Exposure to low dose ionising radiation: Molecular and clinical consequences.

Hdl Handle:
http://hdl.handle.net/10147/324509
Title:
Exposure to low dose ionising radiation: Molecular and clinical consequences.
Authors:
Martin, Lynn M; Marples, Brian; Lynch, Thomas H; Hollywood, Donal; Marignol, Laure
Citation:
Martin LM et al. Exposure to low dose ionising radiation: molecular and clinical consequences. Cancer Lett. 2014, 349 (1):98-106
Journal:
Cancer letters
Issue Date:
10-Jul-2014
URI:
http://hdl.handle.net/10147/324509
PubMed ID:
24983100
Abstract:
This review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.
Item Type:
Article
Language:
en
Keywords:
RADIATION
Local subject classification:
CELL BIOLOGY
ISSN:
1872-7980

Full metadata record

DC FieldValue Language
dc.contributor.authorMartin, Lynn Men_GB
dc.contributor.authorMarples, Brianen_GB
dc.contributor.authorLynch, Thomas Hen_GB
dc.contributor.authorHollywood, Donalen_GB
dc.contributor.authorMarignol, Laureen_GB
dc.date.accessioned2014-08-08T11:39:47Z-
dc.date.available2014-08-08T11:39:47Z-
dc.date.issued2014-07-10-
dc.identifier.citationMartin LM et al. Exposure to low dose ionising radiation: molecular and clinical consequences. Cancer Lett. 2014, 349 (1):98-106en_GB
dc.identifier.issn1872-7980-
dc.identifier.pmid24983100-
dc.identifier.urihttp://hdl.handle.net/10147/324509-
dc.description.abstractThis review article provides a comprehensive overview of the experimental data detailing the incidence, mechanism and significance of low dose hyper-radiosensitivity (HRS). Important discoveries gained from past and present studies are mapped and highlighted to illustrate the pathway to our current understanding of HRS and the impact of HRS on the cellular response to radiation in mammalian cells. Particular attention is paid to the balance of evidence suggesting a role for DNA repair processes in the response, evidence suggesting a role for the cell cycle checkpoint processes, and evidence investigating the clinical implications/relevance of the effect.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Cancer lettersen_GB
dc.subjectRADIATIONen_GB
dc.subject.otherCELL BIOLOGYen_GB
dc.titleExposure to low dose ionising radiation: Molecular and clinical consequences.en_GB
dc.typeArticleen
dc.identifier.journalCancer lettersen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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