Trends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly: a registry-based study in 14 European countries 1984-2007

Hdl Handle:
http://hdl.handle.net/10147/323379
Title:
Trends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly: a registry-based study in 14 European countries 1984-2007
Authors:
Boyle, B; McConkey, R; Garne, E; Loane, M; Addor, MC; Bakker, MK; Boyd, PA; Gatt, M; Greenlees, R; Haeusler, M; Klungsøyr, K; Latos-Bielenska, A; Lelong, N; McDonnell, R; Métneki, J; Mullaney, C; Nelen, V; O'Mahony, M; Pierini, A; Rankin, J; Rissmann, A; Tucker, D; Wellesley, D; Dolk, H
Citation:
Boyle B et al. Trends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly: a registry-based study in 14 European countries 1984-2007. BJOG: An International Journal of Obstetrics & Gynaecology 2013, 120 (6):707
Journal:
BJOG: An International Journal of Obstetrics & Gynaecology
Issue Date:
18-Jul-2014
URI:
http://hdl.handle.net/10147/323379
DOI:
10.1111/1471-0528.12146
Additional Links:
http://doi.wiley.com/10.1111/1471-0528.12146
Item Type:
Article
Language:
en
Description:
To assess the public health consequences of the rise in multiple births with respect to congenital anomalies. DESIGN: Descriptive epidemiological analysis of data from population-based congenital anomaly registries. SETTING: Fourteen European countries. POPULATION: A total of 5.4 million births 1984-2007, of which 3% were multiple births. METHODS: Cases of congenital anomaly included live births, fetal deaths from 20 weeks of gestation and terminations of pregnancy for fetal anomaly. MAIN OUTCOME MEASURES: Prevalence rates per 10,000 births and relative risk of congenital anomaly in multiple versus singleton births (1984-2007); proportion prenatally diagnosed, proportion by pregnancy outcome (2000-07). Proportion of pairs where both co-twins were cases. RESULTS: Prevalence of congenital anomalies from multiple births increased from 5.9 (1984-87) to 10.7 per 10,000 births (2004-07). Relative risk of nonchromosomal anomaly in multiple births was 1.35 (95% CI 1.31-1.39), increasing over time, and of chromosomal anomalies was 0.72 (95% CI 0.65-0.80), decreasing over time. In 11.4% of affected twin pairs both babies had congenital anomalies (2000-07). The prenatal diagnosis rate was similar for multiple and singleton pregnancies. Cases from multiple pregnancies were less likely to be terminations of pregnancy for fetal anomaly, odds ratio 0.41 (95% CI 0.35-0.48) and more likely to be stillbirths and neonatal deaths. CONCLUSIONS: The increase in babies who are both from a multiple pregnancy and affected by a congenital anomaly has implications for prenatal and postnatal service provision. The contribution of assisted reproductive technologies to the increase in risk needs further research. The deficit of chromosomal anomalies among multiple births has relevance for prenatal risk counselling. © 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.
Keywords:
PREGNANCY; CHILDBIRTH; RISK ASSESSMENT
Local subject classification:
PUBLIC HEALTH DEPARTMENT; CONGENITAL ANOMALY; HEALTH IMPROVEMENT
ISSN:
14700328

