Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery

Hdl Handle:
http://hdl.handle.net/10147/323764
Title:
Preconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgery
Authors:
Walsh, Stewart R
Publisher:
University of Limerick (UL)
Issue Date:
2012
URI:
http://hdl.handle.net/10147/323764
Item Type:
Study
Language:
en
Description:
Patients requiring major vascular surgery for end-stage vascular disease constitute a high-risk surgical cohort. Peri-operative complications such as myocardial infarction, cerebrovascular accident, renal failure and death are common [1, 2]. Multiple potential mechanisms may result in these complications. For example, myocardial injury may result from systemic hypotension leading to reduced flow across a tight coronary artery stenosis or, alternatively, it may arise due to acute occlusion when an unstable plaque ruptures. Most strategies aimed at peri-operative risk reduction target a single potential mechanism. Thus, for example, beta-blockade may prevent myocardial injury due to overwork, but cannot prevent acute coronary occlusion. There is a requirement for a simple, effective intervention that protects tissues against injury via multiple different mechanisms. Remote ischaemic preconditioning (RIPC) may be suitable.
Keywords:
SURGERY
Local subject classification:
VASCULAR DISEASE

Full metadata record

DC FieldValue Language
dc.contributor.authorWalsh, Stewart Ren_GB
dc.date.accessioned2014-07-24T13:46:00Z-
dc.date.available2014-07-24T13:46:00Z-
dc.date.issued2012-
dc.identifier.urihttp://hdl.handle.net/10147/323764-
dc.descriptionPatients requiring major vascular surgery for end-stage vascular disease constitute a high-risk surgical cohort. Peri-operative complications such as myocardial infarction, cerebrovascular accident, renal failure and death are common [1, 2]. Multiple potential mechanisms may result in these complications. For example, myocardial injury may result from systemic hypotension leading to reduced flow across a tight coronary artery stenosis or, alternatively, it may arise due to acute occlusion when an unstable plaque ruptures. Most strategies aimed at peri-operative risk reduction target a single potential mechanism. Thus, for example, beta-blockade may prevent myocardial injury due to overwork, but cannot prevent acute coronary occlusion. There is a requirement for a simple, effective intervention that protects tissues against injury via multiple different mechanisms. Remote ischaemic preconditioning (RIPC) may be suitable.en_GB
dc.language.isoenen
dc.publisherUniversity of Limerick (UL)en_GB
dc.subjectSURGERYen_GB
dc.subject.otherVASCULAR DISEASEen_GB
dc.titlePreconditioning Shields Against Vascular Events in Surgery (Preconditioning-SAVES): A Pilot Multi-Centre Trial of Preconditioning Against Adverse Events in Major Vascular Surgeryen_GB
dc.typeStudyen
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