Distribution of tract deficits in schizophrenia

Hdl Handle:
http://hdl.handle.net/10147/315319
Title:
Distribution of tract deficits in schizophrenia
Authors:
Ellison-Wright, Ian; Nathan, Pradeep J; Bullmore, Edward T; Zaman, Rashid; Dudas, Robert B; Agius, Mark; Fernandez-Egea, Emilio; Müller, Ulrich; Dodds, Chris M; Forde, Natalie J; Scanlon, Cathy; Leemans, Alexander; McDonald, Colm; Cannon, Dara M
Citation:
BMC Psychiatry. 2014 Apr 02;14(1):99
Issue Date:
2-Apr-2014
URI:
http://dx.doi.org/10.1186/1471-244X-14-99; http://hdl.handle.net/10147/315319
Abstract:
Abstract Background Gray and white matter brain changes have been found in schizophrenia but the anatomical organizing process underlying these changes remains unknown. We aimed to identify gray and white matter volumetric changes in a group of patients with schizophrenia and to quantify the distribution of white matter tract changes using a novel approach which applied three complementary analyses to diffusion imaging data. Methods 21 patients with schizophrenia and 21 matched control subjects underwent brain magnetic resonance imaging. Gray and white matter volume differences were investigated using Voxel-based Morphometry (VBM). White matter diffusion changes were located using Tract Based Spatial Statistics (TBSS) and quantified within a standard atlas. Tracts where significant regional differences were located were examined using fiber tractography. Results No significant differences in gray or white matter volumetry were found between the two groups. Using TBSS the schizophrenia group showed significantly lower fractional anisotropy (FA) compared to the controls in regions (false discovery rate <0.05) including the genu, body and splenium of the corpus callosum and the left anterior limb of the internal capsule (ALIC). Using fiber tractography, FA was significantly lower in schizophrenia in the corpus callosum genu (p = 0.003). Conclusions In schizophrenia, white matter diffusion deficits are prominent in medial frontal regions. These changes are consistent with the results of previous studies which have detected white matter changes in these areas. The pathology of schizophrenia may preferentially affect the prefrontal-thalamic white matter circuits traversing these regions.
Item Type:
Article
Language:
en
Keywords:
MENTAL HEALTH; SCHIZOPHRENIA

Full metadata record

DC FieldValue Language
dc.contributor.authorEllison-Wright, Ianen_GB
dc.contributor.authorNathan, Pradeep Jen_GB
dc.contributor.authorBullmore, Edward Ten_GB
dc.contributor.authorZaman, Rashiden_GB
dc.contributor.authorDudas, Robert Ben_GB
dc.contributor.authorAgius, Marken_GB
dc.contributor.authorFernandez-Egea, Emilioen_GB
dc.contributor.authorMüller, Ulrichen_GB
dc.contributor.authorDodds, Chris Men_GB
dc.contributor.authorForde, Natalie Jen_GB
dc.contributor.authorScanlon, Cathyen_GB
dc.contributor.authorLeemans, Alexanderen_GB
dc.contributor.authorMcDonald, Colmen_GB
dc.contributor.authorCannon, Dara Men_GB
dc.date.accessioned2014-04-04T09:58:10Z-
dc.date.available2014-04-04T09:58:10Z-
dc.date.issued2014-04-02-
dc.identifier.citationBMC Psychiatry. 2014 Apr 02;14(1):99en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1471-244X-14-99-
dc.identifier.urihttp://hdl.handle.net/10147/315319-
dc.description.abstractAbstract Background Gray and white matter brain changes have been found in schizophrenia but the anatomical organizing process underlying these changes remains unknown. We aimed to identify gray and white matter volumetric changes in a group of patients with schizophrenia and to quantify the distribution of white matter tract changes using a novel approach which applied three complementary analyses to diffusion imaging data. Methods 21 patients with schizophrenia and 21 matched control subjects underwent brain magnetic resonance imaging. Gray and white matter volume differences were investigated using Voxel-based Morphometry (VBM). White matter diffusion changes were located using Tract Based Spatial Statistics (TBSS) and quantified within a standard atlas. Tracts where significant regional differences were located were examined using fiber tractography. Results No significant differences in gray or white matter volumetry were found between the two groups. Using TBSS the schizophrenia group showed significantly lower fractional anisotropy (FA) compared to the controls in regions (false discovery rate <0.05) including the genu, body and splenium of the corpus callosum and the left anterior limb of the internal capsule (ALIC). Using fiber tractography, FA was significantly lower in schizophrenia in the corpus callosum genu (p = 0.003). Conclusions In schizophrenia, white matter diffusion deficits are prominent in medial frontal regions. These changes are consistent with the results of previous studies which have detected white matter changes in these areas. The pathology of schizophrenia may preferentially affect the prefrontal-thalamic white matter circuits traversing these regions.-
dc.language.isoenen
dc.subjectMENTAL HEALTHen_GB
dc.subjectSCHIZOPHRENIAen_GB
dc.titleDistribution of tract deficits in schizophreniaen_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderIan Ellison-Wright et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2014-04-03T23:07:01Z-
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