Circulating CD36 Is Reduced in HNF1A-MODY Carriers.

Hdl Handle:
http://hdl.handle.net/10147/303039
Title:
Circulating CD36 Is Reduced in HNF1A-MODY Carriers.
Authors:
Bacon, Siobhan; Kyithar, Ma P; Schmid, Jasmin; Costa Pozza, Andre; Handberg, Aase; Byrne, Maria M
Affiliation:
Department of Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.
Citation:
Circulating CD36 Is Reduced in HNF1A-MODY Carriers. 2013, 8 (9):e74577 PLoS ONE
Journal:
PloS one
Issue Date:
2013
URI:
http://hdl.handle.net/10147/303039
DOI:
10.1371/journal.pone.0074577
PubMed ID:
24069322
Abstract:
Premature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset diabetes of the young (MODY) accounts for approximately 2% of all diabetes, with mutations in the transcription factor; hepatocyte nuclear factor 1 alpha (HNF1A) accounting for the majority of MODY cases. There is somewhat limited data available on the prevalence of macrovascular disease in HNF1A-MODY carriers with diabetes. Marked insulin resistance and the associated dyslipidaemia are not clinical features of HNF1A-MODY carriers. The scavenger protein CD36 has been shown to play a substantial role in the pathogenesis of atherosclerosis, largely through its interaction with oxidised LDL. Higher levels of monocyte CD36 and plasma CD36(sCD36) are seen to cluster with insulin resistance and diabetes. The aim of this study was to determine levels of sCD36 in participants with HNF1A-MODY diabetes and to compare them with unaffected normoglycaemic family members and participants with type 2 diabetes mellitus.
Item Type:
Article
Language:
en
Keywords:
DIABETES
Local subject classification:
DIABETES TYPE 2
ISSN:
1932-6203
Sponsors:
This research was funded in association with the Mater College Foundation and the Metabolic Research Unit. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Full metadata record

DC FieldValue Language
dc.contributor.authorBacon, Siobhanen_GB
dc.contributor.authorKyithar, Ma Pen_GB
dc.contributor.authorSchmid, Jasminen_GB
dc.contributor.authorCosta Pozza, Andreen_GB
dc.contributor.authorHandberg, Aaseen_GB
dc.contributor.authorByrne, Maria Men_GB
dc.date.accessioned2013-10-09T14:49:46Z-
dc.date.available2013-10-09T14:49:46Z-
dc.date.issued2013-
dc.identifier.citationCirculating CD36 Is Reduced in HNF1A-MODY Carriers. 2013, 8 (9):e74577 PLoS ONEen_GB
dc.identifier.issn1932-6203-
dc.identifier.pmid24069322-
dc.identifier.doi10.1371/journal.pone.0074577-
dc.identifier.urihttp://hdl.handle.net/10147/303039-
dc.description.abstractPremature atherosclerosis is a significant cause of morbidity and mortality in type 2 diabetes mellitus. Maturity onset diabetes of the young (MODY) accounts for approximately 2% of all diabetes, with mutations in the transcription factor; hepatocyte nuclear factor 1 alpha (HNF1A) accounting for the majority of MODY cases. There is somewhat limited data available on the prevalence of macrovascular disease in HNF1A-MODY carriers with diabetes. Marked insulin resistance and the associated dyslipidaemia are not clinical features of HNF1A-MODY carriers. The scavenger protein CD36 has been shown to play a substantial role in the pathogenesis of atherosclerosis, largely through its interaction with oxidised LDL. Higher levels of monocyte CD36 and plasma CD36(sCD36) are seen to cluster with insulin resistance and diabetes. The aim of this study was to determine levels of sCD36 in participants with HNF1A-MODY diabetes and to compare them with unaffected normoglycaemic family members and participants with type 2 diabetes mellitus.en_GB
dc.description.sponsorshipThis research was funded in association with the Mater College Foundation and the Metabolic Research Unit. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to PloS oneen_GB
dc.subjectDIABETESen_GB
dc.subject.otherDIABETES TYPE 2en_GB
dc.titleCirculating CD36 Is Reduced in HNF1A-MODY Carriers.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Endocrinology, Mater Misericordiae University Hospital, Dublin, Ireland.en_GB
dc.identifier.journalPloS oneen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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