB
dc.identifier.issn1723-2007-
dc.identifier.pmid24960639-
dc.identifier.doi10.2450/2014.0297-13-
dc.identifier.urihttp://hdl.handle.net/10147/326349-
dc.description.abstractAcid elution (AE) is used to estimate foeto-maternal haemorrhage (FMH). However AE cannot differentiate between cells containing foetal or adult haemoglobin F (F cells), potentially leading to false positive results or an overestimate of the amount of FMH. The prevalence of F cells in pregnant populations remains poorly characterised. The purpose of this study was to ascertain the incidence of HbF-containing red cells in our pregnant population using anti-HbF-fluorescein isothiocyanate flow cytometry (anti-HbF FC) and to assess whether its presence leads to a significant overestimate of FMH.en_GB
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to Blood transfusion = Trasfusione del sangueen_GB
dc.subjectPREGNANCYen_GB
dc.subject.otherFOETO-MATERNAL HAEMORRHAGEen_GB
dc.titleThe prevalence of maternal F cells in a pregnant population and potential overestimation of foeto-maternal haemorrhage as a consequence.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Laboratory Medicine, Rotunda Hospital, Dublin, Ireland.en_GB
dc.identifier.journalBlood Transfusion = Trasfusione del sangueen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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