Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery
- Hdl Handle:
- http://hdl.handle.net/10147/323764
- Title:
- Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery
- Authors:
- Publisher:
- Issue Date:
- 2012
- URI:
- http://hdl.handle.net/10147/323764
- Item Type:
- Study
- Language:
- en
- Description:
- Patients requiring major vascular surgery for end-stage vascular disease constitute a high-risk surgical cohort. Peri-operative complications such as myocardial infarction, cerebrovascular accident, renal failure and death are common [1, 2]. Multiple potential mechanisms may result in these complications. For example, myocardial injury may result from systemic hypotension leading to reduced flow across a tight coronary artery stenosis or, alternatively, it may arise due to acute occlusion when an unstable plaque ruptures. Most strategies aimed at peri-operative risk reduction target a single potential mechanism. Thus, for example, beta-blockade may prevent myocardial injury due to overwork, but cannot prevent acute coronary occlusion. There is a requirement for a simple, effective intervention that protects tissues against injury via multiple different mechanisms. Remote ischaemic preconditioning (RIPC) may be suitable.
- Keywords:
- Local subject classification:
- VASCULAR DISEASE
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Walsh, Stewart R | en_GB |
dc.date.accessioned | 2014-07-24T13:46:00Z | - |
dc.date.available | 2014-07-24T13:46:00Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://hdl.handle.net/10147/323764 | - |
dc.description | Patients requiring major vascular surgery for end-stage vascular disease constitute a high-risk surgical cohort. Peri-operative complications such as myocardial infarction, cerebrovascular accident, renal failure and death are common [1, 2]. Multiple potential mechanisms may result in these complications. For example, myocardial injury may result from systemic hypotension leading to reduced flow across a tight coronary artery stenosis or, alternatively, it may arise due to acute occlusion when an unstable plaque ruptures. Most strategies aimed at peri-operative risk reduction target a single potential mechanism. Thus, for example, beta-blockade may prevent myocardial injury due to overwork, but cannot prevent acute coronary occlusion. There is a requirement for a simple, effective intervention that protects tissues against injury via multiple different mechanisms. Remote ischaemic preconditioning (RIPC) may be suitable. | en_GB |
dc.language.iso | en | en |
dc.publisher | University of Limerick (UL) | en_GB |
dc.subject | SURGERY | en_GB |
dc.subject.other | VASCULAR DISEASE | en_GB |
dc.title | Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery | en_GB |
dc.type | Study | en |
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