Detection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer's disease etiology using a novel event-based prospective memory task.

Hdl Handle:
http://hdl.handle.net/10147/302667
Title:
Detection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer's disease etiology using a novel event-based prospective memory task.
Authors:
Blanco-Campal, Alberto; Coen, Robert F; Lawlor, Brian A; Walsh, Joseph B; Burke, Teresa E
Affiliation:
School of Psychology, University College Dublin, Dublin, Ireland. Alberto.Blanco-Campal@hse.ie
Citation:
Detection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer's disease etiology using a novel event-based prospective memory task. 2009, 15 (1):154-9 J Int Neuropsychol Soc
Publisher:
Journal of the International Neuropsychological Society : JINS
Journal:
Journal of the International Neuropsychological Society : JINS
Issue Date:
Jan-2009
URI:
http://hdl.handle.net/10147/302667
DOI:
10.1017/S1355617708090127
PubMed ID:
19128540
Additional Links:
http://www.ncbi.nlm.nih.gov/pubmed/19128540
Abstract:
We investigated the relative discriminatory efficacy of an event-based prospective memory (PM) task, in which specificity of the instructions and perceptual salience of the PM cue were manipulated, compared with two widely used retrospective memory (RM) tests (Rivermead Paragraph Recall Test and CERAD-Word List Test), when detecting mild cognitive impairment of suspected Alzheimer's disease etiology (MCI-AD) (N = 19) from normal controls (NC) (N = 21). Statistical analyses showed high discriminatory capacity of the PM task for detecting MCI-AD. The Non-Specific-Non-Salient condition proved particularly useful in detecting MCI-AD, possibly reflecting the difficulty of the task, requiring more strategic attentional resources to monitor for the PM cue. With a cutoff score of <4/10, the Non-Specific-Non-Salient condition achieved a sensitivity = 84%, and a specificity = 95%, superior to the most discriminative RM test used (CERAD-Total Learning: sensitivity = 83%; specificity = 76%). Results suggest that PM is an early sign of memory failure in MCI-AD and may be a more pronounced deficit than retrospective failure, probably reflecting the greater self-initiated retrieval demands involved in the PM task used. Limitations include the relatively small sample size, and the use of a convenience sample (i.e. memory clinic attenders and healthy active volunteers), reducing the generalizability of the results, which should be regarded as preliminary. (JINS, 2009, 15, 154-159.).
Item Type:
Article
Language:
en
Description:
We investigated the relative discriminatory efficacy of an event-based prospective memory (PM) task, in which specificity of the instructions and perceptual salience of the PM cue were manipulated, compared with two widely used retrospective memory (RM) tests (Rivermead Paragraph Recall Test and CERAD-Word List Test), when detecting mild cognitive impairment of suspected Alzheimer's disease etiology (MCI-AD) (N = 19) from normal controls (NC) (N = 21). Statistical analyses showed high discriminatory capacity of the PM task for detecting MCI-AD. The Non-Specific-Non-Salient condition proved particularly useful in detecting MCI-AD, possibly reflecting the difficulty of the task, requiring more strategic attentional resources to monitor for the PM cue. With a cutoff score of <4/10, the Non-Specific-Non-Salient condition achieved a sensitivity = 84%, and a specificity = 95%, superior to the most discriminative RM test used (CERAD-Total Learning: sensitivity = 83%; specificity = 76%). Results suggest that PM is an early sign of memory failure in MCI-AD and may be a more pronounced deficit than retrospective failure, probably reflecting the greater self-initiated retrieval demands involved in the PM task used. Limitations include the relatively small sample size, and the use of a convenience sample (i.e. memory clinic attenders and healthy active volunteers), reducing the generalizability of the results, which should be regarded as preliminary. (JINS, 2009, 15, 154-159.).
Keywords:
ALZHEIMER'S DISEASE
MeSH:
Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Cues; Female; Humans; Male; Memory; Memory Disorders; Middle Aged; Neuropsychological Tests; Psychomotor Performance
ISSN:
1469-7661

