Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide.

Hdl Handle:
http://hdl.handle.net/10147/302410
Title:
Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide.
Authors:
Flanagan, Frances; Glackin, Louisa; Slattery, Dubhfeasa M
Affiliation:
Department of Respiratory Medicine, Children's University Hospital, Dublin, Ireland. fraflanagan@gmail.com
Citation:
Successful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide. 2013, 48 (3):303-5 Pediatr. Pulmonol.
Journal:
Pediatric pulmonology
Issue Date:
Mar-2013
URI:
http://hdl.handle.net/10147/302410
DOI:
10.1002/ppul.22583
PubMed ID:
22573417
Abstract:
Idiopathic pulmonary hemosiderosis (IPH), a subtype of diffuse alveolar hemorrhage is a rare condition, first described by Virchow in 1864. Historically, it manifests in children in the first decade of life with the combination of hemoptysis, iron deficiency anemia, and alveolar infiltrates on chest radiograph. More recently, diffuse alveolar hemorrhage has been classified by the absence or presence of pulmonary capillaritis (PC), the latter carrying a potential for a poorer outcome. While systemic corticosteroids remain the first line treatment option, other immune modulators have been trailed including hydroxychloroquine, azathioprine, 6-mercaptopurine, and cyclophosphamide with varying results. Our case demonstrates for the first time, the successful use of intravenous cyclophosphamide in the management of chronic idiopathic PC.
Item Type:
Article
Language:
en
MeSH:
Child; Cyclophosphamide; Hemosiderosis; Humans; Immunosuppressive Agents; Infusions, Intravenous; Lung Diseases; Male
ISSN:
1099-0496

Full metadata record

DC FieldValue Language
dc.contributor.authorFlanagan, Francesen_GB
dc.contributor.authorGlackin, Louisaen_GB
dc.contributor.authorSlattery, Dubhfeasa Men_GB
dc.date.accessioned2013-09-27T11:40:30Z-
dc.date.available2013-09-27T11:40:30Z-
dc.date.issued2013-03-
dc.identifier.citationSuccessful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide. 2013, 48 (3):303-5 Pediatr. Pulmonol.en_GB
dc.identifier.issn1099-0496-
dc.identifier.pmid22573417-
dc.identifier.doi10.1002/ppul.22583-
dc.identifier.urihttp://hdl.handle.net/10147/302410-
dc.description.abstractIdiopathic pulmonary hemosiderosis (IPH), a subtype of diffuse alveolar hemorrhage is a rare condition, first described by Virchow in 1864. Historically, it manifests in children in the first decade of life with the combination of hemoptysis, iron deficiency anemia, and alveolar infiltrates on chest radiograph. More recently, diffuse alveolar hemorrhage has been classified by the absence or presence of pulmonary capillaritis (PC), the latter carrying a potential for a poorer outcome. While systemic corticosteroids remain the first line treatment option, other immune modulators have been trailed including hydroxychloroquine, azathioprine, 6-mercaptopurine, and cyclophosphamide with varying results. Our case demonstrates for the first time, the successful use of intravenous cyclophosphamide in the management of chronic idiopathic PC.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Pediatric pulmonologyen_GB
dc.subject.meshChild-
dc.subject.meshCyclophosphamide-
dc.subject.meshHemosiderosis-
dc.subject.meshHumans-
dc.subject.meshImmunosuppressive Agents-
dc.subject.meshInfusions, Intravenous-
dc.subject.meshLung Diseases-
dc.subject.meshMale-
dc.titleSuccessful treatment of idiopathic pulmonary capillaritis with intravenous cyclophosphamide.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Respiratory Medicine, Children's University Hospital, Dublin, Ireland. fraflanagan@gmail.comen_GB
dc.identifier.journalPediatric pulmonologyen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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