The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth.

Hdl Handle:
http://hdl.handle.net/10147/315564
Title:
The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth.
Authors:
Walsh, Jennifer M; McGowan, Ciara A; Kilbane, Mark; McKenna, Malachi J; McAuliffe, Fionnuala M
Affiliation:
UCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Ireland
Citation:
The relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth. 2013, 20 (5):536-41 Reprod Sci
Journal:
Reproductive sciences (Thousand Oaks, Calif.)
Issue Date:
May-2013
URI:
http://hdl.handle.net/10147/315564
DOI:
10.1177/1933719112459222
PubMed ID:
22968764
Additional Links:
http://rsx.sagepub.com/content/20/5/536.long
Abstract:
Evidence for a role of vitamin D in maintaining normal glucose homeostasis is inconclusive. We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status. This is a prospective cohort study of 60 caucasian pregnant women. Concentrations of 25-hydroxyvitamin D (25-OHD), glucose, insulin, and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width, a marker of fetal adiposity. At delivery birth weight was recorded and fetal 25-OHD, glucose, C-peptide, and leptin measured in cord blood. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. We found that those with lower 25-OHD in early pregnancy had higher HOMA indices at 28 weeks, (r = -.32, P = .02). No significant relationship existed between maternal or fetal leptin and 25-OHD, or between maternal or fetal 25-OHD and fetal anthropometry or birth weight. The incidence of vitamin D deficiency was high at each time point (15%-45%). These findings lend support to routine antenatal supplementation with vitamin D in at risk populations.
Item Type:
Article
Language:
en
Keywords:
PREGNANCY; NUTRITION
Local subject classification:
FOETAL DEVELOPMENT
MeSH:
Adiposity; Biological Markers; Blood Glucose; Female; Fetal Blood; Fetal Development; Fetal Macrosomia; Gestational Age; Homeostasis; Humans; Insulin; Insulin Resistance; Leptin; Longitudinal Studies; Pregnancy; Prospective Studies; Risk Factors; Vitamin D; Vitamin D Deficiency
ISSN:
1933-7205

Full metadata record

DC FieldValue Language
dc.contributor.authorWalsh, Jennifer Men_GB
dc.contributor.authorMcGowan, Ciara Aen_GB
dc.contributor.authorKilbane, Marken_GB
dc.contributor.authorMcKenna, Malachi Jen_GB
dc.contributor.authorMcAuliffe, Fionnuala Men_GB
dc.date.accessioned2014-04-10T09:36:09Z-
dc.date.available2014-04-10T09:36:09Z-
dc.date.issued2013-05-
dc.identifier.citationThe relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth. 2013, 20 (5):536-41 Reprod Scien_GB
dc.identifier.issn1933-7205-
dc.identifier.pmid22968764-
dc.identifier.doi10.1177/1933719112459222-
dc.identifier.urihttp://hdl.handle.net/10147/315564-
dc.description.abstractEvidence for a role of vitamin D in maintaining normal glucose homeostasis is inconclusive. We sought to clarify the relationship between maternal and fetal insulin resistance and vitamin D status. This is a prospective cohort study of 60 caucasian pregnant women. Concentrations of 25-hydroxyvitamin D (25-OHD), glucose, insulin, and leptin were measured in early pregnancy and at 28 weeks. Ultrasound at 34 weeks assessed fetal anthropometry including abdominal wall width, a marker of fetal adiposity. At delivery birth weight was recorded and fetal 25-OHD, glucose, C-peptide, and leptin measured in cord blood. Insulin resistance was calculated using the Homeostasis Model Assessment (HOMA) equation. We found that those with lower 25-OHD in early pregnancy had higher HOMA indices at 28 weeks, (r = -.32, P = .02). No significant relationship existed between maternal or fetal leptin and 25-OHD, or between maternal or fetal 25-OHD and fetal anthropometry or birth weight. The incidence of vitamin D deficiency was high at each time point (15%-45%). These findings lend support to routine antenatal supplementation with vitamin D in at risk populations.en_GB
dc.language.isoenen
dc.relation.urlhttp://rsx.sagepub.com/content/20/5/536.longen_GB
dc.rightsArchived with thanks to Reproductive sciences (Thousand Oaks, Calif.)en_GB
dc.subjectPREGNANCYen_GB
dc.subjectNUTRITIONen_GB
dc.subject.meshAdiposity-
dc.subject.meshBiological Markers-
dc.subject.meshBlood Glucose-
dc.subject.meshFemale-
dc.subject.meshFetal Blood-
dc.subject.meshFetal Development-
dc.subject.meshFetal Macrosomia-
dc.subject.meshGestational Age-
dc.subject.meshHomeostasis-
dc.subject.meshHumans-
dc.subject.meshInsulin-
dc.subject.meshInsulin Resistance-
dc.subject.meshLeptin-
dc.subject.meshLongitudinal Studies-
dc.subject.meshPregnancy-
dc.subject.meshProspective Studies-
dc.subject.meshRisk Factors-
dc.subject.meshVitamin D-
dc.subject.meshVitamin D Deficiency-
dc.subject.otherFOETAL DEVELOPMENTen_GB
dc.titleThe relationship between maternal and fetal vitamin D, insulin resistance, and fetal growth.en_GB
dc.typeArticleen
dc.contributor.departmentUCD Obstetrics and Gynaecology, School of Medicine and Medical Science, University College Dublin, National Maternity Hospital, Dublin, Irelanden_GB
dc.identifier.journalReproductive sciences (Thousand Oaks, Calif.)en_GB
dc.description.fundingHRB Health Research Boarden
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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