DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells.

Hdl Handle:
http://hdl.handle.net/10147/323264
Title:
DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells.
Authors:
Martin, Lynn M; Marples, Brian; Davies, Anthony M; Atzberger, Ann; Edwards, Connla; Lynch, Thomas H; Hollywood, Donal; Marignol, Laure
Affiliation:
Radiation and Urologic Oncology, Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, Trinity College Dublin, Dublin 8, Ireland.
Citation:
Martin LM et al. DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells. 2013, 335 (1):19-25 Cancer Lett.
Publisher:
Elsevier Ireland Ltd
Journal:
Cancer letters
Issue Date:
10-Jul-2013
URI:
http://hdl.handle.net/10147/323264
DOI:
10.1016/j.canlet.2013.01.046
PubMed ID:
23376256
Abstract:
DNA repair and G2-phase cell cycle checkpoint responses are involved in the manifestation of hyper-radiosensitivity (HRS). The low-dose radioresponse of MSH2 isogenic endometrial carcinoma cell lines was examined. Defects in cell cycle checkpoint activation and the DNA damage response in irradiated cells (0.2 Gy) were evaluated. HRS was expressed solely in MSH2+ cells and was associated with efficient activation of the early G2-phase cell cycle checkpoint. Maintenance of the arrest was associated with persistent MRE11, γH2AX, RAD51 foci at 2 h after irradiation. Persistent MRE11 and RAD51 foci were also evident 24 h after 0.2 Gy. MSH2 significantly enhances cell radiosensitivity to low dose IR.
Item Type:
Article
Language:
en
Keywords:
CANCER
Local subject classification:
CELL BIOLOGY
MeSH:
Carcinoma; Cell Line, Tumor; Cell Nucleus; Cell Survival; DNA Mismatch Repair; DNA-Binding Proteins; Endometrial Neoplasms; Female; G2 Phase Cell Cycle Checkpoints; Gene Expression; Histones; Humans; MutS Homolog 2 Protein; Radiation Tolerance; Recombinational DNA Repair
ISSN:
1872-7980

Full metadata record

DC FieldValue Language
dc.contributor.authorMartin, Lynn Men_GB
dc.contributor.authorMarples, Brianen_GB
dc.contributor.authorDavies, Anthony Men_GB
dc.contributor.authorAtzberger, Annen_GB
dc.contributor.authorEdwards, Connlaen_GB
dc.contributor.authorLynch, Thomas Hen_GB
dc.contributor.authorHollywood, Donalen_GB
dc.contributor.authorMarignol, Laureen_GB
dc.date.accessioned2014-07-17T09:31:59Z-
dc.date.available2014-07-17T09:31:59Z-
dc.date.issued2013-07-10-
dc.identifier.citationMartin LM et al. DNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells. 2013, 335 (1):19-25 Cancer Lett.en_GB
dc.identifier.issn1872-7980-
dc.identifier.pmid23376256-
dc.identifier.doi10.1016/j.canlet.2013.01.046-
dc.identifier.urihttp://hdl.handle.net/10147/323264-
dc.description.abstractDNA repair and G2-phase cell cycle checkpoint responses are involved in the manifestation of hyper-radiosensitivity (HRS). The low-dose radioresponse of MSH2 isogenic endometrial carcinoma cell lines was examined. Defects in cell cycle checkpoint activation and the DNA damage response in irradiated cells (0.2 Gy) were evaluated. HRS was expressed solely in MSH2+ cells and was associated with efficient activation of the early G2-phase cell cycle checkpoint. Maintenance of the arrest was associated with persistent MRE11, γH2AX, RAD51 foci at 2 h after irradiation. Persistent MRE11 and RAD51 foci were also evident 24 h after 0.2 Gy. MSH2 significantly enhances cell radiosensitivity to low dose IR.en_GB
dc.language.isoenen
dc.publisherElsevier Ireland Ltden_GB
dc.rightsArchived with thanks to Cancer lettersen_GB
dc.subjectCANCERen_GB
dc.subject.meshCarcinoma-
dc.subject.meshCell Line, Tumor-
dc.subject.meshCell Nucleus-
dc.subject.meshCell Survival-
dc.subject.meshDNA Mismatch Repair-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshEndometrial Neoplasms-
dc.subject.meshFemale-
dc.subject.meshG2 Phase Cell Cycle Checkpoints-
dc.subject.meshGene Expression-
dc.subject.meshHistones-
dc.subject.meshHumans-
dc.subject.meshMutS Homolog 2 Protein-
dc.subject.meshRadiation Tolerance-
dc.subject.meshRecombinational DNA Repair-
dc.subject.otherCELL BIOLOGYen_GB
dc.titleDNA mismatch repair protein MSH2 dictates cellular survival in response to low dose radiation in endometrial carcinoma cells.en_GB
dc.typeArticleen
dc.contributor.departmentRadiation and Urologic Oncology, Prostate Molecular Oncology Research Group, Academic Unit of Clinical and Molecular Oncology, Institute of Molecular Medicine, Trinity College Dublin, Dublin 8, Ireland.en_GB
dc.identifier.journalCancer lettersen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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