An experimental investigation of the hemodynamic variations due to aplastic vessels within three-dimensional phantom models of the Circle of Willis.

Hdl Handle:
http://hdl.handle.net/10147/304765
Title:
An experimental investigation of the hemodynamic variations due to aplastic vessels within three-dimensional phantom models of the Circle of Willis.
Authors:
Fahy, Paul; McCarthy, Peter; Sultan, Sherif; Hynes, Niamh; Delassus, Patrick; Morris, Liam
Affiliation:
Galway Medical Technologies Centre (GMedTech), Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland.
Citation:
An Experimental Investigation of the Hemodynamic Variations Due to Aplastic Vessels Within Three-Dimensional Phantom Models of the Circle of Willis. 2013: Ann Biomed Eng
Publisher:
Annals of biomedical engineering
Journal:
Annals of biomedical engineering
Issue Date:
10-Sep-2013
URI:
http://hdl.handle.net/10147/304765
DOI:
10.1007/s10439-013-0905-4
PubMed ID:
24018609
Abstract:
A complete circle of Willis (CoW) is found in approximately 30-50% of the population. Anatomical variations, such as absent or surgically clamped vessels, can result in undesirable flow patterns. These can affect the brain's ability to maintain cerebral perfusion and the formation of cerebral aneurysms. An experimental test system was developed to simulate cerebral physiological conditions through three flexible 3D patient-specific models of complete and incomplete CoW geometries. Flow visualizations were performed with isobaric dyes and the mapped dye streamlines were tracked throughout the models. Three to seven flow impact locations were observed for all configurations, corresponding to known sites for aneurysmal formation. Uni and bi-directional cross-flows occurred along the communicating arteries. The greatest shunting of flow occurred for a missing pre-communicating anterior (A1) and posterior (P1) cerebral arteries. The anterior cerebral arteries had the greatest reduction (15-37%) in efferent flow rates for missing either a unilateral A1 or bilateral P1 segments. The bi-directional cross-flows, with multiple afferent flow mixing, observed along the communicating arteries may explain the propensity of aneurysm formation at these sites. Reductions in efferent flow rates due to aplastic vessel configurations may affect normal brain function.
Item Type:
Article
Language:
en
Keywords:
BRAIN DISORDERS
ISSN:
1573-9686

Full metadata record

DC FieldValue Language
dc.contributor.authorFahy, Paulen_GB
dc.contributor.authorMcCarthy, Peteren_GB
dc.contributor.authorSultan, Sherifen_GB
dc.contributor.authorHynes, Niamhen_GB
dc.contributor.authorDelassus, Patricken_GB
dc.contributor.authorMorris, Liamen_GB
dc.date.accessioned2013-10-30T12:01:36Z-
dc.date.available2013-10-30T12:01:36Z-
dc.date.issued2013-09-10-
dc.identifier.citationAn Experimental Investigation of the Hemodynamic Variations Due to Aplastic Vessels Within Three-Dimensional Phantom Models of the Circle of Willis. 2013: Ann Biomed Engen_GB
dc.identifier.issn1573-9686-
dc.identifier.pmid24018609-
dc.identifier.doi10.1007/s10439-013-0905-4-
dc.identifier.urihttp://hdl.handle.net/10147/304765-
dc.description.abstractA complete circle of Willis (CoW) is found in approximately 30-50% of the population. Anatomical variations, such as absent or surgically clamped vessels, can result in undesirable flow patterns. These can affect the brain's ability to maintain cerebral perfusion and the formation of cerebral aneurysms. An experimental test system was developed to simulate cerebral physiological conditions through three flexible 3D patient-specific models of complete and incomplete CoW geometries. Flow visualizations were performed with isobaric dyes and the mapped dye streamlines were tracked throughout the models. Three to seven flow impact locations were observed for all configurations, corresponding to known sites for aneurysmal formation. Uni and bi-directional cross-flows occurred along the communicating arteries. The greatest shunting of flow occurred for a missing pre-communicating anterior (A1) and posterior (P1) cerebral arteries. The anterior cerebral arteries had the greatest reduction (15-37%) in efferent flow rates for missing either a unilateral A1 or bilateral P1 segments. The bi-directional cross-flows, with multiple afferent flow mixing, observed along the communicating arteries may explain the propensity of aneurysm formation at these sites. Reductions in efferent flow rates due to aplastic vessel configurations may affect normal brain function.en_GB
dc.languageENG-
dc.language.isoenen
dc.publisherAnnals of biomedical engineeringen_GB
dc.rightsArchived with thanks to Annals of biomedical engineeringen_GB
dc.subjectBRAIN DISORDERSen_GB
dc.titleAn experimental investigation of the hemodynamic variations due to aplastic vessels within three-dimensional phantom models of the Circle of Willis.en_GB
dc.typeArticleen
dc.contributor.departmentGalway Medical Technologies Centre (GMedTech), Department of Mechanical and Industrial Engineering, Galway Mayo Institute of Technology, Galway, Ireland.en_GB
dc.identifier.journalAnnals of biomedical engineeringen_GB
dc.description.fundingNo fundingen
dc.description.provinceConnachten
dc.description.peer-reviewpeer-reviewen
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