Dementia in Down's syndrome: an MRI comparison with Alzheimer's disease in the general population

Hdl Handle:
http://hdl.handle.net/10147/302975
Title:
Dementia in Down's syndrome: an MRI comparison with Alzheimer's disease in the general population
Authors:
Mullins, Diane; Daly, Eileen; Simmons, Andrew; Beacher, Felix; Foy, Catherine ML; Lovestone, Simon; Hallahan, Brian; Murphy, Kieran C; Murphy, Declan G
Citation:
Journal of Neurodevelopmental Disorders. 2013 Aug 20;5(1):19
Issue Date:
20-Aug-2013
URI:
http://dx.doi.org/10.1186/1866-1955-5-19; http://hdl.handle.net/10147/302975
Abstract:
Abstract Background Down’s syndrome (DS) is the most common genetic cause of intellectual disability. People with DS are at an increased risk of Alzheimer’s disease (AD) compared to the general population. Neuroimaging studies of AD have focused on medial temporal structures; however, to our knowledge, no in vivo case–control study exists comparing the anatomy of dementia in DS to people with AD in the general population. We therefore compared the in vivo brain anatomy of people with DS and dementia (DS+) to those with AD in the general population. Method Using MRI in 192 adults, we compared the volume of whole brain matter, lateral ventricles, temporal lobes and hippocampus in DS subjects with and without dementia (DS+, DS-), to each other and to three non-DS groups. These included one group of individuals with AD and two groups of controls (each age-matched for their respective DS and general population AD cohorts). Results AD and DS+ subjects showed significant reductions in the volume of the whole brain, hippocampus and temporal lobes and a significant elevation in the volume of the lateral ventricle, compared to their non-demented counterparts. People with DS+ had a smaller reduction in temporal lobe volume compared to individuals with AD. Conclusions DS+ and AD subjects have a significant reduction in volume of the same brain regions. We found preliminary evidence that DS individuals may be more sensitive to tissue loss than others and have less ‘cognitive reserve’.
Item Type:
Article
Language:
en
Keywords:
DOWNS SYNDROME; ALZHEIMER'S DISEASE; DEMENTIA

Full metadata record

DC FieldValue Language
dc.contributor.authorMullins, Dianeen_GB
dc.contributor.authorDaly, Eileenen_GB
dc.contributor.authorSimmons, Andrewen_GB
dc.contributor.authorBeacher, Felixen_GB
dc.contributor.authorFoy, Catherine MLen_GB
dc.contributor.authorLovestone, Simonen_GB
dc.contributor.authorHallahan, Brianen_GB
dc.contributor.authorMurphy, Kieran Cen_GB
dc.contributor.authorMurphy, Declan Gen_GB
dc.date.accessioned2013-10-08T15:40:25Z-
dc.date.available2013-10-08T15:40:25Z-
dc.date.issued2013-08-20-
dc.identifier.citationJournal of Neurodevelopmental Disorders. 2013 Aug 20;5(1):19en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1866-1955-5-19-
dc.identifier.urihttp://hdl.handle.net/10147/302975-
dc.description.abstractAbstract Background Down’s syndrome (DS) is the most common genetic cause of intellectual disability. People with DS are at an increased risk of Alzheimer’s disease (AD) compared to the general population. Neuroimaging studies of AD have focused on medial temporal structures; however, to our knowledge, no in vivo case–control study exists comparing the anatomy of dementia in DS to people with AD in the general population. We therefore compared the in vivo brain anatomy of people with DS and dementia (DS+) to those with AD in the general population. Method Using MRI in 192 adults, we compared the volume of whole brain matter, lateral ventricles, temporal lobes and hippocampus in DS subjects with and without dementia (DS+, DS-), to each other and to three non-DS groups. These included one group of individuals with AD and two groups of controls (each age-matched for their respective DS and general population AD cohorts). Results AD and DS+ subjects showed significant reductions in the volume of the whole brain, hippocampus and temporal lobes and a significant elevation in the volume of the lateral ventricle, compared to their non-demented counterparts. People with DS+ had a smaller reduction in temporal lobe volume compared to individuals with AD. Conclusions DS+ and AD subjects have a significant reduction in volume of the same brain regions. We found preliminary evidence that DS individuals may be more sensitive to tissue loss than others and have less ‘cognitive reserve’.-
dc.language.isoenen
dc.subjectDOWNS SYNDROMEen_GB
dc.subjectALZHEIMER'S DISEASEen_GB
dc.subjectDEMENTIAen_GB
dc.titleDementia in Down's syndrome: an MRI comparison with Alzheimer's disease in the general populationen_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderDiane Mullins et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-10-08T04:07:40Z-
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