Vitamin D Levels and myocardial function in preterm infants

Hdl Handle:
http://hdl.handle.net/10147/299243
Title:
Vitamin D Levels and myocardial function in preterm infants
Authors:
Armstrong, K; Onwunmeme, C; Franklin, O; Molloy, E
Publisher:
Archives of Disease in Childhood
Journal:
Archives of Disease in Childhood
Issue Date:
20-Aug-2013
URI:
http://hdl.handle.net/10147/299243
Additional Links:
Arch Dis Child 2012;97:A323 doi:10.1136/archdischild-2012-302724.1126
Abstract:
Bakground Low Vitamin D levels have been linked to cardiac failure in the adults and children. Tissue Doppler Imaging (TDI) is evolving as a superior measure of subtle changes in myocardial contractility in preterm infants. We aimed to correlate Vitamin D levels at birth with TDI measures of systolic and diastolic function. Methods Preterm infants < 32 weeks gestation were recruited. Vitamin D levels were measured at birth and echocardiography was carried out on Day 1. TDI myocardial velocities were recorded using a pulsed wave doppler sample from the lateral left/right ventricular wall & intraventricular septum. Peak systolic (S’), early diastolic (E’) and late diastolic (A’) velocities were recorded. Results Ten preterm infants with structurally normal hearts were recruited. Mean (SD) gestational age was 28 (1.7) weeks and birthweight 1.29 (0.3)kg. There was no significant increase in Right ventricular systolic (5.1cm/sec vs 4.8cm/sec)or diastolic myocardial velocity measures (5.2cm/sec vs 5.1cm/sec) or left myocardial velocity systolic (3.7cm/sec vs 3.9cm/sec) or diastolic (4.1cm/sec vs 4.0cm/sec) measures between those with severe Vitamin D deficiency (<30 nmol/L) and those with low normal levels of Vitamin D. Conclusion Neonates with severe Vitamin D deficiency have similar TDI measures of systolic and diastolic velocity to those with near normal levels. In our small cohort severe Vitamin D deficiency appears to cause no impairment in myocardial contractility.
Item Type:
Conference Poster
Language:
en
Keywords:
PREGNANCY

Full metadata record

DC FieldValue Language
dc.contributor.authorArmstrong, Ken_GB
dc.contributor.authorOnwunmeme, Cen_GB
dc.contributor.authorFranklin, Oen_GB
dc.contributor.authorMolloy, Een_GB
dc.date.accessioned2013-08-20T09:44:53Z-
dc.date.available2013-08-20T09:44:53Z-
dc.date.issued2013-08-20-
dc.identifier.urihttp://hdl.handle.net/10147/299243-
dc.description.abstractBakground Low Vitamin D levels have been linked to cardiac failure in the adults and children. Tissue Doppler Imaging (TDI) is evolving as a superior measure of subtle changes in myocardial contractility in preterm infants. We aimed to correlate Vitamin D levels at birth with TDI measures of systolic and diastolic function. Methods Preterm infants < 32 weeks gestation were recruited. Vitamin D levels were measured at birth and echocardiography was carried out on Day 1. TDI myocardial velocities were recorded using a pulsed wave doppler sample from the lateral left/right ventricular wall & intraventricular septum. Peak systolic (S’), early diastolic (E’) and late diastolic (A’) velocities were recorded. Results Ten preterm infants with structurally normal hearts were recruited. Mean (SD) gestational age was 28 (1.7) weeks and birthweight 1.29 (0.3)kg. There was no significant increase in Right ventricular systolic (5.1cm/sec vs 4.8cm/sec)or diastolic myocardial velocity measures (5.2cm/sec vs 5.1cm/sec) or left myocardial velocity systolic (3.7cm/sec vs 3.9cm/sec) or diastolic (4.1cm/sec vs 4.0cm/sec) measures between those with severe Vitamin D deficiency (<30 nmol/L) and those with low normal levels of Vitamin D. Conclusion Neonates with severe Vitamin D deficiency have similar TDI measures of systolic and diastolic velocity to those with near normal levels. In our small cohort severe Vitamin D deficiency appears to cause no impairment in myocardial contractility.en_GB
dc.language.isoenen
dc.publisherArchives of Disease in Childhooden_GB
dc.relation.urlArch Dis Child 2012;97:A323 doi:10.1136/archdischild-2012-302724.1126en_GB
dc.subjectPREGNANCYen_GB
dc.titleVitamin D Levels and myocardial function in preterm infantsen_GB
dc.typeConference Posteren
dc.identifier.journalArchives of Disease in Childhooden_GB
dc.description.fundingNo fundingen
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen
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