Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

Hdl Handle:
http://hdl.handle.net/10147/305319
Title:
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Authors:
Eccles, Suzanne A; Aboagye, Eric O; Ali, Simak; Anderson, Annie S; Armes, Jo; Berditchevski, Fedor; Blaydes, Jeremy P; Brennan, Keith; Brown, Nicola J; Bryant, Helen E; Bundred, Nigel J; Burchell, Joy M; Campbell, Anna M; Carroll, Jason S; Clarke, Robert B; Coles, Charlotte E; Cook, Gary JR; Cox, Angela; Curtin, Nicola J; Dekker, Lodewijk V; dos Santos Silva, Isabel; Duffy, Stephen W; Easton, Douglas F; Eccles, Diana M; Edwards, Dylan R; Edwards, Joanne; Evans, D G; Fenlon, Deborah F; Flanagan, James M; Foster, Claire; Gallagher, William M; Garcia-Closas, Montserrat; Gee, Julia M W; Gescher, Andy J; Goh, Vicky; Groves, Ashley M; Harvey, Amanda J; Harvie, Michelle; Hennessy, Bryan T; Hiscox, Stephen; Holen, Ingunn; Howell, Sacha J; Howell, Anthony; Hubbard, Gill; Hulbert-Williams, Nick; Hunter, Myra S; Jasani, Bharat; Jones, Louise J; Key, Timothy J; Kirwan, Cliona C; Kong, Anthony; Kunkler, Ian H; Langdon, Simon P; Leach, Martin O; Mann, David J; Marshall, John F; Martin, Lesley A; Martin, Stewart G; Macdougall, Jennifer E; Miles, David W; Miller, William R; Morris, Joanna R; Moss, Sue M; Mullan, Paul; Natrajan, Rachel; O’Connor, James PB; O’Connor, Rosemary; Palmieri, Carlo; Pharoah, Paul D P; Rakha, Emad A; Reed, Elizabeth; Robinson, Simon P; Sahai, Erik; Saxton, John M; Schmid, Peter; Smalley, Matthew J; Speirs, Valerie; Stein, Robert; Stingl, John; Streuli, Charles H; Tutt, Andrew N J; Velikova, Galina; Walker, Rosemary A; Watson, Christine J; Williams, Kaye J; Young, Leonie S; Thompson, Alastair M
Citation:
Breast Cancer Research. 2013 Oct 01;15(5):R92
Issue Date:
1-Oct-2013
URI:
http://dx.doi.org/10.1186/bcr3493; http://hdl.handle.net/10147/305319
Abstract:
Abstract Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.
Item Type:
Article
Language:
en
Keywords:
CANCER; RESEARCH; BREAST CANCER
Sponsors:
SAE acknowledges support from the NIHR RM/ICR Biomedical Research Centre, ICR and Cancer Research UK. AMT acknowledges support from Breast Cancer Campaign, Breakthrough Breast Cancer and CR-UK.

