Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)

Hdl Handle:
http://hdl.handle.net/10147/315457
Title:
Computed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)
Authors:
Chow, Benjamin JW; Green, Rachel E; Coyle, Doug; Laine, Mika; Hanninen, Helena; Leskinen, Hanna; Rajda, Miroslav; Larose, Eric; Hartikainen, Juha; Hedman, Marja; Mielniczuk, Lisa; O’Meara, Eileen; deKemp, Robert A; Klein, Ran; Paterson, Ian; White, James A; Yla-Herttuala, Seppo; Leber, Alex; Tandon, Vikas; Lee, Ting; Al-Hesayen, Abdul; Hessian, Renee; Dowsley, Taylor; Kass, Malek; Kelly, Cathy; Garrard, Linda; Tardif, Jean-Claude; Knuuti, Juhani; Beanlands, Rob S; Wells, George A; on behalf of the IMAGE-HF Investigators
Citation:
Trials. 2013 Dec 26;14(1):443
Issue Date:
26-Dec-2013
URI:
http://dx.doi.org/10.1186/1745-6215-14-443; http://hdl.handle.net/10147/315457
Abstract:
Abstract Background The prevalence of heart failure (HF) is rising in industrialized and developing countries. Though invasive coronary angiography (ICA) remains the gold standard for anatomical assessment of coronary artery disease in HF patients, alternatives are being sought. Computed tomographic coronary angiography (CTA) has emerged as an accurate non-invasive diagnostic tool for coronary artery disease (CAD) and has been demonstrated to have prognostic value. Whether or not CTA can be used in HF patients is unknown. Acknowledging the aging population, the growing prevalence of HF and the increasing financial burden of healthcare, we need to identify non-invasive diagnostic tests that are available, safe, accurate and cost-effective. Methods/Design The proposed study aims to provide insight into the efficacy of CTA in HF patients. A multicenter randomized controlled trial will enroll 250 HF patients requiring coronary anatomical definition. Enrolled patients will be randomized to either CTA or ICA (n = 125 per group) as the first test to define coronary anatomy. The primary outcomes will be collected to determine downstream resource utilization. Secondary outcomes will include the composite clinical events and major adverse cardiac events. In addition, the accuracy of CTA for detecting coronary anatomy and obstruction will be assessed in patients who subsequently undergo both CTA and ICA. It is expected that CTA will be a more cost-effective strategy for diagnosis: yielding similar outcomes with fewer procedural risks and improved resource utilization. Trial registration ClinicalTrials.gov, NCT01283659 Team grant #CIF 99470
Item Type:
Article
Language:
en
Keywords:
HEART FAILURE

Full metadata record

DC FieldValue Language
dc.contributor.authorChow, Benjamin JWen_GB
dc.contributor.authorGreen, Rachel Een_GB
dc.contributor.authorCoyle, Dougen_GB
dc.contributor.authorLaine, Mikaen_GB
dc.contributor.authorHanninen, Helenaen_GB
dc.contributor.authorLeskinen, Hannaen_GB
dc.contributor.authorRajda, Miroslaven_GB
dc.contributor.authorLarose, Ericen_GB
dc.contributor.authorHartikainen, Juhaen_GB
dc.contributor.authorHedman, Marjaen_GB
dc.contributor.authorMielniczuk, Lisaen_GB
dc.contributor.authorO’Meara, Eileenen_GB
dc.contributor.authordeKemp, Robert Aen_GB
dc.contributor.authorKlein, Ranen_GB
dc.contributor.authorPaterson, Ianen_GB
dc.contributor.authorWhite, James Aen_GB
dc.contributor.authorYla-Herttuala, Seppoen_GB
dc.contributor.authorLeber, Alexen_GB
dc.contributor.authorTandon, Vikasen_GB
dc.contributor.authorLee, Tingen_GB
dc.contributor.authorAl-Hesayen, Abdulen_GB
dc.contributor.authorHessian, Reneeen_GB
dc.contributor.authorDowsley, Tayloren_GB
dc.contributor.authorKass, Maleken_GB
dc.contributor.authorKelly, Cathyen_GB
dc.contributor.authorGarrard, Lindaen_GB
dc.contributor.authorTardif, Jean-Claudeen_GB
dc.contributor.authorKnuuti, Juhanien_GB
dc.contributor.authorBeanlands, Rob Sen_GB
dc.contributor.authorWells, George Aen_GB
dc.contributor.authoron behalf of the IMAGE-HF Investigatorsen_GB
dc.date.accessioned2014-04-07T10:48:49Z-
dc.date.available2014-04-07T10:48:49Z-
dc.date.issued2013-12-26-
dc.identifier.citationTrials. 2013 Dec 26;14(1):443en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1745-6215-14-443-
dc.identifier.urihttp://hdl.handle.net/10147/315457-
dc.description.abstractAbstract Background The prevalence of heart failure (HF) is rising in industrialized and developing countries. Though invasive coronary angiography (ICA) remains the gold standard for anatomical assessment of coronary artery disease in HF patients, alternatives are being sought. Computed tomographic coronary angiography (CTA) has emerged as an accurate non-invasive diagnostic tool for coronary artery disease (CAD) and has been demonstrated to have prognostic value. Whether or not CTA can be used in HF patients is unknown. Acknowledging the aging population, the growing prevalence of HF and the increasing financial burden of healthcare, we need to identify non-invasive diagnostic tests that are available, safe, accurate and cost-effective. Methods/Design The proposed study aims to provide insight into the efficacy of CTA in HF patients. A multicenter randomized controlled trial will enroll 250 HF patients requiring coronary anatomical definition. Enrolled patients will be randomized to either CTA or ICA (n = 125 per group) as the first test to define coronary anatomy. The primary outcomes will be collected to determine downstream resource utilization. Secondary outcomes will include the composite clinical events and major adverse cardiac events. In addition, the accuracy of CTA for detecting coronary anatomy and obstruction will be assessed in patients who subsequently undergo both CTA and ICA. It is expected that CTA will be a more cost-effective strategy for diagnosis: yielding similar outcomes with fewer procedural risks and improved resource utilization. Trial registration ClinicalTrials.gov, NCT01283659 Team grant #CIF 99470-
dc.language.isoenen
dc.subjectHEART FAILUREen_GB
dc.titleComputed tomographic coronary angiography for patients with heart failure (CTA-HF): a randomized controlled trial (IMAGE HF Project 1-C)en_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderBenjamin JW Chow et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2014-04-05T11:19:20Z-
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