Long-term risk of stroke after transient ischaemic attack: a hospital-based validation of the ABCD2 rule

Hdl Handle:
http://hdl.handle.net/10147/316754
Title:
Long-term risk of stroke after transient ischaemic attack: a hospital-based validation of the ABCD2 rule
Authors:
Galvin, Rose; Atanassova, Penka A; Motterlini, Nicola; Fahey, Tom; Dimitrov, Borislav D
Citation:
Galvin R et al. Long-term risk of stroke after transient ischaemic attack: a hospital-based validation of the ABCD2 ruleBMC Research Notes. 2014 May 04;7(1):281
Journal:
BMC research notes
Issue Date:
4-May-2014
URI:
http://dx.doi.org/10.1186/1756-0500-7-281; http://hdl.handle.net/10147/316754
Abstract:
Abstract Background The ABCD2 clinical prediction rule is a seven point summation of clinical factors independently predictive of stroke risk. The purpose of this cohort study is to validate the ABCD2 rule in a Bulgarian hospital up to three years after TIA. Methods All consecutive admissions to an emergency department with symptoms of a first TIA were included. Baseline data and clinical examinations including the ABCD2 scores were documented by neurologists. Discrimination and calibration performance was examined using ABCD2 cut-off scores of ≥3, ≥4 and ≥5 points, consistent with the international guidelines. The Hosmer-Lemeshow test was used to examine calibration between the observed and expected outcomes as predicted by ABCD2 score within the logistic regression analysis. Results Eighty-nine patients were enrolled to the study with a mean age of 63 years (+/- 12 years). Fifty-nine percent (n = 53) of the study population was male. Seven strokes (7 · 8%) occurred within the first year and six further strokes within the three-year follow-up period. There was no incident of stroke within the first 90 days after TIA. The rule demonstrated good predictive (OR = 1 · 58, 95% CI 1 · 09-2 · 29) and discriminative performance (AUCROC = 0 · 72, 95% CI 0 · 58-0 · 86), as well as a moderate calibration performance at three years. Conclusion This validation of the ABCD2 rule in a Bulgarian hospital demonstrates that the rule has good predictive and discriminative performance at three years. The ABCD2 is quick to administer and may serve as a useful tool to assist clinicians in the long-term management of individuals with TIA.
Item Type:
Article
Language:
en
Keywords:
STROKE AND TIA

Full metadata record

DC FieldValue Language
dc.contributor.authorGalvin, Roseen_GB
dc.contributor.authorAtanassova, Penka Aen_GB
dc.contributor.authorMotterlini, Nicolaen_GB
dc.contributor.authorFahey, Tomen_GB
dc.contributor.authorDimitrov, Borislav Den_GB
dc.date.accessioned2014-05-13T12:15:35Z-
dc.date.available2014-05-13T12:15:35Z-
dc.date.issued2014-05-04-
dc.identifier.citationGalvin R et al. Long-term risk of stroke after transient ischaemic attack: a hospital-based validation of the ABCD2 ruleBMC Research Notes. 2014 May 04;7(1):281en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1756-0500-7-281-
dc.identifier.urihttp://hdl.handle.net/10147/316754-
dc.description.abstractAbstract Background The ABCD2 clinical prediction rule is a seven point summation of clinical factors independently predictive of stroke risk. The purpose of this cohort study is to validate the ABCD2 rule in a Bulgarian hospital up to three years after TIA. Methods All consecutive admissions to an emergency department with symptoms of a first TIA were included. Baseline data and clinical examinations including the ABCD2 scores were documented by neurologists. Discrimination and calibration performance was examined using ABCD2 cut-off scores of ≥3, ≥4 and ≥5 points, consistent with the international guidelines. The Hosmer-Lemeshow test was used to examine calibration between the observed and expected outcomes as predicted by ABCD2 score within the logistic regression analysis. Results Eighty-nine patients were enrolled to the study with a mean age of 63 years (+/- 12 years). Fifty-nine percent (n = 53) of the study population was male. Seven strokes (7 · 8%) occurred within the first year and six further strokes within the three-year follow-up period. There was no incident of stroke within the first 90 days after TIA. The rule demonstrated good predictive (OR = 1 · 58, 95% CI 1 · 09-2 · 29) and discriminative performance (AUCROC = 0 · 72, 95% CI 0 · 58-0 · 86), as well as a moderate calibration performance at three years. Conclusion This validation of the ABCD2 rule in a Bulgarian hospital demonstrates that the rule has good predictive and discriminative performance at three years. The ABCD2 is quick to administer and may serve as a useful tool to assist clinicians in the long-term management of individuals with TIA.-
dc.language.isoenen
dc.subjectSTROKE AND TIAen_GB
dc.titleLong-term risk of stroke after transient ischaemic attack: a hospital-based validation of the ABCD2 ruleen_GB
dc.typeArticleen
dc.identifier.journalBMC research notesen_GB
dc.language.rfc3066en-
dc.rights.holderRose Galvin et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2014-05-08T07:05:56Z-
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