Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity: secondary analysis from the ROLO study

Hdl Handle:
http://hdl.handle.net/10147/324350
Title:
Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity: secondary analysis from the ROLO study
Authors:
Horan, Mary K; McGowan, Ciara A; Gibney, Eileen R; Donnelly, Jean M; McAuliffe, Fionnuala M
Citation:
Horan MK et al. Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity: secondary analysis from the ROLO study. Nutr J. 2014 Aug 01;13(1):78
Issue Date:
1-Aug-2014
URI:
http://dx.doi.org/10.1186/1475-2891-13-78; http://hdl.handle.net/10147/324350
Abstract:
Abstract Background The in utero environment is known to affect fetal development however many of the mechanisms by which this occurs remain unknown. The aim of this study was to examine the association between maternal dietary macronutrient intake and lifestyle throughout pregnancy and neonatal weight and adiposity. Methods This was an analysis of 542 mother and infant pairs from the ROLO study (Randomised cOntrol trial of LOw glycaemic index diet versus no dietary intervention to prevent recurrence of fetal macrosomia). Food diaries as well as food frequency and lifestyle and physical activity questionnaires were completed during pregnancy. Maternal anthropometry was measured throughout pregnancy and neonatal anthropometry was measured at birth. Results Multiple linear regression analysis revealed the main maternal factor associated with increased birth weight was greater gestational weight gain R2 adj23.3% (F = 11.547, p < 0.001). The main maternal factor associated with increased birth length was non-smoking status R2 adj27.8% (F = 6.193, p < 0.001). Neonatal central adiposity (determined using waist:length ratio) was negatively associated with maternal age, and positively associated with the following parameters: smoking status, maternal pre-pregnancy arm circumference, percentage energy from saturated fat in late pregnancy, postprandial glucose at 28 weeks gestation and membership of the control group with a positive trend towards association with trimester 2 glycaemic load R2 adj 38.1% (F = 8.000, p < 0.001). Conclusions Several maternal diet and lifestyle factors were associated with neonatal anthropometry . Low glycaemic index dietary intervention in pregnancy was found to have a beneficial effect on neonatal central adiposity. Additionally, central adiposity was positively associated with maternal dietary fat intake and postprandial glucose highlighting the important role of healthy diet in pregnancy in promoting normal neonatal adiposity. Trial registration Current Controlled Trials ISRCTN54392969.
Item Type:
Article
Language:
en
Keywords:
NEONATE; NUTRITION; MOTHER

Full metadata record

DC FieldValue Language
dc.contributor.authorHoran, Mary Ken_GB
dc.contributor.authorMcGowan, Ciara Aen_GB
dc.contributor.authorGibney, Eileen Ren_GB
dc.contributor.authorDonnelly, Jean Men_GB
dc.contributor.authorMcAuliffe, Fionnuala Men_GB
dc.date.accessioned2014-08-07T14:40:12Z-
dc.date.available2014-08-07T14:40:12Z-
dc.date.issued2014-08-01-
dc.identifier.citationHoran MK et al. Maternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity: secondary analysis from the ROLO study. Nutr J. 2014 Aug 01;13(1):78en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1475-2891-13-78-
dc.identifier.urihttp://hdl.handle.net/10147/324350-
dc.description.abstractAbstract Background The in utero environment is known to affect fetal development however many of the mechanisms by which this occurs remain unknown. The aim of this study was to examine the association between maternal dietary macronutrient intake and lifestyle throughout pregnancy and neonatal weight and adiposity. Methods This was an analysis of 542 mother and infant pairs from the ROLO study (Randomised cOntrol trial of LOw glycaemic index diet versus no dietary intervention to prevent recurrence of fetal macrosomia). Food diaries as well as food frequency and lifestyle and physical activity questionnaires were completed during pregnancy. Maternal anthropometry was measured throughout pregnancy and neonatal anthropometry was measured at birth. Results Multiple linear regression analysis revealed the main maternal factor associated with increased birth weight was greater gestational weight gain R2 adj23.3% (F = 11.547, p < 0.001). The main maternal factor associated with increased birth length was non-smoking status R2 adj27.8% (F = 6.193, p < 0.001). Neonatal central adiposity (determined using waist:length ratio) was negatively associated with maternal age, and positively associated with the following parameters: smoking status, maternal pre-pregnancy arm circumference, percentage energy from saturated fat in late pregnancy, postprandial glucose at 28 weeks gestation and membership of the control group with a positive trend towards association with trimester 2 glycaemic load R2 adj 38.1% (F = 8.000, p < 0.001). Conclusions Several maternal diet and lifestyle factors were associated with neonatal anthropometry . Low glycaemic index dietary intervention in pregnancy was found to have a beneficial effect on neonatal central adiposity. Additionally, central adiposity was positively associated with maternal dietary fat intake and postprandial glucose highlighting the important role of healthy diet in pregnancy in promoting normal neonatal adiposity. Trial registration Current Controlled Trials ISRCTN54392969.-
dc.language.isoenen
dc.subjectNEONATEen_GB
dc.subjectNUTRITIONen_GB
dc.subjectMOTHERen_GB
dc.titleMaternal low glycaemic index diet, fat intake and postprandial glucose influences neonatal adiposity: secondary analysis from the ROLO studyen_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderMary K Horan et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2014-08-07T11:10:14Z-
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