Virulence characteristics of five new Campylobacter jejuni chicken isolates

Hdl Handle:
http://hdl.handle.net/10147/307074
Title:
Virulence characteristics of five new Campylobacter jejuni chicken isolates
Authors:
Stef, Lavinia; Cean, Ada; Vasile, Aida; Julean, Calin; Drinceanu, Dan; Corcionivoschi, Nicolae
Citation:
Gut Pathogens. 2013 Dec 13;5(1):41
Issue Date:
13-Dec-2013
URI:
http://dx.doi.org/10.1186/1757-4749-5-41; http://hdl.handle.net/10147/307074
Abstract:
Abstract Campylobacter enteritis has emerged as one of the most common forms of human diarrheal illness. In this study we have investigated the virulence potential of five new C. jejuni chicken isolates (RO14, RO19, RO24, RO29 and RO37) originated from private households in the rural regions of Banat and Transylvania in Romania. Following isolation and in vitro virulence assay, on HCT-8 cells, our results show that all the C. jejuni chicken isolates overcome the virulence abilities of the highly virulent strain C. jejuni 81-176. Motility, an important virulence factor was significantly improved in all the new chicken isolates. The ability to survive to the antimicrobial activity of the human serum, to resist to the violent attack of bile acids and to survive in the presence of synthetic antibiotics was increased in all the chicken isolates. However, these were statistically significant only for isolates RO29 and RO37. In conclusion our study shows, based on invasiveness and motility, and also on the data provided by the serum and bile resistance experiments that all the new chicken isolates are able to infect human cells, in vitro, and could potentially represent a health hazard for humans.
Item Type:
Article
Language:
en
Keywords:
GUT; INFECTION CONTROL

Full metadata record

DC FieldValue Language
dc.contributor.authorStef, Laviniaen_GB
dc.contributor.authorCean, Adaen_GB
dc.contributor.authorVasile, Aidaen_GB
dc.contributor.authorJulean, Calinen_GB
dc.contributor.authorDrinceanu, Danen_GB
dc.contributor.authorCorcionivoschi, Nicolaeen_GB
dc.date.accessioned2013-12-18T16:38:44Z-
dc.date.available2013-12-18T16:38:44Z-
dc.date.issued2013-12-13-
dc.identifier.citationGut Pathogens. 2013 Dec 13;5(1):41en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1757-4749-5-41-
dc.identifier.urihttp://hdl.handle.net/10147/307074-
dc.description.abstractAbstract Campylobacter enteritis has emerged as one of the most common forms of human diarrheal illness. In this study we have investigated the virulence potential of five new C. jejuni chicken isolates (RO14, RO19, RO24, RO29 and RO37) originated from private households in the rural regions of Banat and Transylvania in Romania. Following isolation and in vitro virulence assay, on HCT-8 cells, our results show that all the C. jejuni chicken isolates overcome the virulence abilities of the highly virulent strain C. jejuni 81-176. Motility, an important virulence factor was significantly improved in all the new chicken isolates. The ability to survive to the antimicrobial activity of the human serum, to resist to the violent attack of bile acids and to survive in the presence of synthetic antibiotics was increased in all the chicken isolates. However, these were statistically significant only for isolates RO29 and RO37. In conclusion our study shows, based on invasiveness and motility, and also on the data provided by the serum and bile resistance experiments that all the new chicken isolates are able to infect human cells, in vitro, and could potentially represent a health hazard for humans.-
dc.language.isoenen
dc.subjectGUTen_GB
dc.subjectINFECTION CONTROLen_GB
dc.titleVirulence characteristics of five new Campylobacter jejuni chicken isolatesen_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderLavinia Stef et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-12-18T16:11:43Z-
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