Pediatric renal transplantation in a highly sensitised child-8 years on.

Hdl Handle:
http://hdl.handle.net/10147/314750
Title:
Pediatric renal transplantation in a highly sensitised child-8 years on.
Authors:
Quinlan, Catherine; Awan, Atif; Gill, Denis; Waldron, Mary; Little, Dilly; Hickey, David; Conlon, Peter; Keogan, Mary
Citation:
Pediatric renal transplantation in a highly sensitised child-8 years on. 2011, 2011:370596 Case Rep Transplant
Journal:
Case reports in transplantation
Issue Date:
26-Jan-2012
URI:
http://hdl.handle.net/10147/314750
DOI:
10.1155/2011/370596
PubMed ID:
23198257
Abstract:
Highly sensitised children have markedly reduced chances of receiving a successful deceased donor renal transplant, increased risk of rejection, and decreased graft survival. There is limited experience with the long-term followup of children who have undergone desensitization. Following 2 failed transplants, our patient was highly sensitised. She had some immunological response to intravenous immunoglobulin (IVIg) but this was not sustained. We developed a protocol involving sequential therapies with rituximab, IVIg, and plasma exchange. Immunosuppressant therapy at transplantation consisted of basiliximab, tacrolimus, mycophenolate mofetil, and steroids. At the time of transplantation, historical crossmatch was ignored. Current CDC crossmatch was negative, but T and B cell flow crossmatch was positive, due to donor-specific HLA Class I antibodies. Further plasma exchange and immunoglobulin therapy were given pre- and postoperatively. Our patient received a deceased donor-kidney-bearing HLA antigens to which she originally had antibodies, which would have precluded transplant. The graft kidney continues to function well 8 years posttransplant.
Item Type:
Article
Language:
en
Keywords:
KIDNEY DISEASE; TRANSPLANTATION
ISSN:
2090-6951

Full metadata record

DC FieldValue Language
dc.contributor.authorQuinlan, Catherineen_GB
dc.contributor.authorAwan, Atifen_GB
dc.contributor.authorGill, Denisen_GB
dc.contributor.authorWaldron, Maryen_GB
dc.contributor.authorLittle, Dillyen_GB
dc.contributor.authorHickey, Daviden_GB
dc.contributor.authorConlon, Peteren_GB
dc.contributor.authorKeogan, Maryen_GB
dc.date.accessioned2014-03-26T16:19:43Z-
dc.date.available2014-03-26T16:19:43Z-
dc.date.issued2012-01-26-
dc.identifier.citationPediatric renal transplantation in a highly sensitised child-8 years on. 2011, 2011:370596 Case Rep Transplanten_GB
dc.identifier.issn2090-6951-
dc.identifier.pmid23198257-
dc.identifier.doi10.1155/2011/370596-
dc.identifier.urihttp://hdl.handle.net/10147/314750-
dc.description.abstractHighly sensitised children have markedly reduced chances of receiving a successful deceased donor renal transplant, increased risk of rejection, and decreased graft survival. There is limited experience with the long-term followup of children who have undergone desensitization. Following 2 failed transplants, our patient was highly sensitised. She had some immunological response to intravenous immunoglobulin (IVIg) but this was not sustained. We developed a protocol involving sequential therapies with rituximab, IVIg, and plasma exchange. Immunosuppressant therapy at transplantation consisted of basiliximab, tacrolimus, mycophenolate mofetil, and steroids. At the time of transplantation, historical crossmatch was ignored. Current CDC crossmatch was negative, but T and B cell flow crossmatch was positive, due to donor-specific HLA Class I antibodies. Further plasma exchange and immunoglobulin therapy were given pre- and postoperatively. Our patient received a deceased donor-kidney-bearing HLA antigens to which she originally had antibodies, which would have precluded transplant. The graft kidney continues to function well 8 years posttransplant.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Case reports in transplantationen_GB
dc.subjectKIDNEY DISEASEen_GB
dc.subjectTRANSPLANTATIONen_GB
dc.titlePediatric renal transplantation in a highly sensitised child-8 years on.en_GB
dc.typeArticleen
dc.identifier.journalCase reports in transplantationen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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