Recent decrease in the prevalence of congenital heart defects in Europe

Hdl Handle:
http://hdl.handle.net/10147/323407
Title:
Recent decrease in the prevalence of congenital heart defects in Europe
Authors:
Khoshnood, Babak; Loane, Maria; Garne, Ester; Addor, Marie-Claude; Arriola, Larraitz; Bakker, Marian; Barisic, Ingeborg; Bianca, Sebastiano; Boyd, Patricia; Calzolari, Elisa; Doray, Berenice; Draper, Elizabeth; Gatt, Miriam; Haeusler, Martin; Melve, Kari Klungsoyr; Latos-Bielenska, Anna; McDonnell, Bob; Mullaney, Carmel; Nelen, Vera; O'Mahony, Mary; Pierini, Anna; Queisser-Luft, Annette; Randrianaivo, Hanitra; Rankin, Judith; Rissmann, Anke; Salvador, Joaquin; Tucker, David; Verellen-Dumoulin, Christine; Wellesley, Diana; Zymak-Zakutnya, Natalya; Dolk, Helen
Citation:
Khoshnood B et al. Recent decrease in the prevalence of congenital heart defects in Europe. J Ped 2013, 162 (1):108
Journal:
Journal of pediatrics
Issue Date:
18-Jul-2014
URI:
http://hdl.handle.net/10147/323407
DOI:
10.1016/j.jpeds.2012.06.035
Additional Links:
http://linkinghub.elsevier.com/retrieve/pii/S0022347612006762; http://www.ncbi.nlm.nih.gov/pubmed/22835879
Item Type:
Article
Language:
en
Description:
OBJECTIVES: To examine trends in the prevalence of congenital heart defects (CHDs) in Europe and to compare these trends with the recent decrease in the prevalence of CHDs in Canada (Quebec) that was attributed to the policy of mandatory folic acid fortification. STUDY DESIGN: We used data for the period 1990-2007 for 47 508 cases of CHD not associated with a chromosomal anomaly from 29 population-based European Surveillance of Congenital Anomalies registries in 16 countries covering 7.3 million births. We estimated trends for all CHDs combined and separately for 3 severity groups using random-effects Poisson regression models with splines. RESULTS: We found that the total prevalence of CHDs increased during the 1990s and the early 2000s until 2004 and decreased thereafter. We found essentially no trend in total prevalence of the most severe group (group I), whereas the prevalence of severity group II increased until about 2000 and decreased thereafter. Trends for severity group III (the most prevalent group) paralleled those for all CHDs combined. CONCLUSIONS: The prevalence of CHDs decreased in recent years in Europe in the absence of a policy for mandatory folic acid fortification. One possible explanation for this decrease may be an as-yet-undocumented increase in folic acid intake of women in Europe following recommendations for folic acid supplementation and/or voluntary fortification. However, alternative hypotheses, including reductions in risk factors of CHDs (eg, maternal smoking) and improved management of maternal chronic health conditions (eg, diabetes), must also be considered for explaining the observed decrease in the prevalence of CHDs in Europe or elsewhere. Copyright © 2013 Mosby, Inc. All rights reserved.
Keywords:
CHILD HEALTH
Local subject classification:
HEART DEFECTS, CONGENITAL
ISSN:
00223476

Full metadata record

DC FieldValue Language
dc.contributor.authorKhoshnood, Babaken_GB
dc.contributor.authorLoane, Mariaen_GB
dc.contributor.authorGarne, Esteren_GB
dc.contributor.authorAddor, Marie-Claudeen_GB
dc.contributor.authorArriola, Larraitzen_GB
dc.contributor.authorBakker, Marianen_GB
dc.contributor.authorBarisic, Ingeborgen_GB
dc.contributor.authorBianca, Sebastianoen_GB
dc.contributor.authorBoyd, Patriciaen_GB
dc.contributor.authorCalzolari, Elisaen_GB
dc.contributor.authorDoray, Bereniceen_GB
dc.contributor.authorDraper, Elizabethen_GB
dc.contributor.authorGatt, Miriamen_GB
dc.contributor.authorHaeusler, Martinen_GB
dc.contributor.authorMelve, Kari Klungsoyren_GB
dc.contributor.authorLatos-Bielenska, Annaen_GB
dc.contributor.authorMcDonnell, Boben_GB
dc.contributor.authorMullaney, Carmelen_GB
dc.contributor.authorNelen, Veraen_GB
dc.contributor.authorO'Mahony, Maryen_GB
dc.contributor.authorPierini, Annaen_GB
dc.contributor.authorQueisser-Luft, Annetteen_GB
dc.contributor.authorRandrianaivo, Hanitraen_GB
dc.contributor.authorRankin, Judithen_GB
dc.contributor.authorRissmann, Ankeen_GB
dc.contributor.authorSalvador, Joaquinen_GB
dc.contributor.authorTucker, Daviden_GB
dc.contributor.authorVerellen-Dumoulin, Christineen_GB
dc.contributor.authorWellesley, Dianaen_GB
dc.contributor.authorZymak-Zakutnya, Natalyaen_GB
dc.contributor.authorDolk, Helenen_GB
dc.date.accessioned2014-07-18T12:02:00Z-
dc.date.available2014-07-18T12:02:00Z-
dc.date.issued2014-07-18-
dc.identifier.citationKhoshnood B et al. Recent decrease in the prevalence of congenital heart defects in Europe. J Ped 2013, 162 (1):108en_GB
dc.identifier.issn00223476-
dc.identifier.doi10.1016/j.jpeds.2012.06.035-
dc.identifier.urihttp://hdl.handle.net/10147/323407-
dc.descriptionOBJECTIVES: To examine trends in the prevalence of congenital heart defects (CHDs) in Europe and to compare these trends with the recent decrease in the prevalence of CHDs in Canada (Quebec) that was attributed to the policy of mandatory folic acid fortification. STUDY DESIGN: We used data for the period 1990-2007 for 47 508 cases of CHD not associated with a chromosomal anomaly from 29 population-based European Surveillance of Congenital Anomalies registries in 16 countries covering 7.3 million births. We estimated trends for all CHDs combined and separately for 3 severity groups using random-effects Poisson regression models with splines. RESULTS: We found that the total prevalence of CHDs increased during the 1990s and the early 2000s until 2004 and decreased thereafter. We found essentially no trend in total prevalence of the most severe group (group I), whereas the prevalence of severity group II increased until about 2000 and decreased thereafter. Trends for severity group III (the most prevalent group) paralleled those for all CHDs combined. CONCLUSIONS: The prevalence of CHDs decreased in recent years in Europe in the absence of a policy for mandatory folic acid fortification. One possible explanation for this decrease may be an as-yet-undocumented increase in folic acid intake of women in Europe following recommendations for folic acid supplementation and/or voluntary fortification. However, alternative hypotheses, including reductions in risk factors of CHDs (eg, maternal smoking) and improved management of maternal chronic health conditions (eg, diabetes), must also be considered for explaining the observed decrease in the prevalence of CHDs in Europe or elsewhere. Copyright © 2013 Mosby, Inc. All rights reserved.en_GB
dc.language.isoenen
dc.relation.urlhttp://linkinghub.elsevier.com/retrieve/pii/S0022347612006762en_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/22835879en_GB
dc.rightsArchived with thanks to The Journal of Pediatricsen_GB
dc.subjectCHILD HEALTHen_GB
dc.subject.otherHEART DEFECTS, CONGENITALen_GB
dc.titleRecent decrease in the prevalence of congenital heart defects in Europeen_GB
dc.typeArticleen
dc.identifier.journalJournal of pediatricsen_GB
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