Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.

Hdl Handle:
http://hdl.handle.net/10147/323651
Title:
Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.
Authors:
Doherty, Ben; Lawlor, Denise; Gillet, Jean-Pierre; Gottesman, Michael; O'Leary, John J; Stordal, Britta
Affiliation:
Department of Histopathology, Trinity College Dublin, 1.18 Sir Patrick Dun Research Laboratory, Central Pathology Building, St James' Hospital, Dublin 8, Ireland. stordalb@tcd.ie.
Citation:
Doherty B et al. Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells. Anticancer Res. 2014, 34 (1):503-7
Journal:
Anticancer research
Issue Date:
Jan-2014
URI:
http://hdl.handle.net/10147/323651
PubMed ID:
24403508
Abstract:
KB-8-5-11 cells are a drug-resistant cervical cell model that overexpresses ABCB1 (P-glycoprotein). KB-8-5-11 has become sensitive to non-ABCB1 substrate cisplatin. Understanding the mechanism of collateral sensitivity to cisplatin may lead to biomarker discovery for platinum sensitivity in patients with cancer.
Item Type:
Article
Language:
en
Keywords:
CANCER
Local subject classification:
CELL BIOLOGY
MeSH:
Adenosine Triphosphatases; Antineoplastic Agents; Blotting, Western; Cation Transport Proteins; Cell Proliferation; Cisplatin; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Glutathione; Glutathione S-Transferase pi; Glutathione Transferase; Humans; Metabolomics; P-Glycoprotein; RNA, Messenger; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tumor Cells, Cultured; Uterine Cervical Neoplasms
ISSN:
1791-7530

Full metadata record

DC FieldValue Language
dc.contributor.authorDoherty, Benen_GB
dc.contributor.authorLawlor, Deniseen_GB
dc.contributor.authorGillet, Jean-Pierreen_GB
dc.contributor.authorGottesman, Michaelen_GB
dc.contributor.authorO'Leary, John Jen_GB
dc.contributor.authorStordal, Brittaen_GB
dc.date.accessioned2014-07-23T11:53:01Z-
dc.date.available2014-07-23T11:53:01Z-
dc.date.issued2014-01-
dc.identifier.citationDoherty B et al. Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells. Anticancer Res. 2014, 34 (1):503-7en_GB
dc.identifier.issn1791-7530-
dc.identifier.pmid24403508-
dc.identifier.urihttp://hdl.handle.net/10147/323651-
dc.description.abstractKB-8-5-11 cells are a drug-resistant cervical cell model that overexpresses ABCB1 (P-glycoprotein). KB-8-5-11 has become sensitive to non-ABCB1 substrate cisplatin. Understanding the mechanism of collateral sensitivity to cisplatin may lead to biomarker discovery for platinum sensitivity in patients with cancer.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Anticancer researchen_GB
dc.subjectCANCERen_GB
dc.subject.meshAdenosine Triphosphatases-
dc.subject.meshAntineoplastic Agents-
dc.subject.meshBlotting, Western-
dc.subject.meshCation Transport Proteins-
dc.subject.meshCell Proliferation-
dc.subject.meshCisplatin-
dc.subject.meshDrug Resistance, Neoplasm-
dc.subject.meshFemale-
dc.subject.meshGene Expression Regulation, Neoplastic-
dc.subject.meshGlutathione-
dc.subject.meshGlutathione S-Transferase pi-
dc.subject.meshGlutathione Transferase-
dc.subject.meshHumans-
dc.subject.meshMetabolomics-
dc.subject.meshP-Glycoprotein-
dc.subject.meshRNA, Messenger-
dc.subject.meshReal-Time Polymerase Chain Reaction-
dc.subject.meshReverse Transcriptase Polymerase Chain Reaction-
dc.subject.meshTumor Cells, Cultured-
dc.subject.meshUterine Cervical Neoplasms-
dc.subject.otherCELL BIOLOGYen_GB
dc.titleCollateral sensitivity to cisplatin in KB-8-5-11 drug-resistant cancer cells.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Histopathology, Trinity College Dublin, 1.18 Sir Patrick Dun Research Laboratory, Central Pathology Building, St James' Hospital, Dublin 8, Ireland. stordalb@tcd.ie.en_GB
dc.identifier.journalAnticancer researchen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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