Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission.
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Authors
Rebolledo, JIgoe, D
O'Donnell, J
Domegan, L
Boland, M
Freyne, B
McNamara, A
Molloy, E
Callaghan, M
Ryan, A
O'Flanagan, D
Affiliation
Health Protection Surveillance Centre, Health Service Executive, Dublin, Ireland.Issue Date
2013-11-11Keywords
INFLUENZAEMERGENCY MEDICINE
INFECTION CONTROL
CHILD HEALTH
Local subject classification
PANDEMIC
Metadata
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Influenza in hospitalized children in Ireland in the pandemic period and the 2010/2011 season: risk factors for paediatric intensive-care-unit admission. 2013:1-10 Epidemiol. Infect.Journal
Epidemiology and infectionDOI
10.1017/S0950268813002732PubMed ID
24229618Abstract
SUMMARY Influenza causes significant morbidity and mortality in children. This study's objectives were to describe influenza A(H1N1)pdm09 during the pandemic, to compare it with circulating influenza in 2010/2011, and to identify risk factors for severe influenza defined as requiring admission to a paediatric intensive care unit (PICU). Children hospitalized with influenza during the pandemic were older, and more likely to have received antiviral therapy than children hospitalized during the 2010/2011 season. In 2010/2011, only one child admitted to a PICU with underlying medical conditions had been vaccinated. The risk of severe illness in the pandemic was higher in females and those with underlying conditions. In 2010/2011, infection with influenza A(H1N1)pdm09 compared to other influenza viruses was a significant risk factor for severe disease. An incremental relationship was found between the number of underlying conditions and PICU admission. These findings highlight the importance of improving low vaccination uptake and increasing the use of antivirals in vulnerable children.Item Type
ArticleLanguage
enISSN
1469-4409ae974a485f413a2113503eed53cd6c53
10.1017/S0950268813002732