Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation.

Hdl Handle:
http://hdl.handle.net/10147/324092
Title:
Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation.
Authors:
Aherne, Noel J; Rangaswamy, Guhan; Thirion, Pierre
Affiliation:
Department of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour, NSW 2450, Australia.
Citation:
Aherne NJ, Rangaswamy G, Thirion P. Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation. Case Rep Urol. 2013, 2013:405343 Case Rep Urol
Publisher:
Hindawi Publishing Corp.
Journal:
Case reports in urology
Issue Date:
5-Aug-2013
URI:
http://hdl.handle.net/10147/324092
DOI:
10.1155/2013/405343
PubMed ID:
23984174
Abstract:
Holt-Oram syndrome is an autosomal dominant disorder which is caused by mutations of TBX5 and is characterised by cardiac and skeletal abnormalities. TBX5 is part of the T-box gene family and is thought to upregulate tumour cell proliferation and metastasis when mutated. We report the first clinical case of prostate cancer in an individual with Holt Oram syndrome.
Item Type:
Article
Language:
en
Keywords:
PROSTATE CANCER; GENETICS
Local subject classification:
HOLT-ORAM SYNDROME
ISSN:
2090-696X

Full metadata record

DC FieldValue Language
dc.contributor.authorAherne, Noel Jen_GB
dc.contributor.authorRangaswamy, Guhanen_GB
dc.contributor.authorThirion, Pierreen_GB
dc.date.accessioned2014-08-01T11:31:21Z-
dc.date.available2014-08-01T11:31:21Z-
dc.date.issued2013-08-05-
dc.identifier.citationAherne NJ, Rangaswamy G, Thirion P. Prostate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation. Case Rep Urol. 2013, 2013:405343 Case Rep Urolen_GB
dc.identifier.issn2090-696X-
dc.identifier.pmid23984174-
dc.identifier.doi10.1155/2013/405343-
dc.identifier.urihttp://hdl.handle.net/10147/324092-
dc.description.abstractHolt-Oram syndrome is an autosomal dominant disorder which is caused by mutations of TBX5 and is characterised by cardiac and skeletal abnormalities. TBX5 is part of the T-box gene family and is thought to upregulate tumour cell proliferation and metastasis when mutated. We report the first clinical case of prostate cancer in an individual with Holt Oram syndrome.en_GB
dc.language.isoenen
dc.publisherHindawi Publishing Corp.en_GB
dc.rightsArchived with thanks to Case reports in urologyen_GB
dc.subjectPROSTATE CANCERen_GB
dc.subjectGENETICSen_GB
dc.subject.otherHOLT-ORAM SYNDROMEen_GB
dc.titleProstate cancer in a male with Holt-Oram syndrome: first clinical association of the TBX5 mutation.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Radiation Oncology, North Coast Cancer Institute, Coffs Harbour, NSW 2450, Australia.en_GB
dc.identifier.journalCase reports in urologyen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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