The prevalence of psychosis in epilepsy; a systematic review and meta-analysis

Hdl Handle:
http://hdl.handle.net/10147/316013
Title:
The prevalence of psychosis in epilepsy; a systematic review and meta-analysis
Authors:
Clancy, Maurice J; Clarke, Mary C; Connor, Dearbhla J; Cannon, Mary; Cotter, David R
Citation:
BMC Psychiatry. 2014 Mar 13;14(1):75
Journal:
BMC psychiatry
Issue Date:
13-Mar-2014
URI:
http://dx.doi.org/10.1186/1471-244X-14-75; http://hdl.handle.net/10147/316013
Abstract:
Abstract Background Epilepsy has long been considered to be a risk factor for psychosis. However there is a lack of consistency in findings across studies on the effect size of this risk which reflects methodological differences in studies and changing diagnostic classifications within neurology and psychiatry. The aim of this study was to assess the prevalence of psychosis in epilepsy and to estimate the risk of psychosis among individuals with epilepsy compared with controls. Methods A systematic review and meta-analysis was conducted of all published literature pertaining to prevalence rates of psychosis in epilepsy using electronic databases PUBMED, OVIDMEDLINE, PsychINFO and Embase from their inception until September 2010 with the following search terms: prevalence, incidence, rate, rates, psychosis, schizophrenia, schizophreniform illness, epilepsy, seizures, temporal lobe epilepsy. Results The literature search and search of reference lists yielded 215 papers. Of these, 58 (27%) had data relevant to the review and 157 were excluded following a more detailed assessment. 10% of the included studies were population based studies. The pooled odds ratio for risk of psychosis among people with epilepsy compared with controls was 7.8. The pooled estimate of prevalence of psychosis in epilepsy was found to be 5.6% (95% CI: 4.8-6.4). There was a high level of heterogeneity. The prevalence of psychosis in temporal lobe epilepsy was 7% (95% CI: 4.9-9.1). The prevalence of interictal psychosis in epilepsy was 5.2% (95% CI: 3.3-7.2). The prevalence of postictal psychosis in epilepsy was 2% (95% CI: 1.2-2.8). Conclusions Our systematic review found that up to 6% of individuals with epilepsy have a co-morbid psychotic illness and that patients have an almost eight fold increased risk of psychosis. The prevalence rate of psychosis is higher in temporal lobe epilepsy (7%). We suggest that further investigation of this association could give clues to the aetiology of psychosis.
Item Type:
Article
Language:
en
Keywords:
EPILEPSY; MENTAL AND BEHAVIOURAL DISORDER

Full metadata record

DC FieldValue Language
dc.contributor.authorClancy, Maurice Jen_GB
dc.contributor.authorClarke, Mary Cen_GB
dc.contributor.authorConnor, Dearbhla Jen_GB
dc.contributor.authorCannon, Maryen_GB
dc.contributor.authorCotter, David Ren_GB
dc.date.accessioned2014-04-22T11:08:51Z-
dc.date.available2014-04-22T11:08:51Z-
dc.date.issued2014-03-13-
dc.identifier.citationBMC Psychiatry. 2014 Mar 13;14(1):75en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1471-244X-14-75-
dc.identifier.urihttp://hdl.handle.net/10147/316013-
dc.description.abstractAbstract Background Epilepsy has long been considered to be a risk factor for psychosis. However there is a lack of consistency in findings across studies on the effect size of this risk which reflects methodological differences in studies and changing diagnostic classifications within neurology and psychiatry. The aim of this study was to assess the prevalence of psychosis in epilepsy and to estimate the risk of psychosis among individuals with epilepsy compared with controls. Methods A systematic review and meta-analysis was conducted of all published literature pertaining to prevalence rates of psychosis in epilepsy using electronic databases PUBMED, OVIDMEDLINE, PsychINFO and Embase from their inception until September 2010 with the following search terms: prevalence, incidence, rate, rates, psychosis, schizophrenia, schizophreniform illness, epilepsy, seizures, temporal lobe epilepsy. Results The literature search and search of reference lists yielded 215 papers. Of these, 58 (27%) had data relevant to the review and 157 were excluded following a more detailed assessment. 10% of the included studies were population based studies. The pooled odds ratio for risk of psychosis among people with epilepsy compared with controls was 7.8. The pooled estimate of prevalence of psychosis in epilepsy was found to be 5.6% (95% CI: 4.8-6.4). There was a high level of heterogeneity. The prevalence of psychosis in temporal lobe epilepsy was 7% (95% CI: 4.9-9.1). The prevalence of interictal psychosis in epilepsy was 5.2% (95% CI: 3.3-7.2). The prevalence of postictal psychosis in epilepsy was 2% (95% CI: 1.2-2.8). Conclusions Our systematic review found that up to 6% of individuals with epilepsy have a co-morbid psychotic illness and that patients have an almost eight fold increased risk of psychosis. The prevalence rate of psychosis is higher in temporal lobe epilepsy (7%). We suggest that further investigation of this association could give clues to the aetiology of psychosis.-
dc.language.isoenen
dc.subjectEPILEPSYen_GB
dc.subjectMENTAL AND BEHAVIOURAL DISORDERen_GB
dc.titleThe prevalence of psychosis in epilepsy; a systematic review and meta-analysisen_GB
dc.typeArticleen
dc.identifier.journalBMC psychiatryen_GB
dc.language.rfc3066en-
dc.rights.holderMaurice J Clancy et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2014-04-20T07:18:41Z-
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