Full metadata record

DC FieldValue Language
dc.contributor.authorBoyle, Ben_GB
dc.contributor.authorMcConkey, Ren_GB
dc.contributor.authorGarne, Een_GB
dc.contributor.authorLoane, Men_GB
dc.contributor.authorAddor, MCen_GB
dc.contributor.authorBakker, MKen_GB
dc.contributor.authorBoyd, PAen_GB
dc.contributor.authorGatt, Men_GB
dc.contributor.authorGreenlees, Ren_GB
dc.contributor.authorHaeusler, Men_GB
dc.contributor.authorKlungsøyr, Ken_GB
dc.contributor.authorLatos-Bielenska, Aen_GB
dc.contributor.authorLelong, Nen_GB
dc.contributor.authorMcDonnell, Ren_GB
dc.contributor.authorMétneki, Jen_GB
dc.contributor.authorMullaney, Cen_GB
dc.contributor.authorNelen, Ven_GB
dc.contributor.authorO'Mahony, Men_GB
dc.contributor.authorPierini, Aen_GB
dc.contributor.authorRankin, Jen_GB
dc.contributor.authorRissmann, Aen_GB
dc.contributor.authorTucker, Den_GB
dc.contributor.authorWellesley, Den_GB
dc.contributor.authorDolk, Hen_GB
dc.date.accessioned2014-07-18T10:38:18Zen
dc.date.available2014-07-18T10:38:18Zen
dc.date.issued2014-07-18en
dc.identifier.citationBoyle B et al. Trends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly: a registry-based study in 14 European countries 1984-2007. BJOG: An International Journal of Obstetrics & Gynaecology 2013, 120 (6):707en_GB
dc.identifier.issn14700328en
dc.identifier.doi10.1111/1471-0528.12146en
dc.identifier.urihttp://hdl.handle.net/10147/323379en
dc.descriptionTo assess the public health consequences of the rise in multiple births with respect to congenital anomalies. DESIGN: Descriptive epidemiological analysis of data from population-based congenital anomaly registries. SETTING: Fourteen European countries. POPULATION: A total of 5.4 million births 1984-2007, of which 3% were multiple births. METHODS: Cases of congenital anomaly included live births, fetal deaths from 20 weeks of gestation and terminations of pregnancy for fetal anomaly. MAIN OUTCOME MEASURES: Prevalence rates per 10,000 births and relative risk of congenital anomaly in multiple versus singleton births (1984-2007); proportion prenatally diagnosed, proportion by pregnancy outcome (2000-07). Proportion of pairs where both co-twins were cases. RESULTS: Prevalence of congenital anomalies from multiple births increased from 5.9 (1984-87) to 10.7 per 10,000 births (2004-07). Relative risk of nonchromosomal anomaly in multiple births was 1.35 (95% CI 1.31-1.39), increasing over time, and of chromosomal anomalies was 0.72 (95% CI 0.65-0.80), decreasing over time. In 11.4% of affected twin pairs both babies had congenital anomalies (2000-07). The prenatal diagnosis rate was similar for multiple and singleton pregnancies. Cases from multiple pregnancies were less likely to be terminations of pregnancy for fetal anomaly, odds ratio 0.41 (95% CI 0.35-0.48) and more likely to be stillbirths and neonatal deaths. CONCLUSIONS: The increase in babies who are both from a multiple pregnancy and affected by a congenital anomaly has implications for prenatal and postnatal service provision. The contribution of assisted reproductive technologies to the increase in risk needs further research. The deficit of chromosomal anomalies among multiple births has relevance for prenatal risk counselling. © 2013 The Authors BJOG An International Journal of Obstetrics and Gynaecology © 2013 RCOG.en_GB
dc.language.isoenen
dc.relation.urlhttp://doi.wiley.com/10.1111/1471-0528.12146en_GB
dc.rightsArchived with thanks to BJOG: An International Journal of Obstetrics & Gynaecologyen_GB
dc.subjectPREGNANCYen_GB
dc.subjectCHILDBIRTHen_GB
dc.subjectRISK ASSESSMENTen_GB
dc.subject.otherPUBLIC HEALTH DEPARTMENTen
dc.subject.otherCONGENITAL ANOMALYen
dc.subject.otherHEALTH IMPROVEMENTen
dc.titleTrends in the prevalence, risk and pregnancy outcome of multiple births with congenital anomaly: a registry-based study in 14 European countries 1984-2007en_GB
dc.typeArticleen
dc.identifier.journalBJOG: An International Journal of Obstetrics & Gynaecologyen_GB
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