Full metadata record

DC FieldValue Language
dc.contributor.authorEccles, Suzanne Aen_GB
dc.contributor.authorAboagye, Eric Oen_GB
dc.contributor.authorAli, Simaken_GB
dc.contributor.authorAnderson, Annie Sen_GB
dc.contributor.authorArmes, Joen_GB
dc.contributor.authorBerditchevski, Fedoren_GB
dc.contributor.authorBlaydes, Jeremy Pen_GB
dc.contributor.authorBrennan, Keithen_GB
dc.contributor.authorBrown, Nicola Jen_GB
dc.contributor.authorBryant, Helen Een_GB
dc.contributor.authorBundred, Nigel Jen_GB
dc.contributor.authorBurchell, Joy Men_GB
dc.contributor.authorCampbell, Anna Men_GB
dc.contributor.authorCarroll, Jason Sen_GB
dc.contributor.authorClarke, Robert Ben_GB
dc.contributor.authorColes, Charlotte Een_GB
dc.contributor.authorCook, Gary JRen_GB
dc.contributor.authorCox, Angelaen_GB
dc.contributor.authorCurtin, Nicola Jen_GB
dc.contributor.authorDekker, Lodewijk Ven_GB
dc.contributor.authordos Santos Silva, Isabelen_GB
dc.contributor.authorDuffy, Stephen Wen_GB
dc.contributor.authorEaston, Douglas Fen_GB
dc.contributor.authorEccles, Diana Men_GB
dc.contributor.authorEdwards, Dylan Ren_GB
dc.contributor.authorEdwards, Joanneen_GB
dc.contributor.authorEvans, D Gen_GB
dc.contributor.authorFenlon, Deborah Fen_GB
dc.contributor.authorFlanagan, James Men_GB
dc.contributor.authorFoster, Claireen_GB
dc.contributor.authorGallagher, William Men_GB
dc.contributor.authorGarcia-Closas, Montserraten_GB
dc.contributor.authorGee, Julia M Wen_GB
dc.contributor.authorGescher, Andy Jen_GB
dc.contributor.authorGoh, Vickyen_GB
dc.contributor.authorGroves, Ashley Men_GB
dc.contributor.authorHarvey, Amanda Jen_GB
dc.contributor.authorHarvie, Michelleen_GB
dc.contributor.authorHennessy, Bryan Ten_GB
dc.contributor.authorHiscox, Stephenen_GB
dc.contributor.authorHolen, Ingunnen_GB
dc.contributor.authorHowell, Sacha Jen_GB
dc.contributor.authorHowell, Anthonyen_GB
dc.contributor.authorHubbard, Gillen_GB
dc.contributor.authorHulbert-Williams, Nicken_GB
dc.contributor.authorHunter, Myra Sen_GB
dc.contributor.authorJasani, Bharaten_GB
dc.contributor.authorJones, Louise Jen_GB
dc.contributor.authorKey, Timothy Jen_GB
dc.contributor.authorKirwan, Cliona Cen_GB
dc.contributor.authorKong, Anthonyen_GB
dc.contributor.authorKunkler, Ian Hen_GB
dc.contributor.authorLangdon, Simon Pen_GB
dc.contributor.authorLeach, Martin Oen_GB
dc.contributor.authorMann, David Jen_GB
dc.contributor.authorMarshall, John Fen_GB
dc.contributor.authorMartin, Lesley Aen_GB
dc.contributor.authorMartin, Stewart Gen_GB
dc.contributor.authorMacdougall, Jennifer Een_GB
dc.contributor.authorMiles, David Wen_GB
dc.contributor.authorMiller, William Ren_GB
dc.contributor.authorMorris, Joanna Ren_GB
dc.contributor.authorMoss, Sue Men_GB
dc.contributor.authorMullan, Paulen_GB
dc.contributor.authorNatrajan, Rachelen_GB
dc.contributor.authorO’Connor, James PBen_GB
dc.contributor.authorO’Connor, Rosemaryen_GB
dc.contributor.authorPalmieri, Carloen_GB
dc.contributor.authorPharoah, Paul D Pen_GB
dc.contributor.authorRakha, Emad Aen_GB
dc.contributor.authorReed, Elizabethen_GB
dc.contributor.authorRobinson, Simon Pen_GB
dc.contributor.authorSahai, Eriken_GB
dc.contributor.authorSaxton, John Men_GB
dc.contributor.authorSchmid, Peteren_GB
dc.contributor.authorSmalley, Matthew Jen_GB
dc.contributor.authorSpeirs, Valerieen_GB
dc.contributor.authorStein, Roberten_GB
dc.contributor.authorStingl, Johnen_GB
dc.contributor.authorStreuli, Charles Hen_GB
dc.contributor.authorTutt, Andrew N Jen_GB
dc.contributor.authorVelikova, Galinaen_GB
dc.contributor.authorWalker, Rosemary Aen_GB
dc.contributor.authorWatson, Christine Jen_GB
dc.contributor.authorWilliams, Kaye Jen_GB
dc.contributor.authorYoung, Leonie Sen_GB
dc.contributor.authorThompson, Alastair Men_GB
dc.date.accessioned2013-11-13T10:38:35Z-
dc.date.available2013-11-13T10:38:35Z-
dc.date.issued2013-10-01-
dc.identifier.citationBreast Cancer Research. 2013 Oct 01;15(5):R92en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/bcr3493-
dc.identifier.urihttp://hdl.handle.net/10147/305319-
dc.description.abstractAbstract Introduction Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.-
dc.description.sponsorshipSAE acknowledges support from the NIHR RM/ICR Biomedical Research Centre, ICR and Cancer Research UK. AMT acknowledges support from Breast Cancer Campaign, Breakthrough Breast Cancer and CR-UK.en_GB
dc.language.isoenen
dc.subjectCANCERen_GB
dc.subjectRESEARCHen_GB
dc.subjectBREAST CANCERen_GB
dc.titleCritical research gaps and translational priorities for the successful prevention and treatment of breast canceren_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderSuzanne A Eccles et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-11-13T10:28:08Z-
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