Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m).

Hdl Handle:
http://hdl.handle.net/10147/299231
Title:
Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m).
Authors:
McMorrow, R C N; Windsor, J S; Hart, N D; Richards, P; Rodway, G W; Ahuja, V Y; O'Dwyer, M J; Mythen, M G; Grocott, M P W
Affiliation:
UCL Centre for Altitude Space and Extreme Environment Medicine, UCL Institute of Child Health, University College London, London, UK. mcmorrow.roger@gmail.com
Citation:
Closed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). 2012, 67 (8):875-80 Anaesthesia
Publisher:
Anaesthesia
Journal:
Anaesthesia
Issue Date:
Aug-2012
URI:
http://hdl.handle.net/10147/299231
DOI:
10.1111/j.1365-2044.2012.07152.x
PubMed ID:
22519895
Abstract:
We present a randomised, controlled, crossover trial of the Caudwell Xtreme Everest (CXE) closed circuit breathing system vs an open circuit and ambient air control in six healthy, hypoxic volunteers at rest and exercise at Everest Base Camp, at 5300 m. Compared with control, arterial oxygen saturations were improved at rest with both circuits. There was no difference in the magnitude of this improvement as both circuits restored median (IQR [range]) saturation from 75%, (69.5-78.9 [68-80]%) to > 99.8% (p = 0.028). During exercise, the CXE closed circuit improved median (IQR [range]) saturation from a baseline of 70.8% (63.8-74.5 [57-76]%) to 98.8% (96.5-100 [95-100]%) vs the open circuit improvement to 87.5%, (84.1-88.6 [82-89]%; p = 0.028). These data demonstrate the inverse relationship between supply and demand with open circuits and suggest that ambulatory closed circuits may offer twin advantages of supplying higher inspired oxygen concentrations and/or economy of gas use for exercising hypoxic adults.
Item Type:
Article
Language:
en
MeSH:
Adult; Altitude; Cross-Over Studies; Exercise; Female; Heart Rate; Humans; Male; Middle Aged; Mountaineering; Oxygen; Respiration
ISSN:
1365-2044
Sponsors:
John Caudwell, BOC Medical, Eli Lilly, The London Clinic, Smiths Medical, Micropore Inc, Analytical Industries Inc, Deltex Medical, The Rolex Foundation, The Association of Anaesthetists fo Great Britain and Ireland, The UK Intensive Care Foundation, and the Sir Halley Stewart Trust. Some of the work was undertaken at University College London Hospital - University College London, Comprehensive Biomedical Research, which received a proportion of funding from the UK Department of Health's National Institute for Health Research Biomedical Research Centres funding scheme.

Full metadata record

DC FieldValue Language
dc.contributor.authorMcMorrow, R C Nen_GB
dc.contributor.authorWindsor, J Sen_GB
dc.contributor.authorHart, N Den_GB
dc.contributor.authorRichards, Pen_GB
dc.contributor.authorRodway, G Wen_GB
dc.contributor.authorAhuja, V Yen_GB
dc.contributor.authorO'Dwyer, M Jen_GB
dc.contributor.authorMythen, M Gen_GB
dc.contributor.authorGrocott, M P Wen_GB
dc.date.accessioned2013-08-20T09:30:41Z-
dc.date.available2013-08-20T09:30:41Z-
dc.date.issued2012-08-
dc.identifier.citationClosed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m). 2012, 67 (8):875-80 Anaesthesiaen_GB
dc.identifier.issn1365-2044-
dc.identifier.pmid22519895-
dc.identifier.doi10.1111/j.1365-2044.2012.07152.x-
dc.identifier.urihttp://hdl.handle.net/10147/299231-
dc.description.abstractWe present a randomised, controlled, crossover trial of the Caudwell Xtreme Everest (CXE) closed circuit breathing system vs an open circuit and ambient air control in six healthy, hypoxic volunteers at rest and exercise at Everest Base Camp, at 5300 m. Compared with control, arterial oxygen saturations were improved at rest with both circuits. There was no difference in the magnitude of this improvement as both circuits restored median (IQR [range]) saturation from 75%, (69.5-78.9 [68-80]%) to > 99.8% (p = 0.028). During exercise, the CXE closed circuit improved median (IQR [range]) saturation from a baseline of 70.8% (63.8-74.5 [57-76]%) to 98.8% (96.5-100 [95-100]%) vs the open circuit improvement to 87.5%, (84.1-88.6 [82-89]%; p = 0.028). These data demonstrate the inverse relationship between supply and demand with open circuits and suggest that ambulatory closed circuits may offer twin advantages of supplying higher inspired oxygen concentrations and/or economy of gas use for exercising hypoxic adults.en_GB
dc.description.sponsorshipJohn Caudwell, BOC Medical, Eli Lilly, The London Clinic, Smiths Medical, Micropore Inc, Analytical Industries Inc, Deltex Medical, The Rolex Foundation, The Association of Anaesthetists fo Great Britain and Ireland, The UK Intensive Care Foundation, and the Sir Halley Stewart Trust. Some of the work was undertaken at University College London Hospital - University College London, Comprehensive Biomedical Research, which received a proportion of funding from the UK Department of Health's National Institute for Health Research Biomedical Research Centres funding scheme.en_GB
dc.language.isoenen
dc.publisherAnaesthesiaen_GB
dc.rightsArchived with thanks to Anaesthesiaen_GB
dc.subject.meshAdult-
dc.subject.meshAltitude-
dc.subject.meshCross-Over Studies-
dc.subject.meshExercise-
dc.subject.meshFemale-
dc.subject.meshHeart Rate-
dc.subject.meshHumans-
dc.subject.meshMale-
dc.subject.meshMiddle Aged-
dc.subject.meshMountaineering-
dc.subject.meshOxygen-
dc.subject.meshRespiration-
dc.titleClosed and open breathing circuit function in healthy volunteers during exercise at Mount Everest base camp (5300 m).en_GB
dc.typeArticleen
dc.contributor.departmentUCL Centre for Altitude Space and Extreme Environment Medicine, UCL Institute of Child Health, University College London, London, UK. mcmorrow.roger@gmail.comen_GB
dc.identifier.journalAnaesthesiaen_GB
dc.description.fundingOtheren
dc.description.provinceLeinsteren
dc.description.peer-reviewpeer-reviewen

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