A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011.

Hdl Handle:
http://hdl.handle.net/10147/302486
Title:
A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011.
Authors:
Fitzgibbon, M M; Gibbons, N; Roycroft, E; Jackson, S; O'Donnell, J; O'Flanagan, D; Rogers, T R
Affiliation:
Irish Mycobacteria Reference Laboratory, St. James Hospital, Dublin, Ireland. MFitzgibbon@STJAMES.IE
Citation:
A snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011. 2013, 18 (3): Euro Surveill.
Journal:
Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletin
Issue Date:
2013
URI:
http://hdl.handle.net/10147/302486
PubMed ID:
23351653
Abstract:
Mycobacterial interspersed repetitive-unit-variable-number tandem repeat typing alone was used to investigate the genetic lineages among 361 Mycobacterium tuberculosis strains circulating in Ireland over a two-year period, 2010 and 2011. The majority of isolates, 63% (229/361), belonged to lineage 4 (Euro-American), while lineages 1 (Indo-Oceanic), 2 (East-Asian) and 3 (East-African–Indian) represented 12% of isolates each (42/361, 45/361, and 45/361, respectively). Sub-lineages Beijing (lineage 2), East-African–Indian (lineage 1) and Delhi/central-Asian (lineage 3) predominated among foreign-born cases, while a higher proportion of Euro-American lineages were identified among cases born in Ireland. Eighteen molecular clusters involving 63 tuberculosis (TB) cases were identified across four sub-lineages of lineage 4. While the mean cluster size was 3.5 TB cases, the largest cluster (involving 12 Irish-born cases) was identified in the Latin American–Mediterranean sub-lineage. Clustering of isolates was higher among Irish-born TB cases (47 of 63 clustered cases), whereas only one cluster (3/63) involved solely foreign-born individuals. Four multidrug-resistant cases identified during this period represented lineages 2 and 4. This study provides the first insight into the structure of the M. tuberculosis population in Ireland.
Item Type:
Article
Language:
en
Keywords:
TUBERCULOSIS; POPULATION HEALTH
MeSH:
Cluster Analysis; DNA, Bacterial; Electrophoresis; Genotyping Techniques; Humans; Ireland; Molecular Epidemiology; Multilocus Sequence Typing; Mycobacterium tuberculosis; Phylogeny; Polymerase Chain Reaction; Population Surveillance; Prevalence; Tandem Repeat Sequences; Tuberculosis
ISSN:
1560-7917

Full metadata record

DC FieldValue Language
dc.contributor.authorFitzgibbon, M Men_GB
dc.contributor.authorGibbons, Nen_GB
dc.contributor.authorRoycroft, Een_GB
dc.contributor.authorJackson, Sen_GB
dc.contributor.authorO'Donnell, Jen_GB
dc.contributor.authorO'Flanagan, Den_GB
dc.contributor.authorRogers, T Ren_GB
dc.date.accessioned2013-09-30T10:10:47Z-
dc.date.available2013-09-30T10:10:47Z-
dc.date.issued2013-
dc.identifier.citationA snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011. 2013, 18 (3): Euro Surveill.en_GB
dc.identifier.issn1560-7917-
dc.identifier.pmid23351653-
dc.identifier.urihttp://hdl.handle.net/10147/302486-
dc.description.abstractMycobacterial interspersed repetitive-unit-variable-number tandem repeat typing alone was used to investigate the genetic lineages among 361 Mycobacterium tuberculosis strains circulating in Ireland over a two-year period, 2010 and 2011. The majority of isolates, 63% (229/361), belonged to lineage 4 (Euro-American), while lineages 1 (Indo-Oceanic), 2 (East-Asian) and 3 (East-African–Indian) represented 12% of isolates each (42/361, 45/361, and 45/361, respectively). Sub-lineages Beijing (lineage 2), East-African–Indian (lineage 1) and Delhi/central-Asian (lineage 3) predominated among foreign-born cases, while a higher proportion of Euro-American lineages were identified among cases born in Ireland. Eighteen molecular clusters involving 63 tuberculosis (TB) cases were identified across four sub-lineages of lineage 4. While the mean cluster size was 3.5 TB cases, the largest cluster (involving 12 Irish-born cases) was identified in the Latin American–Mediterranean sub-lineage. Clustering of isolates was higher among Irish-born TB cases (47 of 63 clustered cases), whereas only one cluster (3/63) involved solely foreign-born individuals. Four multidrug-resistant cases identified during this period represented lineages 2 and 4. This study provides the first insight into the structure of the M. tuberculosis population in Ireland.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Euro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletinen_GB
dc.subjectTUBERCULOSISen_GB
dc.subjectPOPULATION HEALTHen_GB
dc.subject.meshCluster Analysis-
dc.subject.meshDNA, Bacterial-
dc.subject.meshElectrophoresis-
dc.subject.meshGenotyping Techniques-
dc.subject.meshHumans-
dc.subject.meshIreland-
dc.subject.meshMolecular Epidemiology-
dc.subject.meshMultilocus Sequence Typing-
dc.subject.meshMycobacterium tuberculosis-
dc.subject.meshPhylogeny-
dc.subject.meshPolymerase Chain Reaction-
dc.subject.meshPopulation Surveillance-
dc.subject.meshPrevalence-
dc.subject.meshTandem Repeat Sequences-
dc.subject.meshTuberculosis-
dc.titleA snapshot of genetic lineages of Mycobacterium tuberculosis in Ireland over a two-year period, 2010 and 2011.en_GB
dc.typeArticleen
dc.contributor.departmentIrish Mycobacteria Reference Laboratory, St. James Hospital, Dublin, Ireland. MFitzgibbon@STJAMES.IEen_GB
dc.identifier.journalEuro surveillance : bulletin Européen sur les maladies transmissibles = European communicable disease bulletinen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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