Pulmonary blastoma: a case report and review of the literature

Hdl Handle:
http://hdl.handle.net/10147/317210
Title:
Pulmonary blastoma: a case report and review of the literature
Authors:
Smyth, Robert J; Fabre, Aurelie; Dodd, Johnathan D; Bartosik, Waldemar; Gallagher, Charles G; McKone, Edward F
Citation:
BMC Research Notes. 2014 May 13;7(1):294
Issue Date:
13-May-2014
URI:
http://dx.doi.org/10.1186/1756-0500-7-294; http://hdl.handle.net/10147/317210
Abstract:
Abstract Background Pulmonary blastomas are a rare aggressive neoplasm comprising 0.25-0.5% of all primary lung tumors and portend a poor prognosis. They display a biphasic histology with mesenchymal and epithelial components. Historically, the term pulmonary blastoma had included both pure fetal adenocarcinomas, pleuropulmonary blastomas as well as the classic biphasic blastomas. However recent World Health Organisation re-classifications separated well-differentiated fetal adenocarcinomas and pleuropulmonary blastomas from the biphasic tumours. Case presentation We present a case of a systemically well 67-year-old Caucasian male who presented with haemoptysis. Investigations confirmed the presence of a large right-sided lung mass and biopsy identified non-small cell carcinoma. The resected tumour was markedly necrotic revealing a biphasic pattern. It was composed of malignant glandular tissue with sub-nuclear vacuoles, associated with a pleomorphic stromal malignant blastematous component, characteristic of classic biphasic pulmonary blastoma. Conclusion We present a case of a classic biphasic pulmonary blastoma, a rare lung cancer occurring at an earlier age and portending to poorer prognosis than other more common lung cancers. Given the small number of cases and recent re-classification, interpreting the published epidemiology and clinical features of this disease is difficult. Many earlier reports may have included fetal adenocarcinomas (in particular high grade variant), which need to be considered when discussing treatment and prognosis with newly-diagnosed patients. Much could be gained from a central registry of individual experiences to improve our understanding of this rare lung cancer.
Item Type:
Article
Language:
en
Local subject classification:
PULMONARY BLASTOMA

Full metadata record

DC FieldValue Language
dc.contributor.authorSmyth, Robert Jen_GB
dc.contributor.authorFabre, Aurelieen_GB
dc.contributor.authorDodd, Johnathan Den_GB
dc.contributor.authorBartosik, Waldemaren_GB
dc.contributor.authorGallagher, Charles Gen_GB
dc.contributor.authorMcKone, Edward Fen_GB
dc.date.accessioned2014-05-20T11:23:05Z-
dc.date.available2014-05-20T11:23:05Z-
dc.date.issued2014-05-13-
dc.identifier.citationBMC Research Notes. 2014 May 13;7(1):294en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1756-0500-7-294-
dc.identifier.urihttp://hdl.handle.net/10147/317210-
dc.description.abstractAbstract Background Pulmonary blastomas are a rare aggressive neoplasm comprising 0.25-0.5% of all primary lung tumors and portend a poor prognosis. They display a biphasic histology with mesenchymal and epithelial components. Historically, the term pulmonary blastoma had included both pure fetal adenocarcinomas, pleuropulmonary blastomas as well as the classic biphasic blastomas. However recent World Health Organisation re-classifications separated well-differentiated fetal adenocarcinomas and pleuropulmonary blastomas from the biphasic tumours. Case presentation We present a case of a systemically well 67-year-old Caucasian male who presented with haemoptysis. Investigations confirmed the presence of a large right-sided lung mass and biopsy identified non-small cell carcinoma. The resected tumour was markedly necrotic revealing a biphasic pattern. It was composed of malignant glandular tissue with sub-nuclear vacuoles, associated with a pleomorphic stromal malignant blastematous component, characteristic of classic biphasic pulmonary blastoma. Conclusion We present a case of a classic biphasic pulmonary blastoma, a rare lung cancer occurring at an earlier age and portending to poorer prognosis than other more common lung cancers. Given the small number of cases and recent re-classification, interpreting the published epidemiology and clinical features of this disease is difficult. Many earlier reports may have included fetal adenocarcinomas (in particular high grade variant), which need to be considered when discussing treatment and prognosis with newly-diagnosed patients. Much could be gained from a central registry of individual experiences to improve our understanding of this rare lung cancer.-
dc.language.isoenen
dc.subject.otherPULMONARY BLASTOMAen_GB
dc.titlePulmonary blastoma: a case report and review of the literatureen_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderRobert J Smyth et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2014-05-20T07:12:12Z-
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