Biomarkers of acute kidney injury in neonatal encephalopathy.

Hdl Handle:
http://hdl.handle.net/10147/300394
Title:
Biomarkers of acute kidney injury in neonatal encephalopathy.
Authors:
Sweetman, D U; Molloy, E J
Affiliation:
Department of Neonatology, National Maternity Hospital, Holles Street, Dublin, Ireland. dee.sweetman@gmail.com
Citation:
Biomarkers of acute kidney injury in neonatal encephalopathy. 2013, 172 (3):305-16 Eur. J. Pediatr.
Journal:
European journal of pediatrics
Issue Date:
Mar-2013
URI:
http://hdl.handle.net/10147/300394
DOI:
10.1007/s00431-012-1890-6
PubMed ID:
23138391
Abstract:
Acute kidney injury (AKI) is a common complication of neonatal encephalopathy (NE). The accurate diagnosis of neonatal AKI, irrespective of the cause, relies on suboptimal methods such as identification of rising serum creatinine, decreased urinary output and glomerular filtration rate. Studies of AKI biomarkers in adults and children have shown that biomarkers can improve the early diagnosis of AKI. Hypoxia-ischaemia is the proposed aetiological basis of AKI in both NE and cardiopulmonary bypass (CPB). However, there is a paucity of studies examining the role of AKI biomarkers specifically in NE. Urinary cystatin C (CysC), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18, kidney injury molecule-1, liver-type fatty acid-binding protein, serum CysC and serum NGAL all show good ability to predict early AKI in a heterogeneous critically ill neonatal population including infants post-CPB. Moreover, serum and urinary NGAL and urinary CysC are early predictors of AKI secondary to NE. These findings are promising and open up the possibility of biomarkers playing a significant role in the early diagnosis and treatment of NE-related AKI. There is an urgent need to explore the role of AKI biomarkers in infants with NE as establishing the diagnosis of AKI earlier may allow more timely intervention with potential for improving long-term outcome.
Item Type:
Article
Language:
en
Keywords:
NEONATE
MeSH:
Acute Kidney Injury; Biological Markers; Gestational Age; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn
ISSN:
1432-1076

Full metadata record

DC FieldValue Language
dc.contributor.authorSweetman, D Uen_GB
dc.contributor.authorMolloy, E Jen_GB
dc.date.accessioned2013-08-30T10:32:07Z-
dc.date.available2013-08-30T10:32:07Z-
dc.date.issued2013-03-
dc.identifier.citationBiomarkers of acute kidney injury in neonatal encephalopathy. 2013, 172 (3):305-16 Eur. J. Pediatr.en_GB
dc.identifier.issn1432-1076-
dc.identifier.pmid23138391-
dc.identifier.doi10.1007/s00431-012-1890-6-
dc.identifier.urihttp://hdl.handle.net/10147/300394-
dc.description.abstractAcute kidney injury (AKI) is a common complication of neonatal encephalopathy (NE). The accurate diagnosis of neonatal AKI, irrespective of the cause, relies on suboptimal methods such as identification of rising serum creatinine, decreased urinary output and glomerular filtration rate. Studies of AKI biomarkers in adults and children have shown that biomarkers can improve the early diagnosis of AKI. Hypoxia-ischaemia is the proposed aetiological basis of AKI in both NE and cardiopulmonary bypass (CPB). However, there is a paucity of studies examining the role of AKI biomarkers specifically in NE. Urinary cystatin C (CysC), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18, kidney injury molecule-1, liver-type fatty acid-binding protein, serum CysC and serum NGAL all show good ability to predict early AKI in a heterogeneous critically ill neonatal population including infants post-CPB. Moreover, serum and urinary NGAL and urinary CysC are early predictors of AKI secondary to NE. These findings are promising and open up the possibility of biomarkers playing a significant role in the early diagnosis and treatment of NE-related AKI. There is an urgent need to explore the role of AKI biomarkers in infants with NE as establishing the diagnosis of AKI earlier may allow more timely intervention with potential for improving long-term outcome.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to European journal of pediatricsen_GB
dc.subjectNEONATE-
dc.subject.meshAcute Kidney Injury-
dc.subject.meshBiological Markers-
dc.subject.meshGestational Age-
dc.subject.meshHumans-
dc.subject.meshHypoxia-Ischemia, Brain-
dc.subject.meshInfant, Newborn-
dc.titleBiomarkers of acute kidney injury in neonatal encephalopathy.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Neonatology, National Maternity Hospital, Holles Street, Dublin, Ireland. dee.sweetman@gmail.comen_GB
dc.identifier.journalEuropean journal of pediatricsen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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