Cardiovascular disease: primary prevention, disease modulation and regenerative therapy.

Hdl Handle:
http://hdl.handle.net/10147/304763
Title:
Cardiovascular disease: primary prevention, disease modulation and regenerative therapy.
Authors:
Sultan, Sherif; Hynes, Niamh
Affiliation:
Department of Vascular and Endovascular Surgery, Western Vascular Institute, University College Hospital Galway, Ireland. sherif.sultan@hse.ie
Citation:
Cardiovascular disease: primary prevention, disease modulation and regenerative therapy. 2012, 20 (5):243-50 Vascular
Publisher:
Vascular
Journal:
Vascular
Issue Date:
Oct-2012
URI:
http://hdl.handle.net/10147/304763
DOI:
10.1258/vasc.2012.ra0062
PubMed ID:
23019607
Abstract:
Cardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific nutrients, it is feasible to accelerate cell repair and optimize mitochondrial function, thereby achieving cardiovascular cure. We performed a comprehensive review of PubMed, EMBASE and Cochrane Review databases for articles relating to cardiovascular regenerative medicine, nutrigenomics and primary prevention, with the aim of harmonizing their roles within contemporary clinical practice. We searched in particular for large-scale randomized controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular regenerative programs, such as nitric oxide and glucose metabolism. Scientific research on 'cardiovascular-free' centenarians delineated that low sugar and low insulin are consistent findings. As we age, our insulin level increases. Those who can decelerate the rapidity of this process are prompting their cardiovascular rejuvenation. It is beginning to dawn on some clinicians that contemporary treatments are not only failing to impact on our most prevalent diseases, but they may be causing more damage than good. Primary prevention programs are crucial elements for a better outcome. Cardiovascular primary prevention and regeneration programs have enhanced clinical efficacy and quality of life and complement our conventional endovascular practice.
Item Type:
Article
Language:
en
MeSH:
Cardiovascular Diseases; Humans; Myocardium; Primary Prevention; Recovery of Function; Regeneration; Regenerative Medicine; Treatment Outcome
ISSN:
1708-5381

Full metadata record

DC FieldValue Language
dc.contributor.authorSultan, Sherifen_GB
dc.contributor.authorHynes, Niamhen_GB
dc.date.accessioned2013-10-30T11:49:16Z-
dc.date.available2013-10-30T11:49:16Z-
dc.date.issued2012-10-
dc.identifier.citationCardiovascular disease: primary prevention, disease modulation and regenerative therapy. 2012, 20 (5):243-50 Vascularen_GB
dc.identifier.issn1708-5381-
dc.identifier.pmid23019607-
dc.identifier.doi10.1258/vasc.2012.ra0062-
dc.identifier.urihttp://hdl.handle.net/10147/304763-
dc.description.abstractCardiovascular primary prevention and regeneration programs are the contemporary frontiers in functional metabolic vascular medicine. This novel science perspective harnesses our inherent ability to modulate the interface between specialized gene receptors and bioavailable nutrients in what is labeled as the nutrient-gene interaction. By mimicking a natural process through the conveyance of highly absorbable receptor specific nutrients, it is feasible to accelerate cell repair and optimize mitochondrial function, thereby achieving cardiovascular cure. We performed a comprehensive review of PubMed, EMBASE and Cochrane Review databases for articles relating to cardiovascular regenerative medicine, nutrigenomics and primary prevention, with the aim of harmonizing their roles within contemporary clinical practice. We searched in particular for large-scale randomized controlled trials on contemporary cardiovascular pharmacotherapies and their specific adverse effects on metabolic pathways which feature prominently in cardiovascular regenerative programs, such as nitric oxide and glucose metabolism. Scientific research on 'cardiovascular-free' centenarians delineated that low sugar and low insulin are consistent findings. As we age, our insulin level increases. Those who can decelerate the rapidity of this process are prompting their cardiovascular rejuvenation. It is beginning to dawn on some clinicians that contemporary treatments are not only failing to impact on our most prevalent diseases, but they may be causing more damage than good. Primary prevention programs are crucial elements for a better outcome. Cardiovascular primary prevention and regeneration programs have enhanced clinical efficacy and quality of life and complement our conventional endovascular practice.en_GB
dc.language.isoenen
dc.publisherVascularen_GB
dc.rightsArchived with thanks to Vascularen_GB
dc.subject.meshCardiovascular Diseases-
dc.subject.meshHumans-
dc.subject.meshMyocardium-
dc.subject.meshPrimary Prevention-
dc.subject.meshRecovery of Function-
dc.subject.meshRegeneration-
dc.subject.meshRegenerative Medicine-
dc.subject.meshTreatment Outcome-
dc.titleCardiovascular disease: primary prevention, disease modulation and regenerative therapy.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Vascular and Endovascular Surgery, Western Vascular Institute, University College Hospital Galway, Ireland. sherif.sultan@hse.ieen_GB
dc.identifier.journalVascularen_GB
dc.description.fundingNo fundingen
dc.description.provinceConnachten
dc.description.peer-reviewpeer-reviewen
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