Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery

Hdl Handle:: http://hdl.handle.net/10147/323764
Title:: Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery
Authors:: Walsh, Stewart R
Publisher:: University of Limerick (UL)
Issue Date:: 2012
URI:: http://hdl.handle.net/10147/323764
Item Type:: Study
Language:: en
Description:: Patients requiring major vascular surgery for end-stage vascular disease constitute a high-risk surgical cohort. Peri-operative complications such as myocardial infarction, cerebrovascular accident, renal failure and death are common [1, 2]. Multiple potential mechanisms may result in these complications. For example, myocardial injury may result from systemic hypotension leading to reduced flow across a tight coronary artery stenosis or, alternatively, it may arise due to acute occlusion when an unstable plaque ruptures. Most strategies aimed at peri-operative risk reduction target a single potential mechanism. Thus, for example, beta-blockade may prevent myocardial injury due to overwork, but cannot prevent acute coronary occlusion. There is a requirement for a simple, effective intervention that protects tissues against injury via multiple different mechanisms. Remote ischaemic preconditioning (RIPC) may be suitable.
Keywords:: SURGERY
Local subject classification:: VASCULAR DISEASE

Full metadata record

DC Field	Value	Language
dc.contributor.author	Walsh, Stewart R	en_GB
dc.date.accessioned	2014-07-24T13:46:00Z	-
dc.date.available	2014-07-24T13:46:00Z	-
dc.date.issued	2012	-
dc.identifier.uri	http://hdl.handle.net/10147/323764	-
dc.description	Patients requiring major vascular surgery for end-stage vascular disease constitute a high-risk surgical cohort. Peri-operative complications such as myocardial infarction, cerebrovascular accident, renal failure and death are common [1, 2]. Multiple potential mechanisms may result in these complications. For example, myocardial injury may result from systemic hypotension leading to reduced flow across a tight coronary artery stenosis or, alternatively, it may arise due to acute occlusion when an unstable plaque ruptures. Most strategies aimed at peri-operative risk reduction target a single potential mechanism. Thus, for example, beta-blockade may prevent myocardial injury due to overwork, but cannot prevent acute coronary occlusion. There is a requirement for a simple, effective intervention that protects tissues against injury via multiple different mechanisms. Remote ischaemic preconditioning (RIPC) may be suitable.	en_GB
dc.language.iso	en	en
dc.publisher	University of Limerick (UL)	en_GB
dc.subject	SURGERY	en_GB
dc.subject.other	VASCULAR DISEASE	en_GB
dc.title	Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery	en_GB
dc.type	Study	en