Serum lipids associated with inflammation-related PET-FDG uptake in symptomatic carotid plaque

Hdl Handle:
http://hdl.handle.net/10147/321764
Title:
Serum lipids associated with inflammation-related PET-FDG uptake in symptomatic carotid plaque
Authors:
Chroinin, D. N.; Marnane, M.; Akijian, L.; Merwick, A.; Fallon, E.; Horgan, G.; Dolan, E.; Murphy, S.; O'Rourke, K.; O'Malley, K.; O'Donohoe, M.; McDonnell, C.; Noone, I.; Barry, M.; Crowe, M.; Kavanagh, E.; O'Connell, M.; Kelly, P. J.
Citation:
Chroinin DN et al. Serum lipids associated with inflammation-related PET-FDG uptake in symptomatic carotid plaque. Neurology. 2014, 82 (19):1693
Publisher:
Neurology
Journal:
Neurology
Issue Date:
Apr-2014
URI:
http://hdl.handle.net/10147/321764
DOI:
10.1212/WNL.0000000000000408
Additional Links:
http://www.neurology.org/cgi/doi/10.1212/WNL.0000000000000408
Item Type:
Article
Language:
en
Description:
Objective: We hypothesized that serum lipids, which experimental data suggest may be key initiators of carotid plaque inflammation, would be associated with plaque inflammation on 18fluorodeoxyglucose (FDG)-PET in patients with acutely symptomatic carotid stenosis. Methods: In this cohort study, consecutive patients with acute symptomatic internal carotid artery (ICA) stenosis (≥50%) underwent carotid PET-CT. We quantified plaque FDG uptake as follows: (1) average maximum standardized uptake values (SUVmax) across 10 regions of interest (ROI); (2) highest single ROI SUV measure (SUVROImax); (3) averaged mean SUV across 10 ROIs (SUVmean). Results: Sixty-one patients were included. Plaque inflammatory FDG SUVmax was associated with increasing tertiles of low-density lipoprotein (LDL) (trend p = 0.004), total cholesterol (p = 0.009), and triglycerides (p = 0.01), and with lower high-density lipoprotein (HDL) (p = 0.005). When analyzed as a continuous variable, LDL was associated with symptomatic ICA SUVmean (Spearman rho 0.44, p = 0.009), SUVROImax (rho 0.33, p = 0.01), and SUVmax (rho 0.35, p = 0.06). Total cholesterol was associated with SUVmean (rho 0.33, p = 0.009), with trends for SUVmax (rho 0.24, p = 0.059) and SUVROImax (rho 0.23, p = 0.08). Triglycerides were associated with SUVmax (rho 0.32, p = 0.01) and SUVROImax (rho 0.35, p = 0.005). HDL was associated with lower SUVmax (rho −0.37, p = 0.004) and SUVROImax (rho −0.44, p = 0.0004). On multivariable linear regression analysis adjusting for age, sex, degree of carotid stenosis, statins, and smoking, LDL (p = 0.008) and total cholesterol (p = 0.04) were independently associated with SUVmax. Conclusion: Serum LDL and total cholesterol were associated with acutely symptomatic carotid plaque FDG uptake, supporting experimental data suggesting lipids may promote plaque inflammation, mediating rupture and clinical events.
Keywords:
CARDIOVASCULAR DISEASE
ISSN:
0028-3878; 1526-632X

Full metadata record

DC FieldValue Language
dc.contributor.authorChroinin, D. N.en_GB
dc.contributor.authorMarnane, M.en_GB
dc.contributor.authorAkijian, L.en_GB
dc.contributor.authorMerwick, A.en_GB
dc.contributor.authorFallon, E.en_GB
dc.contributor.authorHorgan, G.en_GB
dc.contributor.authorDolan, E.en_GB
dc.contributor.authorMurphy, S.en_GB
dc.contributor.authorO'Rourke, K.en_GB
dc.contributor.authorO'Malley, K.en_GB
dc.contributor.authorO'Donohoe, M.en_GB
dc.contributor.authorMcDonnell, C.en_GB
dc.contributor.authorNoone, I.en_GB
dc.contributor.authorBarry, M.en_GB
dc.contributor.authorCrowe, M.en_GB
dc.contributor.authorKavanagh, E.en_GB
dc.contributor.authorO'Connell, M.en_GB
dc.contributor.authorKelly, P. J.en_GB
dc.date.accessioned2014-06-17T15:30:07Z-
dc.date.available2014-06-17T15:30:07Z-
dc.date.issued2014-04-
dc.identifier.citationChroinin DN et al. Serum lipids associated with inflammation-related PET-FDG uptake in symptomatic carotid plaque. Neurology. 2014, 82 (19):1693en_GB
dc.identifier.issn0028-3878-
dc.identifier.issn1526-632X-
dc.identifier.doi10.1212/WNL.0000000000000408-
dc.identifier.urihttp://hdl.handle.net/10147/321764-
dc.descriptionObjective: We hypothesized that serum lipids, which experimental data suggest may be key initiators of carotid plaque inflammation, would be associated with plaque inflammation on 18fluorodeoxyglucose (FDG)-PET in patients with acutely symptomatic carotid stenosis. Methods: In this cohort study, consecutive patients with acute symptomatic internal carotid artery (ICA) stenosis (≥50%) underwent carotid PET-CT. We quantified plaque FDG uptake as follows: (1) average maximum standardized uptake values (SUVmax) across 10 regions of interest (ROI); (2) highest single ROI SUV measure (SUVROImax); (3) averaged mean SUV across 10 ROIs (SUVmean). Results: Sixty-one patients were included. Plaque inflammatory FDG SUVmax was associated with increasing tertiles of low-density lipoprotein (LDL) (trend p = 0.004), total cholesterol (p = 0.009), and triglycerides (p = 0.01), and with lower high-density lipoprotein (HDL) (p = 0.005). When analyzed as a continuous variable, LDL was associated with symptomatic ICA SUVmean (Spearman rho 0.44, p = 0.009), SUVROImax (rho 0.33, p = 0.01), and SUVmax (rho 0.35, p = 0.06). Total cholesterol was associated with SUVmean (rho 0.33, p = 0.009), with trends for SUVmax (rho 0.24, p = 0.059) and SUVROImax (rho 0.23, p = 0.08). Triglycerides were associated with SUVmax (rho 0.32, p = 0.01) and SUVROImax (rho 0.35, p = 0.005). HDL was associated with lower SUVmax (rho −0.37, p = 0.004) and SUVROImax (rho −0.44, p = 0.0004). On multivariable linear regression analysis adjusting for age, sex, degree of carotid stenosis, statins, and smoking, LDL (p = 0.008) and total cholesterol (p = 0.04) were independently associated with SUVmax. Conclusion: Serum LDL and total cholesterol were associated with acutely symptomatic carotid plaque FDG uptake, supporting experimental data suggesting lipids may promote plaque inflammation, mediating rupture and clinical events.en_GB
dc.language.isoenen
dc.publisherNeurologyen_GB
dc.relation.urlhttp://www.neurology.org/cgi/doi/10.1212/WNL.0000000000000408en_GB
dc.rightsArchived with thanks to Neurologyen_GB
dc.subjectCARDIOVASCULAR DISEASEen_GB
dc.titleSerum lipids associated with inflammation-related PET-FDG uptake in symptomatic carotid plaqueen_GB
dc.typeArticleen
dc.identifier.journalNeurologyen_GB
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