Seroprevalence of schistosomiasis and strongyloides infection in HIV-infected patients from endemic areas attending a European infectious diseases clinic

Hdl Handle:
http://hdl.handle.net/10147/302741
Title:
Seroprevalence of schistosomiasis and strongyloides infection in HIV-infected patients from endemic areas attending a European infectious diseases clinic
Authors:
Sadlier, Corinna M; Brown, Aisling; Lambert, John S; Sheehan, Gerard; Mallon, Patrick W G
Citation:
AIDS Research and Therapy. 2013 Sep 08;10(1):23
Issue Date:
8-Sep-2013
URI:
http://dx.doi.org/10.1186/1742-6405-10-23; http://hdl.handle.net/10147/302741
Abstract:
Abstract Background Although the Centres for disease Control and Prevention (CDC) recommends empiric treatment for schistosomiasis and strongyloidiasis (prevalent but treatable parasitic infections) in some refugee groups it is unclear if these guidelines should be extended to non-refugee immigrants from endemic areas. We aimed to assess seroprevalence of, and risk factors for, positive schistosomiasis and strongyloides serology in HIV-infected patients from endemic areas attending a European Infectious Diseases clinic. Methods In a prospective cohort study, HIV-infected patients from helminth endemic areas underwent clinical assessment and blood draw for schistosomiasis and strongyloides serology, routine haematology and inflammatory markers (ESR and CRP). Between-group differences were analyzed by Wilcoxin Signed Rank and Fisher’s t tests as appropriate. Results Ninety HIV-infected patients (mean [standard deviation (SD)] age 34 [6] years, 29% male) were recruited from May 2008 to June 2009. Nine (10%) subjects tested positive for helminth infections. Seven tested positive for schistosomiasis (8%) while two tested positive for strongyloides (2%). Seropositive subjects were more likely to have higher eosinophil counts (mean [SD]) (0.3 [0.3] vs. 0.15 [0.2] x103cells/cm, P = 0.021) with a trend towards lower CD4+ T-cell counts (mean [SD]) (280 [218] vs. 395 [217] cells/mm3, P = 0.08). Conclusion The high prevalence of helminth infections (10%) in asymptomatic HIV infected adults identified in this study supports routine screening of immigrants from helminth endemic areas or with exposure history.
Item Type:
Article
Language:
en
Keywords:
HIV INFECTION; COMMUNICABLE DISEASE

Full metadata record

DC FieldValue Language
dc.contributor.authorSadlier, Corinna Men_GB
dc.contributor.authorBrown, Aislingen_GB
dc.contributor.authorLambert, John Sen_GB
dc.contributor.authorSheehan, Gerarden_GB
dc.contributor.authorMallon, Patrick W Gen_GB
dc.date.accessioned2013-10-04T15:17:07Z-
dc.date.available2013-10-04T15:17:07Z-
dc.date.issued2013-09-08-
dc.identifier.citationAIDS Research and Therapy. 2013 Sep 08;10(1):23en_GB
dc.identifier.urihttp://dx.doi.org/10.1186/1742-6405-10-23-
dc.identifier.urihttp://hdl.handle.net/10147/302741-
dc.description.abstractAbstract Background Although the Centres for disease Control and Prevention (CDC) recommends empiric treatment for schistosomiasis and strongyloidiasis (prevalent but treatable parasitic infections) in some refugee groups it is unclear if these guidelines should be extended to non-refugee immigrants from endemic areas. We aimed to assess seroprevalence of, and risk factors for, positive schistosomiasis and strongyloides serology in HIV-infected patients from endemic areas attending a European Infectious Diseases clinic. Methods In a prospective cohort study, HIV-infected patients from helminth endemic areas underwent clinical assessment and blood draw for schistosomiasis and strongyloides serology, routine haematology and inflammatory markers (ESR and CRP). Between-group differences were analyzed by Wilcoxin Signed Rank and Fisher’s t tests as appropriate. Results Ninety HIV-infected patients (mean [standard deviation (SD)] age 34 [6] years, 29% male) were recruited from May 2008 to June 2009. Nine (10%) subjects tested positive for helminth infections. Seven tested positive for schistosomiasis (8%) while two tested positive for strongyloides (2%). Seropositive subjects were more likely to have higher eosinophil counts (mean [SD]) (0.3 [0.3] vs. 0.15 [0.2] x103cells/cm, P = 0.021) with a trend towards lower CD4+ T-cell counts (mean [SD]) (280 [218] vs. 395 [217] cells/mm3, P = 0.08). Conclusion The high prevalence of helminth infections (10%) in asymptomatic HIV infected adults identified in this study supports routine screening of immigrants from helminth endemic areas or with exposure history.-
dc.language.isoenen
dc.subjectHIV INFECTIONen_GB
dc.subjectCOMMUNICABLE DISEASEen_GB
dc.titleSeroprevalence of schistosomiasis and strongyloides infection in HIV-infected patients from endemic areas attending a European infectious diseases clinicen_GB
dc.typeArticleen
dc.language.rfc3066en-
dc.rights.holderCorinna M Sadlier et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-10-01T20:00:19Z-
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