A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations.

Hdl Handle:
http://hdl.handle.net/10147/304764
Title:
A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations.
Authors:
Creane, Arthur; Maher, Eoghan; Sultan, Sherif; Hynes, Niamh; Kelly, Daniel J; Lally, Caitríona
Affiliation:
School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland.
Citation:
A remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations. 2012, 11 (6):869-82 Biomech Model Mechanobiol
Journal:
Biomechanics and modeling in mechanobiology
Issue Date:
Jul-2012
URI:
http://hdl.handle.net/10147/304764
DOI:
10.1007/s10237-011-0358-3
PubMed ID:
22086167
Abstract:
Many soft biological tissues contain collagen fibres, which act as major load bearing constituents. The orientation and the dispersion of these fibres influence the macroscopic mechanical properties of the tissue and are therefore of importance in several areas of research including constitutive model development, tissue engineering and mechanobiology. Qualitative comparisons between these fibre architectures can be made using vector plots of mean orientations and contour plots of fibre dispersion but quantitative comparison cannot be achieved using these methods. We propose a 'remodelling metric' between two angular fibre distributions, which represents the mean rotational effort required to transform one into the other. It is an adaptation of the earth mover's distance, a similarity measure between two histograms/signatures used in image analysis, which represents the minimal cost of transforming one distribution into the other by moving distribution mass around. In this paper, its utility is demonstrated by considering the change in fibre architecture during a period of plaque growth in finite element models of the carotid bifurcation. The fibre architecture is predicted using a strain-based remodelling algorithm. We investigate the remodelling metric's potential as a clinical indicator of plaque vulnerability by comparing results between symptomatic and asymptomatic carotid bifurcations. Fibre remodelling was found to occur at regions of plaque burden. As plaque thickness increased, so did the remodelling metric. A measure of the total predicted fibre remodelling during plaque growth, TRM, was found to be higher in the symptomatic group than in the asymptomatic group. Furthermore, a measure of the total fibre remodelling per plaque size, TRM/TPB, was found to be significantly higher in the symptomatic vessels. The remodelling metric may prove to be a useful tool in other soft tissues and engineered scaffolds where fibre adaptation is also present.
Item Type:
Article
Language:
en
Description:
Many soft biological tissues contain collagen fibres, which act as major load bearing constituents. The orientation and the dispersion of these fibres influence the macroscopic mechanical properties of the tissue and are therefore of importance in several areas of research including constitutive model development, tissue engineering and mechanobiology. Qualitative comparisons between these fibre architectures can be made using vector plots of mean orientations and contour plots of fibre dispersion but quantitative comparison cannot be achieved using these methods. We propose a 'remodelling metric' between two angular fibre distributions, which represents the mean rotational effort required to transform one into the other. It is an adaptation of the earth mover's distance, a similarity measure between two histograms/signatures used in image analysis, which represents the minimal cost of transforming one distribution into the other by moving distribution mass around. In this paper, its utility is demonstrated by considering the change in fibre architecture during a period of plaque growth in finite element models of the carotid bifurcation. The fibre architecture is predicted using a strain-based remodelling algorithm. We investigate the remodelling metric's potential as a clinical indicator of plaque vulnerability by comparing results between symptomatic and asymptomatic carotid bifurcations. Fibre remodelling was found to occur at regions of plaque burden. As plaque thickness increased, so did the remodelling metric. A measure of the total predicted fibre remodelling during plaque growth, TRM, was found to be higher in the symptomatic group than in the asymptomatic group. Furthermore, a measure of the total fibre remodelling per plaque size, TRM/TPB, was found to be significantly higher in the symptomatic vessels. The remodelling metric may prove to be a useful tool in other soft tissues and engineered scaffolds where fibre adaptation is also present.
MeSH:
Biomechanics; Carotid Arteries; Carotid Stenosis; Fibrillar Collagens; Health; Humans; Models, Cardiovascular
ISSN:
1617-7940

