Genetic Pre-determinants of Concurrent Alcohol and Opioid Dependence: A critical review

Hdl Handle:
http://hdl.handle.net/10147/313973
Title:
Genetic Pre-determinants of Concurrent Alcohol and Opioid Dependence: A critical review
Authors:
Marissa Martin; Jan Klimas; Colum Dunne; David Meagher; William T. O'Connor; Patrick O'Dwyer; Bobby P. Smyth; Walter Cullen
Affiliation:
1Graduate Entry Medical School, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland 2School of Medicine and Medical Science, University College Dublin, Dublin, Ireland 3Department of Public Health and Primary care, Trinity College Dublin, Ireland 4Addiction Services, Health Service Executive, Dublin, Ireland 5Flinders University School of Medicine, Bedford Park, SA 5042, Australia
Citation:
Martin, M., Klimas, J., Dunne, C., Meagher, D., O'Connor, W.T., O’Dwyer, P., Smyth, B.P., Cullen, W. (2013) Genetic Pre-determinants of Concurrent Alcohol and Opioid Dependence: A critical review. OA Alcohol, 1(2):18
Journal:
Open Access Alcohol
Issue Date:
1-Nov-2013
URI:
http://hdl.handle.net/10147/313973
Item Type:
Article
Language:
en
Description:
Concurrent alcohol dependence poses a significant burden to health and wellbeing of people with established opioid dependence. Although previous research indicates that both genetic and environmental risk factors contribute to the development of drug or alcohol dependence, the role of genetic determinants in development of concurrent alcohol and opioid dependence has not been scrutinised. To search for genetic pre-determinants of concurrent alcohol and opioid dependence, electronic literature searches were completed using MEDLINE (PubMed) and EBSCO (Academic Search Complete) databases. Reference lists of included studies were also searched. In this discussion paper, we provide an overview of the genes (n=33) which are associated with the opioid, serotonergic, dopaminergic, GABA-ergic, cannabinoid, and metabolic systems for each dependency (i.e., alcohol or opioid) separately. The current evidence base is inconclusive regarding an exclusively genetic pre-determinant of concurrent alcohol and opioid dependence. Further search strategies and original research are needed to determine the genetic basis for concurrent alcohol and opioid dependency.
Keywords:
ALCOHOL MISUSE; ALCOHOL; RISK FACTOR
Local subject classification:
OPIOID DEPENDENCE; GENETICS; WELL BEING

Full metadata record

DC FieldValue Language
dc.contributor.authorMarissa Martinen_GB
dc.contributor.authorJan Klimasen_GB
dc.contributor.authorColum Dunneen_GB
dc.contributor.authorDavid Meagheren_GB
dc.contributor.authorWilliam T. O'Connoren_GB
dc.contributor.authorPatrick O'Dwyeren_GB
dc.contributor.authorBobby P. Smythen_GB
dc.contributor.authorWalter Cullenen_GB
dc.date.accessioned2014-03-12T12:21:12Z-
dc.date.available2014-03-12T12:21:12Z-
dc.date.issued2013-11-01-
dc.identifier.citationMartin, M., Klimas, J., Dunne, C., Meagher, D., O'Connor, W.T., O’Dwyer, P., Smyth, B.P., Cullen, W. (2013) Genetic Pre-determinants of Concurrent Alcohol and Opioid Dependence: A critical review. OA Alcohol, 1(2):18en_GB
dc.identifier.urihttp://hdl.handle.net/10147/313973-
dc.descriptionConcurrent alcohol dependence poses a significant burden to health and wellbeing of people with established opioid dependence. Although previous research indicates that both genetic and environmental risk factors contribute to the development of drug or alcohol dependence, the role of genetic determinants in development of concurrent alcohol and opioid dependence has not been scrutinised. To search for genetic pre-determinants of concurrent alcohol and opioid dependence, electronic literature searches were completed using MEDLINE (PubMed) and EBSCO (Academic Search Complete) databases. Reference lists of included studies were also searched. In this discussion paper, we provide an overview of the genes (n=33) which are associated with the opioid, serotonergic, dopaminergic, GABA-ergic, cannabinoid, and metabolic systems for each dependency (i.e., alcohol or opioid) separately. The current evidence base is inconclusive regarding an exclusively genetic pre-determinant of concurrent alcohol and opioid dependence. Further search strategies and original research are needed to determine the genetic basis for concurrent alcohol and opioid dependency.en_GB
dc.language.isoenen
dc.subjectALCOHOL MISUSEen_GB
dc.subjectALCOHOLen_GB
dc.subjectRISK FACTORen_GB
dc.subject.otherOPIOID DEPENDENCEen_GB
dc.subject.otherGENETICSen_GB
dc.subject.otherWELL BEINGen_GB
dc.titleGenetic Pre-determinants of Concurrent Alcohol and Opioid Dependence: A critical reviewen_GB
dc.typeArticleen
dc.contributor.department1Graduate Entry Medical School, Faculty of Education and Health Sciences, University of Limerick, Limerick, Ireland 2School of Medicine and Medical Science, University College Dublin, Dublin, Ireland 3Department of Public Health and Primary care, Trinity College Dublin, Ireland 4Addiction Services, Health Service Executive, Dublin, Ireland 5Flinders University School of Medicine, Bedford Park, SA 5042, Australiaen_GB
dc.identifier.journalOpen Access Alcoholen_GB
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