Prediction of fibre architecture and adaptation in diseased carotid bifurcations.

Hdl Handle:
http://hdl.handle.net/10147/304746
Title:
Prediction of fibre architecture and adaptation in diseased carotid bifurcations.
Authors:
Creane, Arthur; Maher, Eoghan; Sultan, Sherif; Hynes, Niamh; Kelly, Daniel J; Lally, Caitríona
Affiliation:
School of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland.
Citation:
Prediction of fibre architecture and adaptation in diseased carotid bifurcations. 2011, 10 (6):831-43 Biomech Model Mechanobiol
Journal:
Biomechanics and modeling in mechanobiology
Issue Date:
Dec-2011
URI:
http://hdl.handle.net/10147/304746
DOI:
10.1007/s10237-010-0277-8
PubMed ID:
21161562
Abstract:
Many studies have used patient-specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. In complex geometries, few studies have incorporated the anisotropic material response of arterial tissue. This paper presents a fibre remodelling algorithm to predict the fibre architecture, and thus anisotropic material response in four patient-specific models of the carotid bifurcation. The change in fibre architecture during disease progression and its affect on the stress environment in the plaque were predicted. The mean fibre directions were assumed to lie at an angle between the two positive principal strain directions. The angle and the degree of dispersion were assumed to depend on the ratio of principal strain values. Results were compared with experimental observations and other numerical studies. In non-branching regions of each model, the typical double helix arterial fibre pattern was predicted while at the bifurcation and in regions of plaque burden, more complex fibre architectures were found. The predicted change in fibre architecture in the arterial tissue during plaque progression was found to alter the stress environment in the plaque. This suggests that the specimen-specific anisotropic response of the tissue should be taken into account to accurately predict stresses in the plaque. Since determination of the fibre architecture in vivo is a difficult task, the system presented here provides a useful method of estimating the fibre architecture in complex arterial geometries.
Item Type:
Article
Language:
en
Description:
Many studies have used patient-specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. In complex geometries, few studies have incorporated the anisotropic material response of arterial tissue. This paper presents a fibre remodelling algorithm to predict the fibre architecture, and thus anisotropic material response in four patient-specific models of the carotid bifurcation. The change in fibre architecture during disease progression and its affect on the stress environment in the plaque were predicted. The mean fibre directions were assumed to lie at an angle between the two positive principal strain directions. The angle and the degree of dispersion were assumed to depend on the ratio of principal strain values. Results were compared with experimental observations and other numerical studies. In non-branching regions of each model, the typical double helix arterial fibre pattern was predicted while at the bifurcation and in regions of plaque burden, more complex fibre architectures were found. The predicted change in fibre architecture in the arterial tissue during plaque progression was found to alter the stress environment in the plaque. This suggests that the specimen-specific anisotropic response of the tissue should be taken into account to accurately predict stresses in the plaque. Since determination of the fibre architecture in vivo is a difficult task, the system presented here provides a useful method of estimating the fibre architecture in complex arterial geometries.
MeSH:
Adaptation, Physiological; Carotid Arteries; Coronary Stenosis; Humans; Models, Cardiovascular
ISSN:
1617-7940

Full metadata record

DC FieldValue Language
dc.contributor.authorCreane, Arthuren_GB
dc.contributor.authorMaher, Eoghanen_GB
dc.contributor.authorSultan, Sherifen_GB
dc.contributor.authorHynes, Niamhen_GB
dc.contributor.authorKelly, Daniel Jen_GB
dc.contributor.authorLally, Caitríonaen_GB
dc.date.accessioned2013-10-30T11:50:09Z-
dc.date.available2013-10-30T11:50:09Z-
dc.date.issued2011-12-
dc.identifier.citationPrediction of fibre architecture and adaptation in diseased carotid bifurcations. 2011, 10 (6):831-43 Biomech Model Mechanobiolen_GB
dc.identifier.issn1617-7940-
dc.identifier.pmid21161562-
dc.identifier.doi10.1007/s10237-010-0277-8-
dc.identifier.urihttp://hdl.handle.net/10147/304746-
dc.descriptionMany studies have used patient-specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. In complex geometries, few studies have incorporated the anisotropic material response of arterial tissue. This paper presents a fibre remodelling algorithm to predict the fibre architecture, and thus anisotropic material response in four patient-specific models of the carotid bifurcation. The change in fibre architecture during disease progression and its affect on the stress environment in the plaque were predicted. The mean fibre directions were assumed to lie at an angle between the two positive principal strain directions. The angle and the degree of dispersion were assumed to depend on the ratio of principal strain values. Results were compared with experimental observations and other numerical studies. In non-branching regions of each model, the typical double helix arterial fibre pattern was predicted while at the bifurcation and in regions of plaque burden, more complex fibre architectures were found. The predicted change in fibre architecture in the arterial tissue during plaque progression was found to alter the stress environment in the plaque. This suggests that the specimen-specific anisotropic response of the tissue should be taken into account to accurately predict stresses in the plaque. Since determination of the fibre architecture in vivo is a difficult task, the system presented here provides a useful method of estimating the fibre architecture in complex arterial geometries.en_GB
dc.description.abstractMany studies have used patient-specific finite element models to estimate the stress environment in atherosclerotic plaques, attempting to correlate the magnitude of stress to plaque vulnerability. In complex geometries, few studies have incorporated the anisotropic material response of arterial tissue. This paper presents a fibre remodelling algorithm to predict the fibre architecture, and thus anisotropic material response in four patient-specific models of the carotid bifurcation. The change in fibre architecture during disease progression and its affect on the stress environment in the plaque were predicted. The mean fibre directions were assumed to lie at an angle between the two positive principal strain directions. The angle and the degree of dispersion were assumed to depend on the ratio of principal strain values. Results were compared with experimental observations and other numerical studies. In non-branching regions of each model, the typical double helix arterial fibre pattern was predicted while at the bifurcation and in regions of plaque burden, more complex fibre architectures were found. The predicted change in fibre architecture in the arterial tissue during plaque progression was found to alter the stress environment in the plaque. This suggests that the specimen-specific anisotropic response of the tissue should be taken into account to accurately predict stresses in the plaque. Since determination of the fibre architecture in vivo is a difficult task, the system presented here provides a useful method of estimating the fibre architecture in complex arterial geometries.-
dc.language.isoenen
dc.rightsArchived with thanks to Biomechanics and modeling in mechanobiologyen_GB
dc.subject.meshAdaptation, Physiological-
dc.subject.meshCarotid Arteries-
dc.subject.meshCoronary Stenosis-
dc.subject.meshHumans-
dc.subject.meshModels, Cardiovascular-
dc.titlePrediction of fibre architecture and adaptation in diseased carotid bifurcations.en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Mechanical and Manufacturing Engineering, Dublin City University, Dublin 9, Ireland.en_GB
dc.identifier.journalBiomechanics and modeling in mechanobiologyen_GB
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