The role of osteoblasts in peri-prosthetic osteolysis.

Hdl Handle:
http://hdl.handle.net/10147/324033
Title:
The role of osteoblasts in peri-prosthetic osteolysis.
Authors:
O'Neill, S C; Queally, J M; Devitt, B M; Doran, P P; O'Byrne, J M
Affiliation:
Cappagh National Orthopaedic Hospital, Finglas, Dublin, Ireland.
Citation:
O'Neill SC et al. The role of osteoblasts in peri-prosthetic osteolysis. 2013, 95-B (8):1022-6 Bone Joint J
Publisher:
The bone & joint journal
Journal:
The bone & joint journal
Issue Date:
Aug-2013
URI:
http://hdl.handle.net/10147/324033
DOI:
10.1302/0301-620X.95B8.31229
PubMed ID:
23908414
Abstract:
Peri-prosthetic osteolysis and subsequent aseptic loosening is the most common reason for revising total hip replacements. Wear particles originating from the prosthetic components interact with multiple cell types in the peri-prosthetic region resulting in an inflammatory process that ultimately leads to peri-prosthetic bone loss. These cells include macrophages, osteoclasts, osteoblasts and fibroblasts. The majority of research in peri-prosthetic osteolysis has concentrated on the role played by osteoclasts and macrophages. The purpose of this review is to assess the role of the osteoblast in peri-prosthetic osteolysis. In peri-prosthetic osteolysis, wear particles may affect osteoblasts and contribute to the osteolytic process by two mechanisms. First, particles and metallic ions have been shown to inhibit the osteoblast in terms of its ability to secrete mineralised bone matrix, by reducing calcium deposition, alkaline phosphatase activity and its ability to proliferate. Secondly, particles and metallic ions have been shown to stimulate osteoblasts to produce pro inflammatory mediators in vitro. In vivo, these mediators have the potential to attract pro-inflammatory cells to the peri-prosthetic area and stimulate osteoclasts to absorb bone. Further research is needed to fully define the role of the osteoblast in peri-prosthetic osteolysis and to explore its potential role as a therapeutic target in this condition.
Item Type:
Article
Language:
en
Keywords:
SURGERY
Local subject classification:
SURGERY, ORTHOPAEDIC; HIP REPLACEMENT
MeSH:
Arthroplasty, Replacement, Hip; Cytokines; Hip Prosthesis; Humans; Inflammation Mediators; Osteoblasts; Osteolysis; Prosthesis Failure
ISSN:
2049-4408

Full metadata record

DC FieldValue Language
dc.contributor.authorO'Neill, S Cen_GB
dc.contributor.authorQueally, J Men_GB
dc.contributor.authorDevitt, B Men_GB
dc.contributor.authorDoran, P Pen_GB
dc.contributor.authorO'Byrne, J Men_GB
dc.date.accessioned2014-07-31T08:26:47Z-
dc.date.available2014-07-31T08:26:47Z-
dc.date.issued2013-08-
dc.identifier.citationO'Neill SC et al. The role of osteoblasts in peri-prosthetic osteolysis. 2013, 95-B (8):1022-6 Bone Joint Jen_GB
dc.identifier.issn2049-4408-
dc.identifier.pmid23908414-
dc.identifier.doi10.1302/0301-620X.95B8.31229-
dc.identifier.urihttp://hdl.handle.net/10147/324033-
dc.description.abstractPeri-prosthetic osteolysis and subsequent aseptic loosening is the most common reason for revising total hip replacements. Wear particles originating from the prosthetic components interact with multiple cell types in the peri-prosthetic region resulting in an inflammatory process that ultimately leads to peri-prosthetic bone loss. These cells include macrophages, osteoclasts, osteoblasts and fibroblasts. The majority of research in peri-prosthetic osteolysis has concentrated on the role played by osteoclasts and macrophages. The purpose of this review is to assess the role of the osteoblast in peri-prosthetic osteolysis. In peri-prosthetic osteolysis, wear particles may affect osteoblasts and contribute to the osteolytic process by two mechanisms. First, particles and metallic ions have been shown to inhibit the osteoblast in terms of its ability to secrete mineralised bone matrix, by reducing calcium deposition, alkaline phosphatase activity and its ability to proliferate. Secondly, particles and metallic ions have been shown to stimulate osteoblasts to produce pro inflammatory mediators in vitro. In vivo, these mediators have the potential to attract pro-inflammatory cells to the peri-prosthetic area and stimulate osteoclasts to absorb bone. Further research is needed to fully define the role of the osteoblast in peri-prosthetic osteolysis and to explore its potential role as a therapeutic target in this condition.en_GB
dc.language.isoenen
dc.publisherThe bone & joint journalen_GB
dc.rightsArchived with thanks to The bone & joint journalen_GB
dc.subjectSURGERYen_GB
dc.subject.meshArthroplasty, Replacement, Hip-
dc.subject.meshCytokines-
dc.subject.meshHip Prosthesis-
dc.subject.meshHumans-
dc.subject.meshInflammation Mediators-
dc.subject.meshOsteoblasts-
dc.subject.meshOsteolysis-
dc.subject.meshProsthesis Failure-
dc.subject.otherSURGERY, ORTHOPAEDICen_GB
dc.subject.otherHIP REPLACEMENTen_GB
dc.titleThe role of osteoblasts in peri-prosthetic osteolysis.en_GB
dc.typeArticleen
dc.contributor.departmentCappagh National Orthopaedic Hospital, Finglas, Dublin, Ireland.en_GB
dc.identifier.journalThe bone & joint journalen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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