Leptin levels in children and adults with classic galactosaemia.

Hdl Handle:
http://hdl.handle.net/10147/314748
Title:
Leptin levels in children and adults with classic galactosaemia.
Authors:
Knerr, Ina; Coss, Karen P; Doran, Peter P; Hughes, Joanne; Wareham, Nick; Burling, Keith; Treacy, Eileen P
Citation:
Leptin levels in children and adults with classic galactosaemia. 2013, 9:125-31 JIMD Rep
Publisher:
Springer
Journal:
JIMD reports
Issue Date:
7-Nov-2012
URI:
http://hdl.handle.net/10147/314748
DOI:
10.1007/8904_2012_191
PubMed ID:
23430559
Abstract:
Among the long-term complications of Classic Galactosaemia (Gal) is premature ovarian insufficiency (POI) in female patients with subtle abnormalities of reproductive function also reported in male patients. Leptin is a circulating hormone which reflects body energy stores and which affects the neuroendocrine reproductive axis and pubertal development.We measured serum leptin in 28 children (10 girls, 18 boys; mean age 7.6 years, range 0.5-17.9 years) and in 22 adults (10 females, 12 males; mean age 23.9 years, range 18-37 years) with Gal on a strict galactose-restricted diet in comparison with control data.Leptin levels (expressed as SDS for gender and pubertal stage) were lower in Gal children than controls (mean leptin-SDS = -0.71 for girls, p < 0.05, -0.97 for boys compared with SDS = 0 for controls, p < 0.05). In an age-related analysis, leptin levels did not correlate with age in children with Gal for both sexes as it did for matched controls.As expected, females had higher leptin levels than males in either group. In adults with Gal, leptin concentrations were within normal limits for both sexes when adjusted for gender and BMI. There was a linear relationship between log-leptin and BMI in children with Gal and in controls. For Gal women, log-leptin was also associated with BMI. However, for Gal men, and hence for the entire group of adult Gal patients, this association between log-leptin and BMI was not detectable. Our findings suggest that leptin dysregulation may play a role in fertility issues in individuals with Gal from an early age.
Item Type:
Article
Language:
en
Keywords:
BLOOD AND IMMUNE DISORDER
ISSN:
2192-8304

Full metadata record

DC FieldValue Language
dc.contributor.authorKnerr, Inaen_GB
dc.contributor.authorCoss, Karen Pen_GB
dc.contributor.authorDoran, Peter Pen_GB
dc.contributor.authorHughes, Joanneen_GB
dc.contributor.authorWareham, Nicken_GB
dc.contributor.authorBurling, Keithen_GB
dc.contributor.authorTreacy, Eileen Pen_GB
dc.date.accessioned2014-03-26T16:15:40Z-
dc.date.available2014-03-26T16:15:40Z-
dc.date.issued2012-11-07-
dc.identifier.citationLeptin levels in children and adults with classic galactosaemia. 2013, 9:125-31 JIMD Repen_GB
dc.identifier.issn2192-8304-
dc.identifier.pmid23430559-
dc.identifier.doi10.1007/8904_2012_191-
dc.identifier.urihttp://hdl.handle.net/10147/314748-
dc.description.abstractAmong the long-term complications of Classic Galactosaemia (Gal) is premature ovarian insufficiency (POI) in female patients with subtle abnormalities of reproductive function also reported in male patients. Leptin is a circulating hormone which reflects body energy stores and which affects the neuroendocrine reproductive axis and pubertal development.We measured serum leptin in 28 children (10 girls, 18 boys; mean age 7.6 years, range 0.5-17.9 years) and in 22 adults (10 females, 12 males; mean age 23.9 years, range 18-37 years) with Gal on a strict galactose-restricted diet in comparison with control data.Leptin levels (expressed as SDS for gender and pubertal stage) were lower in Gal children than controls (mean leptin-SDS = -0.71 for girls, p < 0.05, -0.97 for boys compared with SDS = 0 for controls, p < 0.05). In an age-related analysis, leptin levels did not correlate with age in children with Gal for both sexes as it did for matched controls.As expected, females had higher leptin levels than males in either group. In adults with Gal, leptin concentrations were within normal limits for both sexes when adjusted for gender and BMI. There was a linear relationship between log-leptin and BMI in children with Gal and in controls. For Gal women, log-leptin was also associated with BMI. However, for Gal men, and hence for the entire group of adult Gal patients, this association between log-leptin and BMI was not detectable. Our findings suggest that leptin dysregulation may play a role in fertility issues in individuals with Gal from an early age.en_GB
dc.language.isoenen
dc.publisherSpringeren_GB
dc.rightsArchived with thanks to JIMD reportsen_GB
dc.subjectBLOOD AND IMMUNE DISORDERen_GB
dc.titleLeptin levels in children and adults with classic galactosaemia.en_GB
dc.typeArticleen
dc.identifier.journalJIMD reportsen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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