Tensile and compressive properties of fresh human carotid atherosclerotic plaques.

Hdl Handle:
http://hdl.handle.net/10147/304743
Title:
Tensile and compressive properties of fresh human carotid atherosclerotic plaques.
Authors:
Maher, Eoghan; Creane, Arthur; Sultan, Sherif; Hynes, Niamh; Lally, Caitríona; Kelly, Daniel J
Affiliation:
Trinity Centre for Bioengineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.
Citation:
Tensile and compressive properties of fresh human carotid atherosclerotic plaques. 2009, 42 (16):2760-7 J Biomech
Publisher:
Journal of biomechanics
Journal:
Journal of biomechanics
Issue Date:
11-Dec-2009
URI:
http://hdl.handle.net/10147/304743
DOI:
10.1016/j.jbiomech.2009.07.032
PubMed ID:
19766226
Abstract:
Accurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.
Item Type:
Article
Language:
en
Description:
Accurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.
MeSH:
Aged; Carotid Arteries; Carotid Stenosis; Compressive Strength; Computer Simulation; Elastic Modulus; Female; Hardness; Humans; Male; Models, Cardiovascular; Stress, Mechanical; Tensile Strength
ISSN:
1873-2380

Full metadata record

DC FieldValue Language
dc.contributor.authorMaher, Eoghanen_GB
dc.contributor.authorCreane, Arthuren_GB
dc.contributor.authorSultan, Sherifen_GB
dc.contributor.authorHynes, Niamhen_GB
dc.contributor.authorLally, Caitríonaen_GB
dc.contributor.authorKelly, Daniel Jen_GB
dc.date.accessioned2013-10-30T11:48:18Z-
dc.date.available2013-10-30T11:48:18Z-
dc.date.issued2009-12-11-
dc.identifier.citationTensile and compressive properties of fresh human carotid atherosclerotic plaques. 2009, 42 (16):2760-7 J Biomechen_GB
dc.identifier.issn1873-2380-
dc.identifier.pmid19766226-
dc.identifier.doi10.1016/j.jbiomech.2009.07.032-
dc.identifier.urihttp://hdl.handle.net/10147/304743-
dc.descriptionAccurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.en_GB
dc.description.abstractAccurate characterisation of the mechanical properties of human atherosclerotic plaque is important for our understanding of the role of vascular mechanics in the development and treatment of atherosclerosis. The majority of previous studies investigating the mechanical properties of human plaque are based on tests of plaque tissue removed following autopsy. This study aims to characterise the mechanical behaviour of fresh human carotid plaques removed during endarterectomy and tested within 2h. A total of 50 radial compressive and 17 circumferential tensile uniaxial tests were performed on samples taken from 14 carotid plaques. The clinical classification of each plaque, as determined by duplex ultrasound is also reported. Plaques were classified as calcified, mixed or echolucent. Experimental data indicated that plaques were highly inhomogeneous; with variations seen in the mechanical properties of plaque obtained from individual donors and between donors. The mean behaviour of samples for each classification indicated that calcified plaques had the stiffest response, while echolucent plaques were the least stiff. Results also indicated that there may be a difference in behaviour of samples taken from different anatomical locations (common, internal and external carotid), however the large variability indicates that more testing is needed to reach significant conclusions. This work represents a step towards a better understanding of the in vivo mechanical behaviour of human atherosclerotic plaque.-
dc.language.isoenen
dc.publisherJournal of biomechanicsen_GB
dc.rightsArchived with thanks to Journal of biomechanicsen_GB
dc.subject.meshAged-
dc.subject.meshCarotid Arteries-
dc.subject.meshCarotid Stenosis-
dc.subject.meshCompressive Strength-
dc.subject.meshComputer Simulation-
dc.subject.meshElastic Modulus-
dc.subject.meshFemale-
dc.subject.meshHardness-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshModels, Cardiovascular-
dc.subject.meshStress, Mechanical-
dc.subject.meshTensile Strength-
dc.titleTensile and compressive properties of fresh human carotid atherosclerotic plaques.en_GB
dc.typeArticleen
dc.contributor.departmentTrinity Centre for Bioengineering, School of Engineering, Trinity College Dublin, Dublin, Ireland.en_GB
dc.identifier.journalJournal of biomechanicsen_GB

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