Delayed villous maturation of the placenta: quantitative assessment in different cohorts.

Hdl Handle:
http://hdl.handle.net/10147/299524
Title:
Delayed villous maturation of the placenta: quantitative assessment in different cohorts.
Authors:
Treacy, Ann; Higgins, Mary; Kearney, John M; McAuliffe, Fionnuala; Mooney, Eoghan E
Affiliation:
Department of Pathology, National Maternity Hospital, Dublin, Ireland. anntreacy@mac.com
Citation:
Delayed villous maturation of the placenta: quantitative assessment in different cohorts., 16 (2):63-6 Pediatr. Dev. Pathol.
Journal:
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Issue Date:
2013
URI:
http://hdl.handle.net/10147/299524
DOI:
10.2350/12-06-1218-OA.1
PubMed ID:
23137099
Abstract:
Placental villous maturation is maximal in the 3rd trimester, with an abundance of terminal villi. Delayed villous maturation (DVM) of the placenta is associated with chromosomal abnormalities, gestational diabetes, and an adverse outcome. This study compares quantitative assessment of vasculo-syncytial membranes (VSM) in cases of liveborn infants, perinatal deaths, and controls. Cases were selected as follows: (1) liveborn infants with a qualitative diagnosis of DVM (n  =  15); (2) controls matched for gestational age whose placentas did not have DVM (n  =  15); (3) stillbirths (SB)/neonatal deaths (NND) showing DVM (n  =  13); and (4) SB from autopsies in which DVM was felt to be the cause of death (COD) (n  =  12). Vasculo-syncytial membranes were counted in 10 terminal villi in each of 10 consecutive high-power fields on 3 slides. Data analysis was carried out using SPSS. Liveborn cases with DVM showed statistically significantly less VSM than controls (mean 1.01 vs 2.42, P < 0.0001). The SB/NND group also showed significantly less VSM than the control group (mean 0.46 vs 2.42, P < 0.0001) and less than the liveborn DVM group (mean 0.46 vs 1.01, P  =  0.001). The COD group was significantly different from the control group (mean 0.42 vs 2.42, P < 0.0001) and the liveborn DVM group (mean 0.42 vs 1.01, P < 0.0001) but not significantly different from the SB/NND group. There is a quantitative reduction in VSM in cases of DVM compared to controls.
Item Type:
Article
Language:
en
Keywords:
PREGNANCY; OBSTETRICIAN
MeSH:
Chorionic Villi; Cohort Studies; Female; Fetal Diseases; Humans; Infant, Newborn; Male; Placenta Diseases; Pregnancy; Stillbirth
ISSN:
1093-5266

Full metadata record

DC FieldValue Language
dc.contributor.authorTreacy, Annen_GB
dc.contributor.authorHiggins, Maryen_GB
dc.contributor.authorKearney, John Men_GB
dc.contributor.authorMcAuliffe, Fionnualaen_GB
dc.contributor.authorMooney, Eoghan Een_GB
dc.date.accessioned2013-08-22T15:42:05Z-
dc.date.available2013-08-22T15:42:05Z-
dc.date.issued2013-
dc.identifier.citationDelayed villous maturation of the placenta: quantitative assessment in different cohorts., 16 (2):63-6 Pediatr. Dev. Pathol.en_GB
dc.identifier.issn1093-5266-
dc.identifier.pmid23137099-
dc.identifier.doi10.2350/12-06-1218-OA.1-
dc.identifier.urihttp://hdl.handle.net/10147/299524-
dc.description.abstractPlacental villous maturation is maximal in the 3rd trimester, with an abundance of terminal villi. Delayed villous maturation (DVM) of the placenta is associated with chromosomal abnormalities, gestational diabetes, and an adverse outcome. This study compares quantitative assessment of vasculo-syncytial membranes (VSM) in cases of liveborn infants, perinatal deaths, and controls. Cases were selected as follows: (1) liveborn infants with a qualitative diagnosis of DVM (n  =  15); (2) controls matched for gestational age whose placentas did not have DVM (n  =  15); (3) stillbirths (SB)/neonatal deaths (NND) showing DVM (n  =  13); and (4) SB from autopsies in which DVM was felt to be the cause of death (COD) (n  =  12). Vasculo-syncytial membranes were counted in 10 terminal villi in each of 10 consecutive high-power fields on 3 slides. Data analysis was carried out using SPSS. Liveborn cases with DVM showed statistically significantly less VSM than controls (mean 1.01 vs 2.42, P < 0.0001). The SB/NND group also showed significantly less VSM than the control group (mean 0.46 vs 2.42, P < 0.0001) and less than the liveborn DVM group (mean 0.46 vs 1.01, P  =  0.001). The COD group was significantly different from the control group (mean 0.42 vs 2.42, P < 0.0001) and the liveborn DVM group (mean 0.42 vs 1.01, P < 0.0001) but not significantly different from the SB/NND group. There is a quantitative reduction in VSM in cases of DVM compared to controls.en_GB
dc.language.isoenen
dc.rightsArchived with thanks to Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Societyen_GB
dc.subjectPREGNANCYen_GB
dc.subjectOBSTETRICIANen_GB
dc.subject.meshChorionic Villi-
dc.subject.meshCohort Studies-
dc.subject.meshFemale-
dc.subject.meshFetal Diseases-
dc.subject.meshHumans-
dc.subject.meshInfant, Newborn-
dc.subject.meshMale-
dc.subject.meshPlacenta Diseases-
dc.subject.meshPregnancy-
dc.subject.meshStillbirth-
dc.titleDelayed villous maturation of the placenta: quantitative assessment in different cohorts.en_GB
dc.typeArticleen
dc.contributor.departmentDepartment of Pathology, National Maternity Hospital, Dublin, Ireland. anntreacy@mac.comen_GB
dc.identifier.journalPediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Societyen_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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