Neural tube defects in the Republic of Ireland in 2009-11.

Hdl Handle:
http://hdl.handle.net/10147/323423
Title:
Neural tube defects in the Republic of Ireland in 2009-11.
Authors:
McDonnell, R; Delany, V; O'Mahony, M T; Mullaney, C; Lee, B; Turner, M J
Affiliation:
Health Intelligence Unit, Health Service Executive, Dr Steevens Hospital, Dublin 8, Ireland.
Citation:
McDonnell R et al. Neural tube defects in the Republic of Ireland in 2009-11. J Public Health (Oxf) 2014 Mar 18 [published online]
Journal:
Journal of public health (Oxford, England)
Issue Date:
18-Mar-2014
URI:
http://hdl.handle.net/10147/323423
DOI:
10.1093/pubmed/fdu016
PubMed ID:
24643675
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/24643675
Abstract:
Neural tube defects (NTDs) are associated with deficient maternal folic acid peri-conceptionally. In Ireland, there is no mandatory folic acid food fortification, partly due to declining NTD rates in recent years. The aim of this study was to ascertain the incident rate of NTD during the period 2009-11 and describe epidemiologically NTD in Ireland.METHODSCases were ascertained through multiple sources, including three regional congenital anomaly registers, all maternity hospitals nationally and paediatric hospitals providing care for children with spina bifida in the Republic of Ireland during the period 2009-11.RESULTSFrom 225 998 total births, 236 NTDs were identified, giving an incidence of 1.04/1 000 births, increasing from 0.92/1 000 in 2009 to 1.17/1 000 in 2011. Of all cases, 45% (n = 106) had anencephaly, 49% (n = 115) had spina bifida and 6% (n = 15) had an encephalocoele; 78% (n = 184) were liveborn or stillborn and 22% (n = 52) were terminations abroad. Peri-conceptional folic acid supplement intake was 13.7% among the 52.5% (n = 124) of cases whose folic acid supplement intake was known.CONCLUSIONThe incidence of NTDs in the Republic of Ireland appears to be increasing. Renewed public health interventions, including mandatory folic acid food fortification, must be considered to reduce the incidence of NTD.
Item Type:
Article
Language:
en
Keywords:
SPINA BIFIDA; FOLIC ACID
Local subject classification:
PUBLIC HEALTH DEPARTMENT; CONGENITAL ANOMALY; HEALTH IMPROVEMENT
ISSN:
1741-3850

Full metadata record

DC FieldValue Language
dc.contributor.authorMcDonnell, Ren_GB
dc.contributor.authorDelany, Ven_GB
dc.contributor.authorO'Mahony, M Ten_GB
dc.contributor.authorMullaney, Cen_GB
dc.contributor.authorLee, Ben_GB
dc.contributor.authorTurner, M Jen_GB
dc.date.accessioned2014-07-18T11:09:05Zen
dc.date.available2014-07-18T11:09:05Zen
dc.date.issued2014-03-18en
dc.identifier.citationMcDonnell R et al. Neural tube defects in the Republic of Ireland in 2009-11. J Public Health (Oxf) 2014 Mar 18 [published online]en_GB
dc.identifier.issn1741-3850en
dc.identifier.pmid24643675en
dc.identifier.doi10.1093/pubmed/fdu016en
dc.identifier.urihttp://hdl.handle.net/10147/323423en
dc.description.abstractNeural tube defects (NTDs) are associated with deficient maternal folic acid peri-conceptionally. In Ireland, there is no mandatory folic acid food fortification, partly due to declining NTD rates in recent years. The aim of this study was to ascertain the incident rate of NTD during the period 2009-11 and describe epidemiologically NTD in Ireland.METHODSCases were ascertained through multiple sources, including three regional congenital anomaly registers, all maternity hospitals nationally and paediatric hospitals providing care for children with spina bifida in the Republic of Ireland during the period 2009-11.RESULTSFrom 225 998 total births, 236 NTDs were identified, giving an incidence of 1.04/1 000 births, increasing from 0.92/1 000 in 2009 to 1.17/1 000 in 2011. Of all cases, 45% (n = 106) had anencephaly, 49% (n = 115) had spina bifida and 6% (n = 15) had an encephalocoele; 78% (n = 184) were liveborn or stillborn and 22% (n = 52) were terminations abroad. Peri-conceptional folic acid supplement intake was 13.7% among the 52.5% (n = 124) of cases whose folic acid supplement intake was known.CONCLUSIONThe incidence of NTDs in the Republic of Ireland appears to be increasing. Renewed public health interventions, including mandatory folic acid food fortification, must be considered to reduce the incidence of NTD.en
dc.languageENGen
dc.language.isoenen
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/24643675en_GB
dc.rightsArchived with thanks to Journal of public health (Oxford, England)en_GB
dc.subjectSPINA BIFIDAen_GB
dc.subjectFOLIC ACIDen_GB
dc.subject.otherPUBLIC HEALTH DEPARTMENTen
dc.subject.otherCONGENITAL ANOMALYen
dc.subject.otherHEALTH IMPROVEMENTen
dc.titleNeural tube defects in the Republic of Ireland in 2009-11.en_GB
dc.typeArticleen
dc.contributor.departmentHealth Intelligence Unit, Health Service Executive, Dr Steevens Hospital, Dublin 8, Ireland.en_GB
dc.identifier.journalJournal of public health (Oxford, England)en_GB

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