Authors
Kent, Brian DLane, Stephen J
van Beek, Edwin J
Dodd, Jonathan D
Costello, Richard W
Tiddens, Harm A W M
Issue Date
2014-03Keywords
ASTHMACYSTIC FIBROSIS
Metadata
Show full item recordCitation
Asthma and cystic fibrosis: A tangled web. 2014, 49 (3):205-13 Pediatr. Pulmonol.Journal
Pediatric pulmonologyDOI
10.1002/ppul.22934PubMed ID
24420817Abstract
Successfully diagnosing concomitant asthma in people with cystic fibrosis (CF) is a challenging proposition, and the utility of conventional diagnostic criteria of asthma in CF populations remains uncertain. Nonetheless, the accurate identification of individuals with CF and asthma allows appropriate tailoring of therapy, and should reduce the unnecessary use of asthma medication in broader CF cohorts. In this review, we discuss the diagnostic challenge posed by asthma in CF, both in terms of clinical evaluation, and of interpretation of pulmonary function testing and non-invasive markers of airway inflammation. We also examine how the role of cross-sectional thoracic imaging in CF and asthma can assist in the diagnosis of asthma in these patients. Finally, we critically appraise the evidence base behind the use of asthma medications in CF populations, with a particular focus on the use of inhaled corticosteroids and bronchodilators. As shall be discussed, the gaps in the current literature make further high-quality research in this field imperative. Pediatr Pulmonol. 2014; 49:205-213. © 2014 Wiley Periodicals, Inc.Item Type
ArticleLanguage
enISSN
1099-0496ae974a485f413a2113503eed53cd6c53
10.1002/ppul.22934
Scopus Count
Collections
Related articles
- Cystic fibrosis, atopy, asthma and ABPA.
- Authors: Antunes J, Fernandes A, Borrego LM, Leiria-Pinto P, Cavaco J
- Issue date: 2010 Sep-Oct
- Airways reactivity in patients with CF.
- Authors: Weinberger M
- Issue date: 2002 Aug
- Rapid onset of iatrogenic adrenal insufficiency in a patient with cystic fibrosis-related liver disease treated with inhaled corticosteroids and a moderate CYP3A4 inhibitor.
- Authors: Hoover WC, Britton LJ, Gardner J, Jackson T, Gutierrez H
- Issue date: 2011 Jul
- "CF asthma": what is it and what do we do about it?
- Authors: Balfour-Lynn IM, Elborn JS
- Issue date: 2002 Aug
- Pulmonary mechanics in asthma and cystic fibrosis.
- Authors: Zapletal A, Motoyama EK, Gibson LE, Bouhuys A
- Issue date: 1971 Jul