Hdl Handle:
http://hdl.handle.net/10147/302676
Title:
Measles vaccine: a 27-year follow-up.
Authors:
Ramsay, M E; Moffatt, D; O'Connor, M
Affiliation:
Immunisation Division, PHLS Communicable Disease Surveillance Centre, London.
Citation:
Measles vaccine: a 27-year follow-up. 1994, 112 (2):409-12 Epidemiol. Infect.
Journal:
Epidemiology and infection
Issue Date:
Apr-1994
URI:
http://hdl.handle.net/10147/302676
PubMed ID:
8150015
Abstract:
In 1964, the Medical Research Council undertook a trial of measles vaccine in over 36,000 United Kingdom children; 9577 of whom received live vaccine, 10,625 received inactivated followed by live vaccines, and 16,328 acted as unvaccinated controls. Participants in this study have been followed to determine the long term protection from measles vaccine and follow-up data were available on 4194, 4638 and 274 respectively. During the 5-year period 1986-90, the protective efficacy of live measles vaccine has remained high at 87%, but the 95% confidence interval was wide (-43 to 99%) due to the small numbers of cases. Between 1976 and 1990, however, the overall efficacy of the live vaccine was 92% (95% confidence interval 86 to 95%) and there was no evidence of a decline in efficacy (P = 0.13) over the 15-year period. This study suggests that the protection from live measles vaccine persists for up to 27 years after vaccination, and that no change in the current United Kingdom measles immunization policy should be made on the grounds of waning immunity.
Item Type:
Article
Language:
en
Keywords:
MEASLES; VACCINES
MeSH:
Child, Preschool; Confidence Intervals; Follow-Up Studies; Great Britain; Health Policy; Humans; Immunization Schedule; Immunization, Secondary; Incidence; Infant; Measles; Measles Vaccine; Population Surveillance; Treatment Failure; Vaccines, Attenuated; Vaccines, Inactivated
ISSN:
0950-2688

Full metadata record

DC FieldValue Language
dc.contributor.authorRamsay, M Een_GB
dc.contributor.authorMoffatt, Den_GB
dc.contributor.authorO'Connor, Men_GB
dc.date.accessioned2013-10-03T15:12:26Z-
dc.date.available2013-10-03T15:12:26Z-
dc.date.issued1994-04-
dc.identifier.citationMeasles vaccine: a 27-year follow-up. 1994, 112 (2):409-12 Epidemiol. Infect.en_GB
dc.identifier.issn0950-2688-
dc.identifier.pmid8150015-
dc.identifier.urihttp://hdl.handle.net/10147/302676-
dc.description.abstractIn 1964, the Medical Research Council undertook a trial of measles vaccine in over 36,000 United Kingdom children; 9577 of whom received live vaccine, 10,625 received inactivated followed by live vaccines, and 16,328 acted as unvaccinated controls. Participants in this study have been followed to determine the long term protection from measles vaccine and follow-up data were available on 4194, 4638 and 274 respectively. During the 5-year period 1986-90, the protective efficacy of live measles vaccine has remained high at 87%, but the 95% confidence interval was wide (-43 to 99%) due to the small numbers of cases. Between 1976 and 1990, however, the overall efficacy of the live vaccine was 92% (95% confidence interval 86 to 95%) and there was no evidence of a decline in efficacy (P = 0.13) over the 15-year period. This study suggests that the protection from live measles vaccine persists for up to 27 years after vaccination, and that no change in the current United Kingdom measles immunization policy should be made on the grounds of waning immunity.-
dc.language.isoenen
dc.rightsArchived with thanks to Epidemiology and infectionen_GB
dc.subjectMEASLESen_GB
dc.subjectVACCINESen_GB
dc.subject.meshChild, Preschool-
dc.subject.meshConfidence Intervals-
dc.subject.meshFollow-Up Studies-
dc.subject.meshGreat Britain-
dc.subject.meshHealth Policy-
dc.subject.meshHumans-
dc.subject.meshImmunization Schedule-
dc.subject.meshImmunization, Secondary-
dc.subject.meshIncidence-
dc.subject.meshInfant-
dc.subject.meshMeasles-
dc.subject.meshMeasles Vaccine-
dc.subject.meshPopulation Surveillance-
dc.subject.meshTreatment Failure-
dc.subject.meshVaccines, Attenuated-
dc.subject.meshVaccines, Inactivated-
dc.titleMeasles vaccine: a 27-year follow-up.en_GB
dc.typeArticleen
dc.contributor.departmentImmunisation Division, PHLS Communicable Disease Surveillance Centre, London.en_GB
dc.identifier.journalEpidemiology and infectionen_GB
All Items in Lenus, The Irish Health Repository are protected by copyright, with all rights reserved, unless otherwise indicated.