Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study.

Hdl Handle:
http://hdl.handle.net/10147/325912
Title:
Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study.
Authors:
Tsang, J S; Vencken, S; Sharaf, O; Leen, E; Kay, E W; McNamara, D A; Deasy, J; Mulligan, E D
Affiliation:
Department of Surgical Research, Connolly Hospital & RCSI, Blanchardstown, Dublin, Ireland. Electronic address: julianst@yahoo.com.
Citation:
Tsang JS et al. Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - a pilot study. Eur J Surg Oncol 2014
Journal:
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Issue Date:
28-Jul-2014
URI:
http://hdl.handle.net/10147/325912
DOI:
10.1016/j.ejso.2014.06.008
PubMed ID:
25108814
Abstract:
In rectal cancer, not all tumours display a response to neoadjuvant treatment. An accurate predictor of response does not exist to guide patient-specific treatment. DNA methylation is a distinctive molecular pathway in colorectal carcinogenesis. Whether DNA methylation is altered by neoadjuvant treatment and a potential response predictor is unknown. We aimed to determine whether DNA methylation is altered by neoadjuvant chemoradiotherapy (CRT) and to determine its role in predicting response to treatment.
Item Type:
Article
Language:
en
Keywords:
CANCER; MEDICAL TREATMENT
Local subject classification:
CANCER, RECTAL; CHEMOTHERAPY; RADIOTHERAPY
ISSN:
1532-2157

Full metadata record

DC FieldValue Language
dc.contributor.authorTsang, J Sen_GB
dc.contributor.authorVencken, Sen_GB
dc.contributor.authorSharaf, Oen_GB
dc.contributor.authorLeen, Een_GB
dc.contributor.authorKay, E Wen_GB
dc.contributor.authorMcNamara, D Aen_GB
dc.contributor.authorDeasy, Jen_GB
dc.contributor.authorMulligan, E Den_GB
dc.date.accessioned2014-09-05T14:57:26Z-
dc.date.available2014-09-05T14:57:26Z-
dc.date.issued2014-07-28-
dc.identifier.citationTsang JS et al. Global DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - a pilot study. Eur J Surg Oncol 2014en_GB
dc.identifier.issn1532-2157-
dc.identifier.pmid25108814-
dc.identifier.doi10.1016/j.ejso.2014.06.008-
dc.identifier.urihttp://hdl.handle.net/10147/325912-
dc.description.abstractIn rectal cancer, not all tumours display a response to neoadjuvant treatment. An accurate predictor of response does not exist to guide patient-specific treatment. DNA methylation is a distinctive molecular pathway in colorectal carcinogenesis. Whether DNA methylation is altered by neoadjuvant treatment and a potential response predictor is unknown. We aimed to determine whether DNA methylation is altered by neoadjuvant chemoradiotherapy (CRT) and to determine its role in predicting response to treatment.en_GB
dc.languageENG-
dc.language.isoenen
dc.rightsArchived with thanks to European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncologyen_GB
dc.subjectCANCERen_GB
dc.subjectMEDICAL TREATMENTen_GB
dc.subject.otherCANCER, RECTALen_GB
dc.subject.otherCHEMOTHERAPYen_GB
dc.subject.otherRADIOTHERAPYen_GB
dc.titleGlobal DNA methylation is altered by neoadjuvant chemoradiotherapy in rectal cancer and may predict response to treatment - A pilot study.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Surgical Research, Connolly Hospital & RCSI, Blanchardstown, Dublin, Ireland. Electronic address: julianst@yahoo.com.en_GB
dc.identifier.journalEuropean journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncologyen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

Related articles on PubMed

All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.