The Intensity of QuantiFERON TB-Gold Response does not Differentiate Active from Latent Tuberculosis

Hdl Handle:
http://hdl.handle.net/10147/307036
Title:
The Intensity of QuantiFERON TB-Gold Response does not Differentiate Active from Latent Tuberculosis
Authors:
F Khan, F; Cotter, O; Kennedy, B; Clair, J; O’Connor, B; Collins, J; Curran, D; O’Connor, T
Publisher:
Irish Medical Journal (IMJ)
Journal:
Irish Medical Journal
Issue Date:
Dec-2013
URI:
http://hdl.handle.net/10147/307036
Abstract:
We analyzed positive QuantiFERON (QFT) assays, performed between July 2009 and April 2011 in the Mercy University Hospital, Cork, Ireland, which included, 94 patients with latent tuberculosis (LTBI) and 35 patients with active tuberculosis. There was no difference in the intensity of response between patients with LTBI and active tuberculosis (p=0.1589). In patients with LTBI, there were no correlations between age (p=0.353), sex (p=0.476), smoking (p=0.323), contact (p=0.612), Mantoux response (p=0.055), Irish nationality (p=0.768), previous BCG vaccination (p=0.504), WCC (p=0.187), lymphocyte count (p=0.786), neutrophil count (p=0.157) and the intensity of QFT response. Similarly in patients with active TB, there were no correlations between these variables and QFT response. The intensity of QFT response does not help to differentiate active from LTBI. The intensity of QFT response is not influenced by age, sex, smoking, remoteness of contact history, Mantoux response, nationality, CXR abnormalities, BCG vaccination and peripheral lymphocyte count.
Item Type:
Article
Language:
en
Keywords:
TUBERCULOSIS
Local subject classification:
QUANTIFERON (QFT)

Full metadata record

DC FieldValue Language
dc.contributor.authorF Khan, Fen_GB
dc.contributor.authorCotter, Oen_GB
dc.contributor.authorKennedy, Ben_GB
dc.contributor.authorClair, Jen_GB
dc.contributor.authorO’Connor, Ben_GB
dc.contributor.authorCollins, Jen_GB
dc.contributor.authorCurran, Den_GB
dc.contributor.authorO’Connor, Ten_GB
dc.date.accessioned2013-12-18T12:22:10Z-
dc.date.available2013-12-18T12:22:10Z-
dc.date.issued2013-12-
dc.identifier.urihttp://hdl.handle.net/10147/307036-
dc.description.abstractWe analyzed positive QuantiFERON (QFT) assays, performed between July 2009 and April 2011 in the Mercy University Hospital, Cork, Ireland, which included, 94 patients with latent tuberculosis (LTBI) and 35 patients with active tuberculosis. There was no difference in the intensity of response between patients with LTBI and active tuberculosis (p=0.1589). In patients with LTBI, there were no correlations between age (p=0.353), sex (p=0.476), smoking (p=0.323), contact (p=0.612), Mantoux response (p=0.055), Irish nationality (p=0.768), previous BCG vaccination (p=0.504), WCC (p=0.187), lymphocyte count (p=0.786), neutrophil count (p=0.157) and the intensity of QFT response. Similarly in patients with active TB, there were no correlations between these variables and QFT response. The intensity of QFT response does not help to differentiate active from LTBI. The intensity of QFT response is not influenced by age, sex, smoking, remoteness of contact history, Mantoux response, nationality, CXR abnormalities, BCG vaccination and peripheral lymphocyte count.en_GB
dc.language.isoenen
dc.publisherIrish Medical Journal (IMJ)en_GB
dc.subjectTUBERCULOSISen_GB
dc.subject.otherQUANTIFERON (QFT)en_GB
dc.titleThe Intensity of QuantiFERON TB-Gold Response does not Differentiate Active from Latent Tuberculosisen_GB
dc.typeArticleen
dc.identifier.journalIrish Medical Journalen_GB
dc.description.fundingNo fundingen
dc.description.provinceMunsteren
dc.description.peer-reviewpeer-reviewen
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