Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases.

Hdl Handle:
http://hdl.handle.net/10147/313208
Title:
Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases.
Authors:
Sheridan, Juliette; Tosetto, Miriam; Gorman, Julie; O'Donoghue, Diarmuid; Sheahan, Kieran; Hyland, John; Mulcahy, Hugh; Gibbons, David; O'Sullivan, Jacintha
Affiliation:
Centre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
Citation:
Effects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases. 2013, 44 (1):41-5 J Gastrointest Cancer
Journal:
Journal of gastrointestinal cancer
Issue Date:
Mar-2013
URI:
http://hdl.handle.net/10147/313208
DOI:
10.1007/s12029-012-9442-x
PubMed ID:
23065707
Abstract:
Defects in DNA repair pathways have been linked with colorectal cancer (CRC). Adjuvant radiotherapy has become commonplace in the treatment of rectal cancer however it is associated with a higher rate of second cancer formation. It is known that radiation results in DNA damage directly or indirectly by radiation-induced bystander effect (RIBE) by causing double-strand breaks (DSBs). The majority of work in RIBE has been performed in cell lines and limited studies have been in or ex vivo.
Item Type:
Article
Language:
en
MeSH:
Adolescent; Adult; Aged; Aged, 80 and over; Bystander Effect; Colon; Colorectal Neoplasms; DNA Damage; DNA-Binding Proteins; Feasibility Studies; Female; Genomic Instability; Humans; Immunoenzyme Techniques; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Prognosis; Radiotherapy Dosage; Radiotherapy, Adjuvant; Rectum; Tissue Array Analysis; Young Adult
ISSN:
1941-6636

Full metadata record

DC FieldValue Language
dc.contributor.authorSheridan, Julietteen_GB
dc.contributor.authorTosetto, Miriamen_GB
dc.contributor.authorGorman, Julieen_GB
dc.contributor.authorO'Donoghue, Diarmuiden_GB
dc.contributor.authorSheahan, Kieranen_GB
dc.contributor.authorHyland, Johnen_GB
dc.contributor.authorMulcahy, Hughen_GB
dc.contributor.authorGibbons, Daviden_GB
dc.contributor.authorO'Sullivan, Jacinthaen_GB
dc.date.accessioned2014-02-21T15:51:22Z-
dc.date.available2014-02-21T15:51:22Z-
dc.date.issued2013-03-
dc.identifier.citationEffects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases. 2013, 44 (1):41-5 J Gastrointest Canceren_GB
dc.identifier.issn1941-6636-
dc.identifier.pmid23065707-
dc.identifier.doi10.1007/s12029-012-9442-x-
dc.identifier.urihttp://hdl.handle.net/10147/313208-
dc.description.abstractDefects in DNA repair pathways have been linked with colorectal cancer (CRC). Adjuvant radiotherapy has become commonplace in the treatment of rectal cancer however it is associated with a higher rate of second cancer formation. It is known that radiation results in DNA damage directly or indirectly by radiation-induced bystander effect (RIBE) by causing double-strand breaks (DSBs). The majority of work in RIBE has been performed in cell lines and limited studies have been in or ex vivo.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Journal of gastrointestinal canceren_GB
dc.subject.meshAdolescent-
dc.subject.meshAdult-
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshBystander Effect-
dc.subject.meshColon-
dc.subject.meshColorectal Neoplasms-
dc.subject.meshDNA Damage-
dc.subject.meshDNA-Binding Proteins-
dc.subject.meshFeasibility Studies-
dc.subject.meshFemale-
dc.subject.meshGenomic Instability-
dc.subject.meshHumans-
dc.subject.meshImmunoenzyme Techniques-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshNeoadjuvant Therapy-
dc.subject.meshNeoplasm Staging-
dc.subject.meshPrognosis-
dc.subject.meshRadiotherapy Dosage-
dc.subject.meshRadiotherapy, Adjuvant-
dc.subject.meshRectum-
dc.subject.meshTissue Array Analysis-
dc.subject.meshYoung Adult-
dc.titleEffects of radiation on levels of DNA damage in normal non-adjacent mucosa from colorectal cancer cases.en_GB
dc.typeArticleen
dc.contributor.departmentCentre for Colorectal Disease, St. Vincent's University Hospital, Elm Park, Dublin 4, Ireland.en_GB
dc.identifier.journalJournal of gastrointestinal canceren_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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