Full metadata record

DC FieldValue Language
dc.contributor.authorCreane, Arthuren_GB
dc.contributor.authorMaher, Eoghanen_GB
dc.contributor.authorSultan, Sherifen_GB
dc.contributor.authorHynes, Niamhen_GB
dc.contributor.authorKelly, Daniel Jen_GB
dc.contributor.authorLally, Caitríonaen_GB
dc.date.accessioned2013-10-30T11:49:40Z-
dc.date.available2013-10-30T11:49:40Z-
dc.date.issued2012-07-
dc.identifier.citationA remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations. 2012, 11 (6):869-82 Biomech Model Mechanobiolen_GB
dc.identifier.issn1617-7940-
dc.identifier.pmid22086167-
dc.identifier.doi10.1007/s10237-011-0358-3-
dc.identifier.urihttp://hdl.handle.net/10147/304764-
dc.descriptionMany soft biological tissues contain collagen fibres, which act as major load bearing constituents. The orientation and the dispersion of these fibres influence the macroscopic mechanical properties of the tissue and are therefore of importance in several areas of research including constitutive model development, tissue engineering and mechanobiology. Qualitative comparisons between these fibre architectures can be made using vector plots of mean orientations and contour plots of fibre dispersion but quantitative comparison cannot be achieved using these methods. We propose a 'remodelling metric' between two angular fibre distributions, which represents the mean rotational effort required to transform one into the other. It is an adaptation of the earth mover's distance, a similarity measure between two histograms/signatures used in image analysis, which represents the minimal cost of transforming one distribution into the other by moving distribution mass around. In this paper, its utility is demonstrated by considering the change in fibre architecture during a period of plaque growth in finite element models of the carotid bifurcation. The fibre architecture is predicted using a strain-based remodelling algorithm. We investigate the remodelling metric's potential as a clinical indicator of plaque vulnerability by comparing results between symptomatic and asymptomatic carotid bifurcations. Fibre remodelling was found to occur at regions of plaque burden. As plaque thickness increased, so did the remodelling metric. A measure of the total predicted fibre remodelling during plaque growth, TRM, was found to be higher in the symptomatic group than in the asymptomatic group. Furthermore, a measure of the total fibre remodelling per plaque size, TRM/TPB, was found to be significantly higher in the symptomatic vessels. The remodelling metric may prove to be a useful tool in other soft tissues and engineered scaffolds where fibre adaptation is also present.en_GB
dc.description.abstractMany soft biological tissues contain collagen fibres, which act as major load bearing constituents. The orientation and the dispersion of these fibres influence the macroscopic mechanical properties of the tissue and are therefore of importance in several areas of research including constitutive model development, tissue engineering and mechanobiology. Qualitative comparisons between these fibre architectures can be made using vector plots of mean orientations and contour plots of fibre dispersion but quantitative comparison cannot be achieved using these methods. We propose a 'remodelling metric' between two angular fibre distributions, which represents the mean rotational effort required to transform one into the other. It is an adaptation of the earth mover's distance, a similarity measure between two histograms/signatures used in image analysis, which represents the minimal cost of transforming one distribution into the other by moving distribution mass around. In this paper, its utility is demonstrated by considering the change in fibre architecture during a period of plaque growth in finite element models of the carotid bifurcation. The fibre architecture is predicted using a strain-based remodelling algorithm. We investigate the remodelling metric's potential as a clinical indicator of plaque vulnerability by comparing results between symptomatic and asymptomatic carotid bifurcations. Fibre remodelling was found to occur at regions of plaque burden. As plaque thickness increased, so did the remodelling metric. A measure of the total predicted fibre remodelling during plaque growth, TRM, was found to be higher in the symptomatic group than in the asymptomatic group. Furthermore, a measure of the total fibre remodelling per plaque size, TRM/TPB, was found to be significantly higher in the symptomatic vessels. The remodelling metric may prove to be a useful tool in other soft tissues and engineered scaffolds where fibre adaptation is also present.-
dc.language.isoenen
dc.rightsArchived with thanks to Biomechanics and modeling in mechanobiologyen_GB
dc.subject.meshBiomechanics-
dc.subject.meshCarotid Arteries-
dc.subject.meshCarotid Stenosis-
dc.subject.meshFibrillar Collagens-
dc.subject.meshHealth-
dc.subject.meshHumans-
dc.subject.meshModels, Cardiovascular-
dc.titleA remodelling metric for angular fibre distributions and its application to diseased carotid bifurcations.en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland.en_GB
dc.identifier.journalBiomechanics and modeling in mechanobiologyen_GB

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