RACK(1) to the future - a historical perspective

Hdl Handle:
http://hdl.handle.net/10147/299966
Title:
RACK(1) to the future - a historical perspective
Authors:
Ron, Dorit; Adams, David R; Baillie, George S; Long, Aideen; O’Connor, Rosemary; Kiely, Patrick A
Citation:
Cell Communication and Signaling. 2013 Aug 01;11(1):53
Issue Date:
1-Aug-2013
URI:
http://dx.doi.org/10.1186/1478-811X-11-53; http://hdl.handle.net/10147/299966
Abstract:
This perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.
Item Type:
Journal Article
Keywords:
GENETICS
Local subject classification:
CELL BIOLOGY

Full metadata record

DC FieldValue Language
dc.contributor.authorRon, Dorit-
dc.contributor.authorAdams, David R-
dc.contributor.authorBaillie, George S-
dc.contributor.authorLong, Aideen-
dc.contributor.authorO’Connor, Rosemary-
dc.contributor.authorKiely, Patrick A-
dc.date.accessioned2013-08-27T15:55:15Z-
dc.date.available2013-08-27T15:55:15Z-
dc.date.issued2013-08-01-
dc.identifier.citationCell Communication and Signaling. 2013 Aug 01;11(1):53-
dc.identifier.urihttp://dx.doi.org/10.1186/1478-811X-11-53-
dc.identifier.urihttp://hdl.handle.net/10147/299966-
dc.description.abstractThis perspective summarises the first and long overdue RACK1 meeting held at the University of Limerick, Ireland, May 2013, in which RACK1’s role in the immune system, the heart and the brain were discussed and its contribution to disease states such as cancer, cardiac hypertrophy and addiction were described. RACK1 is a scaffolding protein and a member of the WD repeat family of proteins. These proteins have a unique architectural assembly that facilitates protein anchoring and the stabilisation of protein activity. A large body of evidence is accumulating which is helping to define the versatile role of RACK1 in assembling and dismantling complex signaling pathways from the cell membrane to the nucleus in health and disease. In this commentary, we first provide a historical perspective on RACK1. We also address many of the pertinent and topical questions about this protein such as its role in transcription, epigenetics and translation, its cytoskeletal contribution and the merits of targeting RACK1 in disease.-
dc.subjectGENETICS-
dc.subject.otherCELL BIOLOGY-
dc.titleRACK(1) to the future - a historical perspective-
dc.typeJournal Article-
dc.language.rfc3066en-
dc.rights.holderDorit Ron et al.; licensee BioMed Central Ltd.-
dc.description.statusPeer Reviewed-
dc.date.updated2013-08-27T04:04:14Z-
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