Full metadata record

DC FieldValue Language
dc.contributor.authorBlanco-Campal, Albertoen_GB
dc.contributor.authorCoen, Robert Fen_GB
dc.contributor.authorLawlor, Brian Aen_GB
dc.contributor.authorWalsh, Joseph Ben_GB
dc.contributor.authorBurke, Teresa Een_GB
dc.date.accessioned2013-10-03T14:07:17Z-
dc.date.available2013-10-03T14:07:17Z-
dc.date.issued2009-01-
dc.identifier.citationDetection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer's disease etiology using a novel event-based prospective memory task. 2009, 15 (1):154-9 J Int Neuropsychol Socen_GB
dc.identifier.issn1469-7661-
dc.identifier.pmid19128540-
dc.identifier.doi10.1017/S1355617708090127-
dc.identifier.urihttp://hdl.handle.net/10147/302667-
dc.descriptionWe investigated the relative discriminatory efficacy of an event-based prospective memory (PM) task, in which specificity of the instructions and perceptual salience of the PM cue were manipulated, compared with two widely used retrospective memory (RM) tests (Rivermead Paragraph Recall Test and CERAD-Word List Test), when detecting mild cognitive impairment of suspected Alzheimer's disease etiology (MCI-AD) (N = 19) from normal controls (NC) (N = 21). Statistical analyses showed high discriminatory capacity of the PM task for detecting MCI-AD. The Non-Specific-Non-Salient condition proved particularly useful in detecting MCI-AD, possibly reflecting the difficulty of the task, requiring more strategic attentional resources to monitor for the PM cue. With a cutoff score of <4/10, the Non-Specific-Non-Salient condition achieved a sensitivity = 84%, and a specificity = 95%, superior to the most discriminative RM test used (CERAD-Total Learning: sensitivity = 83%; specificity = 76%). Results suggest that PM is an early sign of memory failure in MCI-AD and may be a more pronounced deficit than retrospective failure, probably reflecting the greater self-initiated retrieval demands involved in the PM task used. Limitations include the relatively small sample size, and the use of a convenience sample (i.e. memory clinic attenders and healthy active volunteers), reducing the generalizability of the results, which should be regarded as preliminary. (JINS, 2009, 15, 154-159.).en_GB
dc.description.abstractWe investigated the relative discriminatory efficacy of an event-based prospective memory (PM) task, in which specificity of the instructions and perceptual salience of the PM cue were manipulated, compared with two widely used retrospective memory (RM) tests (Rivermead Paragraph Recall Test and CERAD-Word List Test), when detecting mild cognitive impairment of suspected Alzheimer's disease etiology (MCI-AD) (N = 19) from normal controls (NC) (N = 21). Statistical analyses showed high discriminatory capacity of the PM task for detecting MCI-AD. The Non-Specific-Non-Salient condition proved particularly useful in detecting MCI-AD, possibly reflecting the difficulty of the task, requiring more strategic attentional resources to monitor for the PM cue. With a cutoff score of <4/10, the Non-Specific-Non-Salient condition achieved a sensitivity = 84%, and a specificity = 95%, superior to the most discriminative RM test used (CERAD-Total Learning: sensitivity = 83%; specificity = 76%). Results suggest that PM is an early sign of memory failure in MCI-AD and may be a more pronounced deficit than retrospective failure, probably reflecting the greater self-initiated retrieval demands involved in the PM task used. Limitations include the relatively small sample size, and the use of a convenience sample (i.e. memory clinic attenders and healthy active volunteers), reducing the generalizability of the results, which should be regarded as preliminary. (JINS, 2009, 15, 154-159.).-
dc.language.isoenen
dc.publisherJournal of the International Neuropsychological Society : JINSen_GB
dc.relation.urlhttp://www.ncbi.nlm.nih.gov/pubmed/19128540en_GB
dc.rightsArchived with thanks to Journal of the International Neuropsychological Society : JINSen_GB
dc.subjectALZHEIMER'S DISEASEen_GB
dc.subject.meshAged-
dc.subject.meshAged, 80 and over-
dc.subject.meshAlzheimer Disease-
dc.subject.meshCognition Disorders-
dc.subject.meshCues-
dc.subject.meshFemale-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMemory-
dc.subject.meshMemory Disorders-
dc.subject.meshMiddle Aged-
dc.subject.meshNeuropsychological Tests-
dc.subject.meshPsychomotor Performance-
dc.titleDetection of prospective memory deficits in mild cognitive impairment of suspected Alzheimer's disease etiology using a novel event-based prospective memory task.en_GB
dc.typeArticleen
dc.contributor.departmentSchool of Psychology, University College Dublin, Dublin, Ireland. Alberto.Blanco-Campal@hse.ieen_GB
dc.identifier.journalJournal of the International Neuropsychological Society : JINSen_GB

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