Pick 'n' mix: neuropatholgical detection of peri-tumour taupathy.

Hdl Handle:
http://hdl.handle.net/10147/303415
Title:
Pick 'n' mix: neuropatholgical detection of peri-tumour taupathy.
Authors:
Lonergan, Roisin; Carthy, Fiona; Alexander, Michael; Roberts, Kinley; Farrell, Michael; Lynch, Timothy
Affiliation:
Mater Misericordiae Hospital; Neuropathology Department Beaumont Hospital.
Citation:
PICK 'N' MIX: NEUROPATHOLOGICAL DETECTION OF PERI-TUMOUR TAUOPATHY. 2013, 84 (11):e2 J. Neurol. Neurosurg. Psychiatr.
Journal:
Journal of neurology, neurosurgery, and psychiatry
Issue Date:
Nov-2013
URI:
http://hdl.handle.net/10147/303415
DOI:
10.1136/jnnp-2013-306573.85
PubMed ID:
24109071
Abstract:
Radiotherapy is used to treat recurrent oligodendrogliomas, WHO grade 2 tumours. Potential morbitities include steroid-responsive radiation necrosis and radiation leucoencephalopathy, characterised pathologically by reactive astrogliosis, focal necrosis, demyelination, axonal loss, and clinically by progressive subcortical deficits (ataxia, amnesia, incontinence, cognitive decline), with relative sparing of cortical function. Although subcortical features may overlap with neurodegenerative conditions (eg frontotemporal dementia), focal cortical atrophy of FTD causes loss of language function in addition to memory, and specific histopathological features characterise FTD subtypes (eg Pick disease). Association between mitotic disease and tauopathy has not been reported widely, but co-existence is possible. Diagnostic accuracy may guide management.
Item Type:
Article
Keywords:
RADIOTHERAPY; CANCER
Local subject classification:
TUMOUR
ISSN:
1468-330X

Full metadata record

DC FieldValue Language
dc.contributor.authorLonergan, Roisinen_GB
dc.contributor.authorCarthy, Fionaen_GB
dc.contributor.authorAlexander, Michaelen_GB
dc.contributor.authorRoberts, Kinleyen_GB
dc.contributor.authorFarrell, Michaelen_GB
dc.contributor.authorLynch, Timothyen_GB
dc.date.accessioned2013-10-14T15:31:52Z-
dc.date.available2013-10-14T15:31:52Z-
dc.date.issued2013-11-
dc.identifier.citationPICK 'N' MIX: NEUROPATHOLOGICAL DETECTION OF PERI-TUMOUR TAUOPATHY. 2013, 84 (11):e2 J. Neurol. Neurosurg. Psychiatr.en_GB
dc.identifier.issn1468-330X-
dc.identifier.pmid24109071-
dc.identifier.doi10.1136/jnnp-2013-306573.85-
dc.identifier.urihttp://hdl.handle.net/10147/303415-
dc.description.abstractRadiotherapy is used to treat recurrent oligodendrogliomas, WHO grade 2 tumours. Potential morbitities include steroid-responsive radiation necrosis and radiation leucoencephalopathy, characterised pathologically by reactive astrogliosis, focal necrosis, demyelination, axonal loss, and clinically by progressive subcortical deficits (ataxia, amnesia, incontinence, cognitive decline), with relative sparing of cortical function. Although subcortical features may overlap with neurodegenerative conditions (eg frontotemporal dementia), focal cortical atrophy of FTD causes loss of language function in addition to memory, and specific histopathological features characterise FTD subtypes (eg Pick disease). Association between mitotic disease and tauopathy has not been reported widely, but co-existence is possible. Diagnostic accuracy may guide management.en_GB
dc.languageENG-
dc.rightsArchived with thanks to Journal of neurology, neurosurgery, and psychiatryen_GB
dc.subjectRADIOTHERAPYen_GB
dc.subjectCANCERen_GB
dc.subject.otherTUMOURen_GB
dc.titlePick 'n' mix: neuropatholgical detection of peri-tumour taupathy.en_GB
dc.typeArticleen
dc.contributor.departmentMater Misericordiae Hospital; Neuropathology Department Beaumont Hospital.en_GB
dc.identifier.journalJournal of neurology, neurosurgery, and psychiatryen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.